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SNX9 encodes a member of the sorting nexin family.
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Human Polyclonal SNX9 Primary Antibody for ICC, IF - ABIN251269
Soulet, Yarar, Leonard, Schmid: SNX9 regulates dynamin assembly and is required for efficient clathrin-mediated endocytosis. in Molecular biology of the cell 2005
Show all 3 Pubmed References
Sorting nexin 9 (Snx9) can be implicated as a specific adaptor that replaces toca-1 (show FNBP1L Antibodies) to mobilize neural Wiskott-Aldrich syndrome protein and the Arp2 (show AICDA Antibodies)/3 complex.
The diversified changes associated with SNX9 expression in cancer highlight its importance as a central regulator of cancer cell behavior.
reduced levels of SNX9 were observed in blood samples from colorectal cancer patients, emphasizing the feasibility of its use as a diagnostic and prognostic biomarker sensing the host's immune status and inflammatory stage.
this study shows that SNX9 uses a unique mechanism to induce the tubulation of the plasma membrane which mediates proper membrane deformation during clathrin-mediated endocytosis.
SNX9 and CHC (show CLTC Antibodies) function in the same molecular pathway for chromosome alignment and segregation, which is dependent on their direct association.
The sorting nexin 9 (SNX9) subfamily members - SNX9, SNX18 (show SNX18 Antibodies) and SNX33 - are required for progression and completion of mitosis.
study identifies critical amino acids within the BAR domains of SNX9 and SNX33 as determinants for the specificity of BAR domain-mediated interactions and suggests that SNX9 and SNX33 have distinct molecular functions.
Findings suggest that EspF promotes EPEC invasion of intestinal epithelial cells by harnessing the membrane-deforming activity of SNX9.
The interaction with SNX9 is mediated by the proline-rich domain (PRD (show PRD Antibodies)) of Itch, a domain distinct from the conventional WW recognition domain, and the SH3 domain (show ITSN1 Antibodies) of SNX9.
SNX9 binding to aldolase (show ALD Antibodies) is structurally precluded by the binding of substrate to the active site.
The Cdc42 (show CDC42 Antibodies) target ACK2 interacts with sorting nexin 9 (SH3PX1) to regulate epidermal growth factor receptor (show EGFR Antibodies) degradation
Snx9-deficient mice do not show defects in development as well as auditory function, suggesting that SNX9 is not essential for mice development and hearing
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members, but does contain a SH3 domain near its N-terminus. This protein interacts with the cytoplasmic domains of the precursor but not the processed forms of a disintegrin and metalloprotease domain 9 and 15. This protein binds the beta-appendage domain of adaptor protein 2 and may function to assist adaptor protein 2 in its role at the plasma membrane. This protein interacts with activated Cdc42-associated kinase-2 to regulate the degradation of epidermal growth factor receptor protein.
sorting nexin 9
, sorting nexin-9-like
, SH3 and PX domain-containing protein 1
, SH3 and PX domain-containing protein 3A
, Wiskott-Aldrich syndrome protein (WASP) interactor protein
, sorting nexin-9