Solute Carrier Family 7 (Cationic Amino Acid Transporter, Y+ System), Member 2 Proteins (SLC7A2)

The protein encoded by SLC7A2 is a cationic amino acid transporter and a member of the APC (amino acid-polyamine-organocation) family of transporters. Additionally we are shipping SLC7A2 Antibodies (24) and and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SLC7A2 6542 P52569
SLC7A2 11988 P18581
Rat SLC7A2 SLC7A2 64554 B5D5N9
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Top SLC7A2 Proteins at antibodies-online.com

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 60 to 65 Days
$10,699.55
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Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 60 to 65 Days
$7,506.65
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Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 11 Days
$888.80
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SLC7A2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

More Proteins for Solute Carrier Family 7 (Cationic Amino Acid Transporter, Y+ System), Member 2 (SLC7A2) Interaction Partners

Human Solute Carrier Family 7 (Cationic Amino Acid Transporter, Y+ System), Member 2 (SLC7A2) interaction partners

  1. L-homoarginine is a substrate of the cationic amino acid transporters CAT1, CAT2A and CAT2B.

  2. genetic association studies in population in Tennessee: Data suggest that an SNP in SLC7A2 (rs2720574) is associated with response to dietary calcium and magnesium in prevention of colorectal polyps and colorectal ademonas.

  3. Identification of cysteine residues in human cationic amino acid transporter hCAT-2A that are targets for inhibition by N-ethylmaleimide.

  4. CAT1, CAT2, and CAT3 localized in adult brains but with uneven distribution.

  5. A chimera carrying the functional domain of the orphan protein SLC7A14 in the backbone of SLC7A2 mediates trans-stimulated arginine transport.

  6. Addition of spermine or knockdown of CAT2 inhibited L-Arg uptake, NO production, and iNOS protein levels, whereas knockdown of ODC had the opposite effect. CAT2 and ODC were increased in mouse and human H pylori gastritis tissues.

  7. Activation of PKCalpha by phorbol esters or thymeleatoxin causes a transient increase of arginine transport through system y(+), referable to the induction of SLC7A2 mRNAs and to the increased expression of CAT2 transporters.

  8. analysis of the genomic organization

  9. Keratinocytes express cationic amino acid transporters 1 and 2. Cationic amino acid transporter mediated L-arginine essential for inducible nitric oxide synthase and arginase enzyme, which modulate proliferation and differentiation of epidermal cells.

  10. Insulin increased L-arginine transport and the mRNA levels for hCAT-1 and hCAT-2B

  11. distribution of human cationic amino acid transporters 1 (hCAT1) and 2 (hCAT2) in healthy skin and compared it to psoriatic skin lesions by means of immunohistochemistry

Mouse (Murine) Solute Carrier Family 7 (Cationic Amino Acid Transporter, Y+ System), Member 2 (SLC7A2) interaction partners

  1. data reveal that SLC7A2 has a significant role in the protection from colitis-associated carcinogenesis (CAC) in the setting of chronic colitis, and suggest that the decreased SLC7A2 in inflammatory bowel disease (IBD) may contribute to CAC risk.

  2. A time-dependent decrease in serum and tissue ADMA and increase in mRNA expression of DDAH-1 and PRMT-1 as well as higher rates of mRNA expression of CAT-1 and lower rates of CAT-2A and CAT-2B were found after 8-week MCD diet.

  3. In the absence of CAT2, Myeloid-derived suppressor cells display diminished capacity for controlling T cell immunity in prostate inflammation and cancer models, where the loss of CAT2 results in enhanced antitumor activity.

  4. demonstration of how most nuclear-retained CTN-RNAs stabilize at the periphery of paraspeckles, how CTN-RNA regulates its protein-coding partner, and how the mCAT2 gene can maintain a stable expression

  5. cationic transporter CAT2 plays an important role in controlling inflammation and IL-17 activation in an injury model of colitis

  6. These results demonstrate that the availability of arginine, mediated by Slc7a2, controls critical aspects of macrophage activation and reveal a factor for susceptibility to Leishmania infection.

  7. CAT-2A and CAT-1 L-arginine transporters are increased in cardiomyocytes from Duchenne muscular dystrophy mice.

  8. CAT2 is an important regulator of the immune response during H. pylori infection.

  9. Uptake of L-Arg, and its metabolism by Arg1 to L-Orn and conversion to L-Pro by OAT is essential for colonic epithelial wound repair.

  10. Results identify CAT2 as a regulator of fibrotic responses in the lung.

  11. IL-10 attenuated the LPS-induced upregulation of CAT-2 mRNA in macrophage cells. Results suggest that transcriptional control of CAT-2 by IL-10 regulates iNOS activity.

  12. The cationic amino acid transporter 2B may regulate supply of L-arginine to iNOS.

  13. We conclude that BMM present mainly y(+)L activity and that, in response to GM-CSF, l-arginine transport augments through CAT2, thereby increasing the availability of this amino acid to the cell.

  14. Increased L-arginine transport mediated by both T helper cell (Th)1-type and Th2-type endogenous activators is strongly regulated by Slc7a2/CAT2 expression, which could limit the function of macrophages.

  15. SLC7A2 mediates the increase in arginine transport in mouse macrophages during activition but not during proliferation.

  16. These data suggest that CAT2 regulates anti-inflammatory processes in the lungs via regulation of dendritic cell activation and subsequent T cell responses.

  17. CAT-2 exerts control over airway smooth muscle force development through a spermine-dependent pathway that directly correlates with the expression level of PIP-5K-gamma in the lung.

  18. By controlling NOS2 and arginase activity, CAT2 functions as a potent regulator of immunity.

SLC7A2 Protein Profile

Protein Summary

The protein encoded by this gene is a cationic amino acid transporter and a member of the APC (amino acid-polyamine-organocation) family of transporters. The encoded membrane protein is responsible for the cellular uptake of arginine, lysine and ornithine. Three transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with SLC7A2

  • solute carrier family 7 (cationic amino acid transporter, y+ system), member 2, gene 2 L homeolog (slc7a2.2.L)
  • solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 (slc7a2)
  • solute carrier family 7 member 2 (SLC7A2)
  • solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 (Slc7a2)
  • solute carrier family 7 member 2 (Slc7a2)
  • AI158848 protein
  • Atrc2 protein
  • CAT-2 protein
  • Cat2 protein
  • Cat2a protein
  • Cat2b protein
  • cCAT-2 protein
  • HCAT2 protein
  • MGC83504 protein
  • RCAT2 protein
  • slc7a2 protein
  • Tea protein
  • zgc:103686 protein

Protein level used designations for SLC7A2

solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 , Solute carrier family 7 member 2 , Low affinity cationic amino acid transporter 2 , CAT-2 , CAT2 , low affinity cationic amino acid transporter 2 , solute carrier family 7 member 2 , 20.5 , T-cell early activation protein , amino acid transporter, cationic 2 (low affinity) , cationic amino acid transporter 2A , cationic amino acid transporter 2B , cationic transporter CAT2 , cationic amino acid transporter-2A , solute carrier family 7, member 2 , cationic amino acid transporter-2

GENE ID SPECIES
447047 Xenopus laevis
494041 Danio rerio
6542 Homo sapiens
11988 Mus musculus
64554 Rattus norvegicus
422730 Gallus gallus
100037298 Sus scrofa
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