anti-Spen Homolog, Transcriptional Regulator (Drosophila) (SPEN) Antibodies

SPEN encodes a hormone inducible transcriptional repressor.

list all antibodies Gene Name GeneID UniProt
SPEN 23013 Q96T58
SPEN 56381 Q62504
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Top anti-SPEN Antibodies at

Showing 10 out of 17 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Human Goat Un-conjugated ELISA   100 μg 6 to 7 Days
Human Goat Un-conjugated ELISA   100 μg 11 to 14 Days
Human Rabbit Un-conjugated IF, IHC (p) Immunohistochemical staining of human rectum with SPEN polyclonal antibody  shows strong nuclear and slightly weaker cytoplasmic positivity in glandular cells. Immunofluorescent staining of human cell line U-251 MG with SPEN polyclonal antibody  at 1-4 ug/mL dilution shows positivity in nuclei but not nucleoli. 100 μL 11 to 12 Days
Human Goat APC ELISA   100 μL 16 Days
Human Goat Biotin ELISA   100 μL 16 Days
Human Goat FITC ELISA   100 μL 16 Days
Human Goat Alkaline Phosphatase (AP) ELISA   100 μL 16 Days
Human Goat PE ELISA   100 μL 16 Days
Human Rabbit Un-conjugated IP   100 μL 11 to 14 Days
Dog Rabbit Un-conjugated IP   100 μL 11 to 14 Days

Top referenced anti-SPEN Antibodies

  1. Human Polyclonal SPEN Primary Antibody for ELISA - ABIN547637 : Hiriart, Gruffat, Buisson, Mikaelian, Keppler, Meresse, Mercher, Bernard, Sergeant, Manet: Interaction of the Epstein-Barr virus mRNA export factor EB2 with human Spen proteins SHARP, OTT1, and a novel member of the family, OTT3, links Spen proteins with splicing regulation and mRNA export. in The Journal of biological chemistry 2005 (PubMed)

  2. Human Polyclonal SPEN Primary Antibody for IP - ABIN188790 : Korfanty, Stokowy, Chadalski, Toma-Jonik, Vydra, Widłak, Wojtaś, Gielniewski, Widlak: SPEN protein expression and interactions with chromatin in mouse testicular cells. in Reproduction (Cambridge, England) 2018 (PubMed)

  3. Human Polyclonal SPEN Primary Antibody for ICC, IF - ABIN4355627 : McHugh, Chen, Chow, Surka, Tran, McDonel, Pandya-Jones, Blanco, Burghard, Moradian, Sweredoski, Shishkin, Su, Lander, Hess, Plath, Guttman: The Xist lncRNA interacts directly with SHARP to silence transcription through HDAC3. in Nature 2015 (PubMed)

More Antibodies against SPEN Interaction Partners

Human Spen Homolog, Transcriptional Regulator (Drosophila) (SPEN) interaction partners

  1. our data demonstrate a role for SPEN in the regulation of primary cilia formation and cell migration in breast cancer cells, which may collectively explain why its expression is associated with time to metastasis in cohorts of patients with ERalpha-negative breast cancers.

  2. SPEN is a novel tumor-suppressor gene that may be clinically useful as a predictive biomarker of tamoxifen response in ERalpha-positive breast cancers.

  3. SPEN mutations were associated with diffuse large B-cell lymphoma with hepatitis C virus infection.

  4. Phosphorylation of the CK2 site on SMRT significantly increased affinity for SHARP.

  5. A structural study of the RNA binding properties of the RNA recognition motifs of SHARP.

  6. These results demonstrate a role for the inactivation of SHARP transcription in DM1 biology.

  7. MINT3 and MINT17 were informative for patient grouping to predict local recurrence in rectal cancer patients

  8. SHARP is a novel component of the HDAC corepressor complex, recruited by RBP-Jkappa to repress transcription of target genes in the absence of activated Notch.

