Sperm Associated Antigen 6 Proteins
The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization.
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Sperm Associated Antigen 6 (SPAG6) (AA 1-509) protein (His tag) Protein
Sperm Associated Antigen 6 (SPAG6) (AA 1-507) protein (His tag) Protein
Sperm Associated Antigen 6 (SPAG6) (AA 1-458) protein (GST tag) Protein
Sperm Associated Antigen 6 (SPAG6) (Transcript Variant 2) protein (Myc-DYKDDDDK Tag) Protein
Sperm Associated Antigen 6 (SPAG6) Protein Profile
Protein Summary
The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm antibodies from an infertile man. This protein localizes to the tail of permeabilized human sperm and contains eight contiguous armadillo repeats, a motif known to mediate protein-protein interactions. Studies in mice suggest that this protein is involved in sperm flagellar motility and maintenance of the structural integrity of mature sperm. Several transcript variants encoding different isoforms have been found for this gene.
Gene names and symbols associated with SPAG6
- sperm associated antigen 6 (SPAG6) antibody
- sperm associated antigen 6-like (Spag6l) antibody
- sperm associated antigen 6 (Spag6) antibody
- sperm associated antigen 6 (spag6) antibody
- sperm associated antigen 6 L homeolog (spag6.L) antibody
- DKFZp459D035 antibody
- PF16 antibody
- repro-sa-1 antibody
- RGD1310892 antibody
- SPAG6 antibody
- zgc:91805 antibody
Protein level used designations for SPAG6
axoneme central apparatus protein , protein PF16 homolog , sperm flagellar protein , sperm-associated antigen 6 , axoneme protein , sperm associated antigen 6
GENE ID | SPECIES |
---|---|
9576 | Homo sapiens |
50525 | Mus musculus |
360747 | Rattus norvegicus |
420505 | Gallus gallus |
431757 | Danio rerio |
450348 | Pan troglodytes |
477978 | Canis lupus familiaris |
539424 | Bos taurus |
548730 | Xenopus (Silurana) tropicalis |
734748 | Xenopus laevis |
100134839 | Meleagris gallopavo |
100174630 | Pongo abelii |
100286811 | Sus scrofa |
100724896 | Cavia porcellus |
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