SPAM1 Proteins
Hyaluronidase degrades hyaluronic acid, a major structural proteoglycan found in extracellular matrices and basement membranes.
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Sperm Adhesion Molecule 1 (PH-20 Hyaluronidase, Zona Pellucida Binding) (SPAM1) (AA 36-490) protein (His tag) Protein
Sperm Adhesion Molecule 1 (PH-20 Hyaluronidase, Zona Pellucida Binding) (SPAM1) (AA 1-509) protein (GST tag) Protein
Sperm Adhesion Molecule 1 (PH-20 Hyaluronidase, Zona Pellucida Binding) (SPAM1) (AA 346-445) protein (GST tag) Protein
Sperm Adhesion Molecule 1 (PH-20 Hyaluronidase, Zona Pellucida Binding) (SPAM1) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag) Protein
Sperm Adhesion Molecule 1 (PH-20 Hyaluronidase, Zona Pellucida Binding) (SPAM1) protein (His tag) Protein
Sperm Adhesion Molecule 1 (PH-20 Hyaluronidase, Zona Pellucida Binding) (SPAM1) (AA 36-482) protein (His tag) Protein
Sperm Adhesion Molecule 1 (PH-20 Hyaluronidase, Zona Pellucida Binding) (SPAM1) protein (Fc Tag) Protein
Sperm Adhesion Molecule 1 (PH-20 Hyaluronidase, Zona Pellucida Binding) (SPAM1) protein (His tag) Protein
Sperm Adhesion Molecule 1 (PH-20 Hyaluronidase, Zona Pellucida Binding) (SPAM1) (AA 36-491) protein (His tag) Protein
Sperm Adhesion Molecule 1 (PH-20 Hyaluronidase, Zona Pellucida Binding) (SPAM1) (AA 36-492) protein (His tag) Protein
SPAM1 Protein Profile
Protein Summary
Hyaluronidase degrades hyaluronic acid, a major structural proteoglycan found in extracellular matrices and basement membranes. Six members of the hyaluronidase family are clustered into two tightly linked groups on chromosome 3p21.3 and 7q31.3. This gene was previously referred to as HYAL1 and HYA1 and has since been assigned the official symbol SPAM1\; another family member on chromosome 3p21.3 has been assigned HYAL1. This gene encodes a GPI-anchored enzyme located on the human sperm surface and inner acrosomal membrane. This multifunctional protein is a hyaluronidase that enables sperm to penetrate through the hyaluronic acid-rich cumulus cell layer surrounding the oocyte, a receptor that plays a role in hyaluronic acid induced cell signaling, and a receptor that is involved in sperm-zona pellucida adhesion. Abnormal expression of this gene in tumors has implicated this protein in degradation of basement membranes leading to tumor invasion and metastasis. Multiple transcript variants encoding different isoforms have been found for this gene.
Gene names and symbols associated with SPAM1
- sperm adhesion molecule 1 (Spam1) antibody
- sperm adhesion molecule 1 (SPAM1) antibody
- sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) L homeolog (spam1.L) antibody
- sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) (SPAM1) antibody
- sperm adhesion molecule 1 (spam1) antibody
- AV039194 antibody
- HYA1 antibody
- HYAL1 antibody
- HYAL3 antibody
- HYAL5 antibody
- im:6902904 antibody
- PH-20 antibody
- PH20 antibody
- SPAG15 antibody
- Spam antibody
- spam1 antibody
- XEH1 antibody
- zgc:158668 antibody
Protein level used designations for SPAM1
hyal-PH20 , hyaluronidase PH-20 , hyaluronoglucosaminidase PH-20 , sperm surface protein PH-20 , sperm protein PH-20 , PH-20 protein , sperm surface antigen 2B1 , hyaluronidase , sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) L homeolog , hyaluronidase, zona pellucida binding , sperm adhesion molecule 1
| GENE ID | SPECIES |
|---|---|
| 20690 | Mus musculus |
| 100135624 | Cavia porcellus |
| 6677 | Homo sapiens |
| 100009391 | Oryctolagus cuniculus |
| 117037 | Rattus norvegicus |
| 398285 | Xenopus laevis |
| 353352 | Bos taurus |
| 791203 | Danio rerio |
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