Sphingomyelin Synthase 2 Proteins (SGMS2)

Sphingomyelin, a major component of cell and Golgi membranes, is made by the transfer of phosphocholine from phosphatidylcholine onto ceramide, with diacylglycerol as a side product. Additionally we are shipping Sphingomyelin Synthase 2 Antibodies (62) and Sphingomyelin Synthase 2 Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SGMS2 166929 Q8NHU3
SGMS2 74442 Q9D4B1
Rat SGMS2 SGMS2 310849 Q4JM44
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Top Sphingomyelin Synthase 2 Proteins at antibodies-online.com

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50 to 55 Days
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 50 to 55 Days
Human Cells Human Fc Tag 100 μg Log in to see 20 to 21 Days
Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days

SGMS2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

More Proteins for Sphingomyelin Synthase 2 (SGMS2) Interaction Partners

Human Sphingomyelin Synthase 2 (SGMS2) interaction partners

  1. SMS (show SMS Proteins) regulates the expression and function of drug transporters P-gp (show ABCB4 Proteins) and MRP2 (show ABCC2 Proteins).

  2. PPARdelta (show PPARD Proteins) activation may be a potential risk of atherosclerosis through enhancing activity of SMS2

  3. F-actin polymerization in the region of HIV-1 membrane fusion was more prominent in Sms2-expressing cells than Sms (show SMS Proteins)-deficient cells.

  4. SMS1 (show SGMS1 Proteins) and SMS2 are capable of regulating TGN (show TG Proteins)-mediated protein trafficking and secretion

  5. Data indicate that the increased sphingomyelin mass was due to a rapid and highly specific activation of sphingomyelin synthases SMS1 (show SGMS1 Proteins) and SMS2.

  6. direct morphological evidence for the pro-atherogenic capabilities of sphingomyelin synthase 2

  7. Data show that SMS2 acting as a bifunctional enzyme with both SM and CPE synthase activity.

  8. Data show that sphingomyelin synthases SMS1 (show SGMS1 Proteins) and SMS2 are co-expressed in a variety of cell types and function as the key Golgi- and plasma membrane-associated SM synthases in human cervical carcinoma HeLa cells, respectively.

  9. Results indicate that both synthase (SMS)1 (show SGMS1 Proteins) and 2 contribute to sphingomyelin (SM) de novo synthesis and control SM levels in the cells and on the cell membrane including plasma membrane.

  10. SMS2 is a key factor in control of sphingomyelin and diacylglycerol metabolism within the cell, and thus it influences apoptosis.

Mouse (Murine) Sphingomyelin Synthase 2 (SGMS2) interaction partners

  1. This study showed that MWM learning was deteriorated and associated with depression-like tendency in SMS2 KO mice.

  2. These results demonstrate that SMS2 deficiency inhibits DSS (show PMP22 Proteins)-induced colitis and subsequent colitis-associated colon cancer via inhibition of colon epithelial cell-mediated inflammation; therefore, inhibition of SMS2 may be a potential therapeutic target for human colitis and colorectal cancer.

  3. It was suggested that very long chain SM but not long chain SM were decreased in SMS2-deficient mice liver and plasma. And the exogenously added very long chain SM (d18:1/24:0) could activate macrophages directly, suggesting a novel role of plasma very long chain SM in modulating macrophage activation and resulting inflammation.

  4. These findings suggested that the degree of lung injury was reduced during the acute inflammatory reaction when NFkappaB was inhibited, and that the expression of sphingomyelin synthase 2 may affect the induction of the NFkappaB pathway by lipopolysaccharide through CD14 (show CD14 Proteins).

  5. Study provides a mouse model for fetal alcohol spectrum disorder. Due to the accumulation of ceramide in vivo, SMS2 knockout mice allows to investigate how ceramide regulates alcohol-induced neural apoptosis.

  6. study provided evidence that genetic inhibition of SMS2 elevated glucose clearance through activation of glucose uptake into insulin (show INS Proteins)-targeted tissues such as skeletal muscle by a mechanism independent of hepatic SMS2

  7. Thus, imaging mass spectrometry can provide visual assessment of the contribution of SMS2 on acyl-chain- and region-specific sphingomyelin metabolism in the kidneys

  8. study reveals that all mouse SMS family members (SMSr, SMS1, and SMS2) have CPE synthase activity

  9. Increasing ceramide levels in the liver can be achieved by SMS2 inhibition to prevent liver steatosis via PPARgamma (show PPARG Proteins) suppression.

  10. Data show that LCAT (show LCAT Proteins) activity was significantly higher in long chain base biosynthesis protein 2 (Sptlc2 (show SPTLC2 Proteins))+/- and sphingomyelin synthase 2 (Sms2)-/- mice, but markedly lower in ApoE (show APOE Proteins)-/- and Ldlr (show LDLR Proteins)-/- mice.

Sphingomyelin Synthase 2 (SGMS2) Protein Profile

Protein Summary

Sphingomyelin, a major component of cell and Golgi membranes, is made by the transfer of phosphocholine from phosphatidylcholine onto ceramide, with diacylglycerol as a side product. The protein encoded by this gene is an enzyme that catalyzes this reaction primarily at the cell membrane. The synthesis is reversible, and this enzyme can catalyze the reaction in either direction. The encoded protein is required for cell growth. Three transcript variants encoding the same protein have been found for this gene. There is evidence for more variants, but the full-length nature of their transcripts has not been determined.

Gene names and symbols associated with SGMS2

  • sphingomyelin synthase 2 (sgms2)
  • sphingomyelin synthase 2 (SGMS2)
  • sphingomyelin synthase 2 (Sgms2)
  • 4933405A16Rik protein
  • 5133401H06Rik protein
  • AI854299 protein
  • RGD1305778 protein
  • SMS2 protein
  • spermatin protein

Protein level used designations for SGMS2

sphingomyelin synthase 2 , phosphatidylcholine:ceramide cholinephosphotransferase 2 , phosphatidylcholine:ceramide cholinephosphotransferase 2-like , SM synthase

496853 Xenopus (Silurana) tropicalis
695947 Macaca mulatta
735414 Pan troglodytes
100072971 Equus caballus
100079264 Ornithorhynchus anatinus
100400486 Callithrix jacchus
100446194 Pongo abelii
100466473 Ailuropoda melanoleuca
100593842 Nomascus leucogenys
166929 Homo sapiens
556193 Danio rerio
422529 Gallus gallus
478505 Canis lupus familiaris
100518796 Sus scrofa
520954 Bos taurus
74442 Mus musculus
310849 Rattus norvegicus
100715504 Cavia porcellus
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