SPEN Products
(Spen Homolog, Transcriptional Regulator (SPEN))
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This gene encodes a hormone inducible transcriptional repressor. Repression of transcription by this gene product can occur through interactions with other repressors, by the recruitment of proteins involved in histone deacetylation, or through sequestration of transcriptional activators. The product of this gene contains a carboxy-terminal domain that permits binding to other corepressor proteins. This domain also permits interaction with members of the NuRD complex, a nucleosome remodeling protein complex that contains deacetylase activity. In addition, this repressor contains several RNA recognition motifs that confer binding to a steroid receptor RNA coactivator\; this binding can modulate the activity of both liganded and nonliganded steroid receptors. [provided by RefSeq, Jul 2008].
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Featured SPEN Categories
SPEN Antibodies
High quality antibodies with extensive validation data.
Recommended SPEN Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
IF, IHC (p)
Validations
- (2)
Cat. No.
ABIN5588624
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
ELISA
Validations
Cat. No.
ABIN185595
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
ELISA
Validations
Cat. No.
ABIN7096817
Quantity
100 μL
Datasheet
Datasheet
Latest Publications for our SPEN products
: "SPEN protein expression and interactions with chromatin in mouse testicular cells." in: Reproduction (Cambridge, England), Vol. 156, Issue 3, pp. 195-206, (2018) (PubMed).: "The Xist lncRNA interacts directly with SHARP to silence transcription through HDAC3." in: Nature, Vol. 521, Issue 7551, pp. 232-6, (2015) (PubMed).
: "Interaction of the Epstein-Barr virus mRNA export factor EB2 with human Spen proteins SHARP, OTT1, and a novel member of the family, OTT3, links Spen proteins with splicing regulation and mRNA export." in: The Journal of biological chemistry, Vol. 280, Issue 44, pp. 36935-45, (2005) (PubMed).
Synonyms and alternative names related to SPEN
spen family transcriptional repressor (SPEN), SPEN homolog, transcriptional regulator (Drosophila) (Spen), HIAA0929, MINT, Mint, mKIAA0929, RBM15C, SHARPProtein level used designations for SPEN
- Msx2 interacting nuclear target (MINT) homolog
- SMART/HDAC1 associated repressor protein
- SMART/HDAC1-associated repressor protein
- msx2-interacting protein
- nuclear receptor transcription cofactor
- spen homolog, transcriptional regulator (Drosophila)
- Msx2 interacting nuclear target protein
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