Solute Carrier Family 7 (Cationic Amino Acid Transporter, Y+ System), Member 2 Proteins (SLC7A2)

Human Solute Carrier Family 7 (Cationic Amino Acid Transporter, Y+ System), Member 2 (SLC7A2) interaction partners

1. L-homoarginine is a substrate of the cationic amino acid transporters CAT1, CAT2A and CAT2B.

2. genetic association studies in population in Tennessee: Data suggest that an SNP in SLC7A2 (rs2720574) is associated with response to dietary calcium and magnesium in prevention of colorectal polyps and colorectal ademonas.

3. Identification of cysteine residues in human cationic amino acid transporter hCAT-2A that are targets for inhibition by N-ethylmaleimide.

4. CAT1, CAT2, and CAT3 localized in adult brains but with uneven distribution.

5. A chimera carrying the functional domain of the orphan protein SLC7A14 in the backbone of SLC7A2 mediates trans-stimulated arginine transport.

6. Addition of spermine or knockdown of CAT2 inhibited L-Arg uptake, NO production, and iNOS protein levels, whereas knockdown of ODC had the opposite effect. CAT2 and ODC were increased in mouse and human H pylori gastritis tissues.

7. Activation of PKCalpha by phorbol esters or thymeleatoxin causes a transient increase of arginine transport through system y(+), referable to the induction of SLC7A2 mRNAs and to the increased expression of CAT2 transporters.

8. analysis of the genomic organization

9. Keratinocytes express cationic amino acid transporters 1 and 2. Cationic amino acid transporter mediated L-arginine essential for inducible nitric oxide synthase and arginase enzyme, which modulate proliferation and differentiation of epidermal cells.

10. Insulin increased L-arginine transport and the mRNA levels for hCAT-1 and hCAT-2B

11. distribution of human cationic amino acid transporters 1 (hCAT1) and 2 (hCAT2) in healthy skin and compared it to psoriatic skin lesions by means of immunohistochemistry

Mouse (Murine) Solute Carrier Family 7 (Cationic Amino Acid Transporter, Y+ System), Member 2 (SLC7A2) interaction partners

1. data reveal that SLC7A2 has a significant role in the protection from colitis-associated carcinogenesis (CAC) in the setting of chronic colitis, and suggest that the decreased SLC7A2 in inflammatory bowel disease (IBD) may contribute to CAC risk.

2. A time-dependent decrease in serum and tissue ADMA and increase in mRNA expression of DDAH-1 and PRMT-1 as well as higher rates of mRNA expression of CAT-1 and lower rates of CAT-2A and CAT-2B were found after 8-week MCD diet.

3. In the absence of CAT2, Myeloid-derived suppressor cells display diminished capacity for controlling T cell immunity in prostate inflammation and cancer models, where the loss of CAT2 results in enhanced antitumor activity.

4. demonstration of how most nuclear-retained CTN-RNAs stabilize at the periphery of paraspeckles, how CTN-RNA regulates its protein-coding partner, and how the mCAT2 gene can maintain a stable expression

5. cationic transporter CAT2 plays an important role in controlling inflammation and IL-17 activation in an injury model of colitis

6. These results demonstrate that the availability of arginine, mediated by Slc7a2, controls critical aspects of macrophage activation and reveal a factor for susceptibility to Leishmania infection.

7. CAT-2A and CAT-1 L-arginine transporters are increased in cardiomyocytes from Duchenne muscular dystrophy mice.

8. CAT2 is an important regulator of the immune response during H. pylori infection.

9. Uptake of L-Arg, and its metabolism by Arg1 to L-Orn and conversion to L-Pro by OAT is essential for colonic epithelial wound repair.

10. Results identify CAT2 as a regulator of fibrotic responses in the lung.

11. IL-10 attenuated the LPS-induced upregulation of CAT-2 mRNA in macrophage cells. Results suggest that transcriptional control of CAT-2 by IL-10 regulates iNOS activity.

12. The cationic amino acid transporter 2B may regulate supply of L-arginine to iNOS.

13. We conclude that BMM present mainly y(+)L activity and that, in response to GM-CSF, l-arginine transport augments through CAT2, thereby increasing the availability of this amino acid to the cell.

14. Increased L-arginine transport mediated by both T helper cell (Th)1-type and Th2-type endogenous activators is strongly regulated by Slc7a2/CAT2 expression, which could limit the function of macrophages.

15. SLC7A2 mediates the increase in arginine transport in mouse macrophages during activition but not during proliferation.

16. These data suggest that CAT2 regulates anti-inflammatory processes in the lungs via regulation of dendritic cell activation and subsequent T cell responses.

17. CAT-2 exerts control over airway smooth muscle force development through a spermine-dependent pathway that directly correlates with the expression level of PIP-5K-gamma in the lung.

18. By controlling NOS2 and arginase activity, CAT2 functions as a potent regulator of immunity.