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may have a role in spermatogenesis [RGD, Feb 2006]..
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Identified a telomere localization domain on Speedy A covering the distal N terminus and the Cdk2-binding Ringo domain, and this domain is essential for the localization of Speedy A to telomeres.
RingoA is an important activator of Cdk2 (show CDK2 ELISA Kits) at meiotic telomeres.
the Spy1/RINGO family of proteins may play an essential role in regulating both normal and abnormal growth processes in the breast
Authors demonstrate that mammalian Spy1-mediated ERK (show EPHB2 ELISA Kits) activation increases ligand-independent phosphorylation and activation of estrogen receptor alpha (show ESR1 ELISA Kits), correlating with a decrease in tamoxifen sensitivity.
The authors find that Spy1 confers structural changes to Cdk2 (show CDK2 ELISA Kits) that obviate the requirement of Cdk (show CDK4 ELISA Kits) activation loop phosphorylation.
CRMP1 (show CRMP1 ELISA Kits) interacted with Spy1 which would disturb the association of CRMP1 (show CRMP1 ELISA Kits) with actin and was involved in the collapse of growth cones induced by Sema3A (show SEMA3A ELISA Kits) and regeneration after sciatic nerve crush.
Spy1 participates in the proliferation and apoptosis of epithelial ovarian cancer.
A novel Spy1-CLIPR-59 interplay was identified in glioblastoma resistance to TNF-alpha (show TNF ELISA Kits).
Cell adhesion to fibronectin down-regulates the expression of Spy1 and contributes to drug resistance in multiple myeloma cells.
we demonstrate that the atypical cyclin-like protein Spy1 plays a role in balancing the division properties of glioma cells with stemness properties
Our results suggest that Spy1 may be a possible prognostic indicator in NHLs, and it was correlated with phosphorylation of p27(Kip1 (show CDKN1B ELISA Kits)) on Thr187
Spy1 expression positively correlates with the malignancy of gliomas.
This study reports that Spy1 expression allows cells to evade checkpoints and apoptosis and suggest that Spy1 regulation of CDK2 (show CDK2 ELISA Kits) is important for the response to DNA damage.
may have a role in spermatogenesis
speedy homolog A (Xenopus laevis)
, speedy protein A
, speedy 1
, RINGO A
, mSpy/Ringo A
, protein expressed in male leptotene and zygotene spermatocytes 465
, rapid inducer of G2/M progression in oocytes A
, speedy A
, speedy A1
, speedy A2
, speedy homolog 1
, spermatogenesis related protein Gs4
, rapid inducer of G2/M progression in oocytes
, hSpy/Ringo A
, speedy homolog A