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The protein encoded by SLC7A2 is a cationic amino acid transporter and a member of the APC (amino acid-polyamine-organocation) family of transporters. Additionally we are shipping SLC7A2 Antibodies (24) and SLC7A2 Kits (1) and many more products for this protein.
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genetic association studies in population in Tennessee: Data suggest that an SNP in SLC7A2 (rs2720574) is associated with response to dietary calcium and magnesium in prevention of colorectal polyps and colorectal ademonas.
Identification of cysteine residues in human cationic amino acid transporter hCAT-2A that are targets for inhibition by N-ethylmaleimide.
CAT1, CAT2, and CAT3 localized in adult brains but with uneven distribution.
A chimera carrying the functional domain of the orphan protein SLC7A14 in the backbone of SLC7A2 mediates trans-stimulated arginine transport.
Addition of spermine or knockdown of CAT2 inhibited L-Arg uptake, NO production, and iNOS (show NOS2 Proteins) protein levels, whereas knockdown of ODC (show ODC1 Proteins) had the opposite effect. CAT2 and ODC (show ODC1 Proteins) were increased in mouse and human H pylori gastritis tissues.
Activation of PKCalpha (show PKCa Proteins) by phorbol esters or thymeleatoxin causes a transient increase of arginine transport through system y(+), referable to the induction of SLC7A2 mRNAs and to the increased expression of CAT2 transporters.
Keratinocytes express cationic amino acid transporters 1 and 2. Cationic amino acid transporter mediated L-arginine essential for inducible nitric oxide synthase and arginase enzyme, which modulate proliferation and differentiation of epidermal cells.
Insulin (show INS Proteins) increased L-arginine (show GATM Proteins) transport and the mRNA levels for hCAT-1 (show SLC7A1 Proteins) and hCAT-2B
distribution of human cationic amino acid transporters 1 (hCAT1 (show SLC7A1 Proteins)) and 2 (hCAT2) in healthy skin and compared it to psoriatic skin lesions by means of immunohistochemistry
A time-dependent decrease in serum and tissue ADMA and increase in mRNA expression of DDAH-1 and PRMT-1 as well as higher rates of mRNA expression of CAT-1 and lower rates of CAT-2A and CAT-2B were found after 8-week MCD diet.
In the absence of CAT2, Myeloid-derived suppressor cells display diminished capacity for controlling T cell immunity in prostate inflammation and cancer models, where the loss of CAT2 results in enhanced antitumor activity.
demonstration of how most nuclear-retained CTN (show CALCA Proteins)-RNAs stabilize at the periphery of paraspeckles, how CTN (show CALCA Proteins)-RNA regulates its protein-coding partner, and how the mCAT2 gene can maintain a stable expression
cationic transporter CAT2 plays an important role in controlling inflammation and IL-17 (show IL17A Proteins) activation in an injury model of colitis
These results demonstrate that the availability of arginine, mediated by Slc7a2, controls critical aspects of macrophage activation and reveal a factor for susceptibility to Leishmania infection.
CAT-2A and CAT-1 (show SLC7A1 Proteins) L-arginine (show GATM Proteins) transporters are increased in cardiomyocytes from Duchenne muscular dystrophy (show DMD Proteins) mice.
CAT2 is an important regulator of the immune response during H. pylori infection.
Uptake of L-Arg, and its metabolism by Arg1 (show ARG1 Proteins) to L-Orn and conversion to L-Pro by OAT (show OAT Proteins) is essential for colonic epithelial wound repair.
Results identify CAT2 as a regulator of fibrotic responses in the lung.
IL-10 (show IL10 Proteins) attenuated the LPS (show TLR4 Proteins)-induced upregulation of CAT-2 mRNA in macrophage cells. Results suggest that transcriptional control of CAT-2 by IL-10 (show IL10 Proteins) regulates iNOS (show NOS2 Proteins) activity.
The protein encoded by this gene is a cationic amino acid transporter and a member of the APC (amino acid-polyamine-organocation) family of transporters. The encoded membrane protein is responsible for the cellular uptake of arginine, lysine and ornithine. Three transcript variants encoding different isoforms have been found for this gene.
solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
, Solute carrier family 7 member 2
, Low affinity cationic amino acid transporter 2
, low affinity cationic amino acid transporter 2
, solute carrier family 7 member 2
, T-cell early activation protein
, amino acid transporter, cationic 2 (low affinity)
, cationic amino acid transporter 2A
, cationic amino acid transporter 2B
, cationic transporter CAT2
, cationic amino acid transporter-2A
, solute carrier family 7, member 2
, cationic amino acid transporter-2