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SNX1 encodes a member of the sorting nexin family.
Showing 10 out of 107 products:
Human Polyclonal SNX1 Primary Antibody for ICC, IF - ABIN151750
Kurten, Eddington, Chowdhury, Smith, Davidson, Shank: Self-assembly and binding of a sorting nexin to sorting endosomes. in Journal of cell science 2001
Show all 2 Pubmed References
Human Polyclonal SNX1 Primary Antibody for ELISA, ICC - ABIN4354976
Mari, Bujny, Zeuschner, Geerts, Griffith, Petersen, Cullen, Klumperman, Geuze: SNX1 defines an early endosomal recycling exit for sortilin and mannose 6-phosphate receptors. in Traffic (Copenhagen, Denmark) 2008
Data suggest that GLP1R (show GLP1R Antibodies) signaling in pancreatic beta-cells leading to insulin (show INS Antibodies) secretion involves interactions of GLP1R (show GLP1R Antibodies) with HIP1 (show HIP1 Antibodies), SNX1, and SNX27 (show SNX27 Antibodies); HIP1 (show HIP1 Antibodies) appears to regulate coupling of cell surface GLP1R (show GLP1R Antibodies) activation with endocytosis; SNX1 and SNX27 (show SNX27 Antibodies) appear to control balance between GLP1R (show GLP1R Antibodies) plasma membrane recycling and lysosomal degradation.
SNX1 was down-regulated in CRC (show CALR Antibodies) and associated with poor prognosis. Our data also showed that SNX1 inhibited the proliferation of CRC (show CALR Antibodies) cells and increased the sensitivity to the most commonly used drugs for CRC (show CALR Antibodies).
miR (show MLXIP Antibodies)-95 functions as an oncogene (show RAB1A Antibodies) role in non-small cell lung cancer cells by directly targeting SNX1.
Results show that suppression of EGFR (show EGFR Antibodies) membrane recycling by SNX1 appears to be critical for the activation of EGFR (show EGFR Antibodies) /PI3K (show PIK3CA Antibodies)/AKT (show AKT1 Antibodies) signaling pathway in human lung cancer cells.
we suggest that SNX1 is involved in the negative regulation of ligand-induced EGFR (show EGFR Antibodies) phosphorylation and mediates EGFR (show EGFR Antibodies)/pEGFR trafficking out of early endosomes
SNX1 has a crucial role in D(5)R trafficking and SNX1 depletion results in D(5)R dysfunction and thus may represent a novel mechanism for the pathogenesis of essential hypertension
This study found that significant evidence of association with SNX1 (VEGAS p = 0.035) in patient with Alzheimer disease.
SNX4, but not SNX1 and SNX8, is associated with the Rab11-recycling endosomes and that a high frequency of SNX4-mediated tubule formation is observed as endosomes undergo Rab4-to-Rab11 transition.
Results demonstrate that miR (show MLXIP Antibodies)-95 increases proliferation by directly targeting SNX1, defining miR (show MLXIP Antibodies)-95 as a new oncogenic miRNA in CRC (show CALR Antibodies).
SNX1 and SNX2 interact with Kalirin-7. Overexpression of SNX1 or SNX2 and Kalirin-7 partially redistributes both SNXs to the plasma membrane, and results in RhoG-dependent lamellipodia formation.
SNX1 interacts with Arf6 (show ARF6 Antibodies) to mediate neurite formation which is regulated by EFA6A (show PSD Antibodies).
A RUN Domain from DENND5/Rab6IP1 (show DENND5A Antibodies) binds sorting Nexin 1 and is involved in the trafficking of vesicles at the level of Golgi.
show that mice lacking sorting nexin 1 or sorting nexin 2 (show SNX2 Antibodies) are viable and fertile, whereas embryos deficient in both proteins arrest at midgestation.
HkRP1 (show CCDC88A Antibodies) is involved in the process of tubulation of sorting nexin-1 positive membranes from early endosome subdomains
Data describe a functional interaction between Hbeta58, sorting nexin 1 (SNX1), and SNX2 (show SNX2 Antibodies) and strongly suggest that SNX2 (show SNX2 Antibodies) plays a more critical role than SNX1 in retromer activity during embryonic development.
overexpression of FAB1A-GFP reassembles SNX2b-mRFP on the endosomal membrane despite the absence of SNX1.
A loss of FAB1 function causes the release of late endosomal proteins, Ara7, and SNX1 from the endosome membrane, indicating that FAB1, or its product PtdIns(3,5)P2, mediates the maturation process of the late endosomes.
High temperature selectively promotes the retrieval of PIN2 (show TERF1 Antibodies) from late endosomes and sorts them to the plasma membrane through an endosomal trafficking pathway dependent on SORTING NEXIN1.
Our results reveal a role of SNX1 for the correct trafficking of IRT1 (show PARP3 Antibodies) and, thus, for modulating the activity of the iron uptake machinery
SNX1 phosphorylation is required for Arabidopsis seedling growth.
the microtubule-associated protein (show FAM82A2 Antibodies) CLASP (show CLASRP Antibodies) interacts with the retromer component sorting nexin 1 (SNX1) to mediate an association between endosomes and microtubules.
A combination of immunoelectron and fluorescence microscopy show that sorting nexin 1 (SNX1)localize to the trans-Golgi network (TGN (show TG Antibodies)), which is considered to represent the early endosome of plants.
Arabidopsis thaliana SORTING NEXIN 1 (AtSNX1) is involved in the auxin pathway and that PIN2 (show TERF1 Antibodies), but not PIN1 or AUX1, is transported through AtSNX1-containing endosomes [AtSNX1]
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This endosomal protein regulates the cell-surface expression of epidermal growth factor receptor. This protein also has a role in sorting protease-activated receptor-1 from early endosomes to lysosomes. This protein may form oligomeric complexes with family members. This gene results in three transcript variants encoding distinct isoforms.
sorting nexin 1
, nexin 1
, sorting nexin-1
, Sorting nexin-1
, sorting nexin 1A