SPAM1 Proteins

Hyaluronidase degrades hyaluronic acid, a major structural proteoglycan found in extracellular matrices and basement membranes.

Data Quality
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Type
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    Protein
Antigen
  • 9
Reactivity
  • 7
  • 1
  • 1
Application
  • 5
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  • 2
  • 2
  • 2
Host
  • 4
  • 2
  • 2
  • 1
Binding Specificity
  • 1
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  • 1
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Conjugate
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Protein Type
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Format
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9 Products
Recombinant Protein, Insect Cells (Source), Purity >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot.
ReactivityHuman
Application Crys, ELISA, SDS, WB
Order details Cat. No. ABIN3081716
$9,371.15
Plus shipping costs $45.00 and $22.00 dry ice
Will be delivered in 60 Business Days
ReactivityHuman
Application AP, AA, ELISA, WB
Order details Cat. No. ABIN1321070
$338.33
2 μg
Plus shipping costs $45.00 and $22.00 dry ice
Delivery in 11 to 12 Business Days
ReactivityHuman
Application AP, AA, ELISA, WB
Order details Cat. No. ABIN1321072
$414.29
Plus shipping costs $45.00 and $22.00 dry ice
Delivery in 11 to 12 Business Days
Recombinant Protein, HEK-293 Cells (Source), Purity > 80 % as determined by SDS-PAGE and Coomassie blue staining
ReactivityHuman
Application AbP, Func, PI, STD
Order details Cat. No. ABIN2732494
$504.90
20 μg
Plus shipping costs $45.00 and $22.00 dry ice
Will be delivered in 11 Business Days
Recombinant Protein, HEK-293 Cells (Source), Purity ≥92 % by SDS-PAGE
ReactivityHuman
Application HPLC, SDS
Order details Cat. No. ABIN1888707
$1,025.00
Plus shipping costs $45.00
Delivery in 2 to 3 Business Days
Recombinant Protein, HEK-293 Cells (Source), Purity >92 % as determined by SDS-PAGE.
ReactivityHuman
Order details Cat. No. ABIN2181785
$1,375.00
Plus shipping costs $45.00
Delivery in 2 to 3 Business Days
Recombinant Protein, HEK-293 Cells (Source), Purity >92 % as determined by SDS-PAGE.
ReactivityHuman
Application WB
Order details Cat. No. ABIN2566867
$618.75
0.025 mg
Plus shipping costs $45.00
Delivery in 2 to 3 Business Days
ReactivityCynomolgus
Application ELISA
Order details Cat. No. ABIN1610527
$3,281.67
1 mg
Plus shipping costs $45.00
Delivery in 60 to 71 Business Days
ReactivityGuinea Pig
Application ELISA
Order details Cat. No. ABIN1461869
$3,285.33
1 mg
Plus shipping costs $45.00
Delivery in 60 to 71 Business Days
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SPAM1 Protein Profile

Protein Summary

Hyaluronidase degrades hyaluronic acid, a major structural proteoglycan found in extracellular matrices and basement membranes. Six members of the hyaluronidase family are clustered into two tightly linked groups on chromosome 3p21.3 and 7q31.3. This gene was previously referred to as HYAL1 and HYA1 and has since been assigned the official symbol SPAM1\; another family member on chromosome 3p21.3 has been assigned HYAL1. This gene encodes a GPI-anchored enzyme located on the human sperm surface and inner acrosomal membrane. This multifunctional protein is a hyaluronidase that enables sperm to penetrate through the hyaluronic acid-rich cumulus cell layer surrounding the oocyte, a receptor that plays a role in hyaluronic acid induced cell signaling, and a receptor that is involved in sperm-zona pellucida adhesion. Abnormal expression of this gene in tumors has implicated this protein in degradation of basement membranes leading to tumor invasion and metastasis. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with SPAM1

  • sperm adhesion molecule 1 (Spam1) antibody
  • sperm adhesion molecule 1 (SPAM1) antibody
  • sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) L homeolog (spam1.L) antibody
  • sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) (SPAM1) antibody
  • sperm adhesion molecule 1 (spam1) antibody
  • AV039194 antibody
  • HYA1 antibody
  • HYAL1 antibody
  • HYAL3 antibody
  • HYAL5 antibody
  • im:6902904 antibody
  • PH-20 antibody
  • PH20 antibody
  • SPAG15 antibody
  • Spam antibody
  • spam1 antibody
  • XEH1 antibody
  • zgc:158668 antibody

Protein level used designations for SPAM1

hyal-PH20 , hyaluronidase PH-20 , hyaluronoglucosaminidase PH-20 , sperm surface protein PH-20 , sperm protein PH-20 , PH-20 protein , sperm surface antigen 2B1 , hyaluronidase , sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) L homeolog , hyaluronidase, zona pellucida binding , sperm adhesion molecule 1

GENE ID SPECIES
20690 Mus musculus
100135624 Cavia porcellus
6677 Homo sapiens
100009391 Oryctolagus cuniculus
117037 Rattus norvegicus
398285 Xenopus laevis
353352 Bos taurus
791203 Danio rerio
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