Solute Carrier Family 6 (Neurotransmitter Transporter, Noradrenalin), Member 2 (SLC6A2) ELISA Kits

Human Solute Carrier Family 6 (Neurotransmitter Transporter, Noradrenalin), Member 2 (SLC6A2) interaction partners

1. genetic association/pharmacogenetic studies in population in Switzerland: Data from controlled studies suggest that SNPs in SLC6A2 (rs1861647, rs2242446, rs36029) weakly moderate acute cardiovascular response to MDMA (methylenedioxymethamphetamine, "ecstasy") and may play minor role in adverse cardiovascular events when MDMA is used recreationally.

2. Our study indicates that DNA methylation levels of nine CpG sites in NET gene promoter region are not associated with depression and hypertension.

3. case-control study by genotyping 7 SNPs of SLC6A2, SLC6A3 (show SLC6A3 ELISA Kits) and DRD2 (show DRD2 ELISA Kits) in 1034 schizophrenia patients and 1034 controls. No significant difference in the allelic or genotypic frequency was detected between cases and controls

4. T allele of the SNP rs7194256 in the 3'UTR (show UTS2R ELISA Kits) of the NET gene is more prevalent in diseases where NET impairment is evident, including essential hypertension, depression, panic disorder and postural orthostatic tachycardia syndrome; mechanism involved may include the creation of a binding site for the miRNA miR (show MLXIP ELISA Kits)-19-3p, which is, at least in part, regulated by circulating norepinephrine concentrations

5. Polymorphisms of COMT (show COMT ELISA Kits) (c.649G>A), MAO-A (show MAOA ELISA Kits) (c.1460C>T), NET (c.1287G>A) Genes and the Level of Catecholamines, Serotonin in Patients with Parkinson's Disease

6. NET undergoes extensive constitutive internalization and internalized NET mainly is sorted to Rab11-positive recycling endosomes.

7. In Major Depressive Disorder patients there seems to be a relationship between the volume of the dorsolateral prefrontal cortex and polymorphism of the SLC6A2 G1287A gene.

8. This corticotropin releasing factor (show CRH ELISA Kits)-induced regulation on norepinephrine transporter expression and function may play a role in development of stress-related depression and anxiety

9. a NET 182C and 5-HTTLPR (show SLC6A4 ELISA Kits) polymorphism interaction is associated with susceptibility to treatment resistant depression and ECT treatment response in antidepressant resistant depression patients

10. NET gene variants are not involved in the etiology of recurrent major depressive disorder in Chinese Han population.

Mouse (Murine) Solute Carrier Family 6 (Neurotransmitter Transporter, Noradrenalin), Member 2 (SLC6A2) interaction partners

1. Differences in gene expression in the mouse frontal cortex with life-long norepinephrine transporter knock-out were studied using a whole-genome microarray approach

2. inhibition of p38 MAPK (show MAPK14 ELISA Kits) or the manipulation of NET-Thr (show TRH ELISA Kits)(30) motif/phosphorylation via a TAT (show TAT ELISA Kits) peptide strategy prevents cocaine-induced NET up-regulation, locomotor sensitization, and conditioned place preference

3. this is the first report which suggests the beneficial effect of modulation of TRPV1 (show TRPV1 ELISA Kits) receptors and NET in Chronic cerebral hypoperfusion vascular dementia

4. Norepinephrine transporter has a greater role in determining baseline analgesia and other analgesic effects in mice than serotonin transporter (show SLC6A4 ELISA Kits).

5. NET expression is essential for development and/or survival of some (5-HT (show DDC ELISA Kits)- and calretinin (show CALB2 ELISA Kits)-expressing), but not all (nNOS (show NOS1 ELISA Kits)-expressing), of these neurons.

6. propose that amplified norepinephrine transporter function in rictor (show RICTOR ELISA Kits) KO mice enhances accumulation of both norepinephrine and dopamine within the noradrenergic neuron

7. We identified that gene expression in neuronal cortical cells involves increased histone hyperacetylation on the Slc6a2 promoter, which is commensurate with the recruitment of SP1 and RNA Polymerase II and is inversely correlated with H3K9 trimethylation.

8. Data demonstrate that estrogen exerts significant modulatory effects on olfactory bulb function through modulation of tyrosine hydroxylase (show TH ELISA Kits), dopamine transporter and norepinephrine transporter expression.

9. this is the first report to suggest that the norepinephrine transporter gene is one of many possible genetic factors influencing ethanol sensitivity in ILS, ISS, and LXS RI mouse strains

10. The effects of DAT (show SLC6A3 ELISA Kits) KO in animal models of depression are larger than those produced by NET or SERT (show SLC6A4 ELISA Kits) KO, and unlikely to be simply the result of the confounding effects of locomotor hyperactivity.