  9. the conserved function of the SPOC domain of SHARP is to mediate interaction with SMRT/NCoR corepressors, and that Spen proteins play an essential role in the repression complex

  10. both the androgen receptor interacting domains of the coactivator SRC1 and of the corepressor SMRT compete for interaction with the androgen receptor N-terminus

  11. Pak1-SHARP interaction plays an essential role in enhancing the corepressor functions of SHARP, thereby modulating Notch signaling in human cancer cells.

  12. Msx2-interacting protein(MINT), human interacts with the UbcH8.

  13. SHARP gene and protein expression is elevated in human colon and ovarian endometrioid adenocarcinomas carrying gene defects leading to beta-catenin dysregulation.

  14. In functional assays, corepressor ETO, but not AML1/ETO, augments SHARP-mediated repression in an histone deacetylase-dependent manner.

Mouse (Murine) Spen Homolog, Transcriptional Regulator (Drosophila) (SPEN) interaction partners

  1. Spenito, a small Spen family member, counteracted Spen function in fat regulation. Finally, mouse Spen and Spenito transcript levels scaled directly with body fat in vivo, suggesting a conserved role in fat liberation and catabolism. This study demonstrates that Spen is a key regulator of energy balance and provides a molecular context to understand the metabolic defects that arise from Spen dysfunction.

  2. Spen is required for gene repression by Xist. Spen is not required for Xist RNA localization and the recruitment of chromatin modifications.

  3. Spen is required for Xist-mediated silencing.

  4. results suggest that Xist silences transcription by directly interacting with SHARP, recruiting SMRT, activating HDAC3, and deacetylating histones to exclude Pol II across the X chromosome

  5. MINT forms a high affinity complex with CSL; the domains of MINT and CSL that are necessary and sufficient for complex formation are delineated

  6. MINT plays an important role in tooth development, in particular, epithelial morphogenesis

  7. Notch1 in concert with Notch2 contributes to the morphogenesis of renal vesicles into S-shaped bodies in a RBP-J-dependent manner.

  8. Msx2-interacting nuclear target protein (MINT) competed with the intracellular region of Notch for binding to a DNA binding protein RBP-J and suppressed the transactivation activity of Notch signaling.

  9. Stra13, Dec and Sharp (Mint) bHLH repressors are dynamically regulated during mammary gland development and may function to regulate apoptosis

  10. MINT enhances Runx2 activation of multiprotein complexes assembled by the OCFRE

  11. MINT is involved in CRYBP1-mediated Col2a1 gene repression and may play a role in regulation of cartilage development

  12. Mint deficiency impairs differentiation of early T progenitors into double-negative cells, suggesting that Notch/RBP-J signaling negatively regulates DN1-DN2 transition

SPEN Antigen Profile

Protein Summary

This gene encodes a hormone inducible transcriptional repressor. Repression of transcription by this gene product can occur through interactions with other repressors, by the recruitment of proteins involved in histone deacetylation, or through sequestration of transcriptional activators. The product of this gene contains a carboxy-terminal domain that permits binding to other corepressor proteins. This domain also permits interaction with members of the NuRD complex, a nucleosome remodeling protein complex that contains deacetylase activity. In addition, this repressor contains several RNA recognition motifs that confer binding to a steroid receptor RNA coactivator\; this binding can modulate the activity of both liganded and nonliganded steroid receptors.

Gene names and symbols associated with SPEN

  • spen family transcriptional repressor (SPEN) antibody
  • SPEN homolog, transcriptional regulator (Drosophila) (Spen) antibody
  • HIAA0929 antibody
  • Mint antibody
  • mKIAA0929 antibody
  • RBM15C antibody
  • SHARP antibody

Protein level used designations for SPEN

Msx2 interacting nuclear target (MINT) homolog , SMART/HDAC1 associated repressor protein , SMART/HDAC1-associated repressor protein , msx2-interacting protein , nuclear receptor transcription cofactor , spen homolog, transcriptional regulator (Drosophila) , Msx2 interacting nuclear target protein

23013 Homo sapiens
419460 Gallus gallus
56381 Mus musculus
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