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A time-dependent decrease in serum and tissue ADMA and increase in mRNA expression of DDAH-1 and PRMT-1 as well as higher rates of mRNA expression of CAT-1 and lower rates of CAT-2A and CAT-2B were found after 8-week MCD diet.
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In the absence of CAT2, Myeloid-derived suppressor cells display diminished capacity for controlling T cell immunity in prostate inflammation and cancer models, where the loss of CAT2 results in enhanced antitumor activity.
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demonstration of how most nuclear-retained CTN-RNAs stabilize at the periphery of paraspeckles, how CTN-RNA regulates its protein-coding partner, and how the mCAT2 gene can maintain a stable expression
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cationic transporter CAT2 plays an important role in controlling inflammation and IL-17 activation in an injury model of colitis
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These results demonstrate that the availability of arginine, mediated by Slc7a2, controls critical aspects of macrophage activation and reveal a factor for susceptibility to Leishmania infection.
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CAT-2A and CAT-1 L-arginine transporters are increased in cardiomyocytes from Duchenne muscular dystrophy mice.
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CAT2 is an important regulator of the immune response during H. pylori infection.
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Uptake of L-Arg, and its metabolism by Arg1 to L-Orn and conversion to L-Pro by OAT is essential for colonic epithelial wound repair.
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Results identify CAT2 as a regulator of fibrotic responses in the lung.
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IL-10 attenuated the LPS-induced upregulation of CAT-2 mRNA in macrophage cells. Results suggest that transcriptional control of CAT-2 by IL-10 regulates iNOS activity.
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The cationic amino acid transporter 2B may regulate supply of L-arginine to iNOS.
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We conclude that BMM present mainly y(+)L activity and that, in response to GM-CSF, l-arginine transport augments through CAT2, thereby increasing the availability of this amino acid to the cell.
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Increased L-arginine transport mediated by both T helper cell (Th)1-type and Th2-type endogenous activators is strongly regulated by Slc7a2/CAT2 expression, which could limit the function of macrophages.
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SLC7A2 mediates the increase in arginine transport in mouse macrophages during activition but not during proliferation.
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These data suggest that CAT2 regulates anti-inflammatory processes in the lungs via regulation of dendritic cell activation and subsequent T cell responses.
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CAT-2 exerts control over airway smooth muscle force development through a spermine-dependent pathway that directly correlates with the expression level of PIP-5K-gamma in the lung.
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By controlling NOS2 and arginase activity, CAT2 functions as a potent regulator of immunity.
