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S1PR3 encodes a member of the EDG family of receptors, which are G protein-coupled receptors.
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Sphingosine-1-phosphate receptor 3 (S1PR3) mediates multiple aspects of the inflammatory response during sepsis.
in breast cancer cells overexpression of S1P3 and its activation by S1P (show MBTPS1 Antibodies) has pro-inflammatory and pro-metastatic potential by inducing COX-2 (show COX2 Antibodies) expression and PGE2 signaling via EP2 (show SPAG11B Antibodies) and EP4 (show PTGER4 Antibodies).
S1PR1 (show S1PR1 Antibodies)/3 silencing alters proliferation, adhesion, viability and lateral motility in estrogen receptor (show ESR1 Antibodies)-negative MCF-7 and estrogen receptor (show ESR1 Antibodies)-positive MDA-MB-231 breast cancer cells.
High S1PR3 expression is associated with increased lung adenocarcinoma.
The S1P1,3 activation results in Akt (show AKT1 Antibodies) phosphorylation and subsequent activation of eNOS (show NOS3 Antibodies) via phosphorylation at serine(1177) and dephosphorylation at threonine(495).
HDL (show HSD11B1 Antibodies)-associated ApoM (show APOM Antibodies) is anti-apoptotic by delivering sphingosine 1-phosphate to S1P1 (show S1PR1 Antibodies) and S1P3 receptors on vascular endothelium.
The study shows that S1P receptor 3 (S1PR3) mRNA is overexpressed in EBV-positive NPC (show NPC1 Antibodies) patient-derived xenografts and a subset of primary NPC (show NPC1 Antibodies) tissues, and that knockdown of S1PR3 suppressed the activation of AKT (show AKT1 Antibodies) and the S1P (show MBTPS1 Antibodies)-induced migration of NPC (show NPC1 Antibodies) cells.
S1pr3 promotes leukocyte rolling by mobilization of endothelial P-selectin (show SELP Antibodies).
Stimulation with sphingosine-1-phosphate enhances cancer stem cells via S1PR3 and subsequent Notch1 (show NOTCH1 Antibodies) activation.
TRPC1 (show TRPC1 Antibodies) functions as a major regulator of S1P3 and VEGFR2 (show KDR Antibodies) expression.
There is considerable sexual dimorphism in the vascular and metabolic responses of aged mice and that reduced signaling through S1PR3 could be one mechanism to explain these effects.
The findings of this study demonstrated that S1P3 and Sphk1 (show SPHK1 Antibodies) are mediators of inflammatory signaling and are upregulated in astrocytes in response to injury.
The absence of S1P3 appears responsible for a lower availability of calcium during fatigue.
These results highlight an important role for S1PR3 in Hematopoietic stem and progenitor cell niche occupancy.
S1P3 deletion protects mouse soleus from age-related drop in muscle mass, force, and regenerative capacity.
The finding that S1P3 receptor- and Galpha13 (show GNA13 Antibodies)-mediated RhoA (show RHOA Antibodies) activation is responsible for protection against ischemia/reperfusion suggests that selective targeting of S1P3 receptors could provide therapeutic benefits in ischemic heart disease.
The role of the S1PR3/PDGFR-beta (show PDGFRB Antibodies)/Akt (show AKT1 Antibodies) pathway in sphingosine-1-phosphate -induced endothelial progenitor cells migration and angiogenesis
P2RY8 promotes clustering of activated B cells within follicles in a follicular dendritic cell (FDC)-dependent manner.
Smad3 (show SMAD3 Antibodies) deficiency leads to mandibular condyle degradation via the sphingosine 1-phosphate (S1P (show S1PR1 Antibodies))/S1P3 signaling axis
This gene encodes a member of the EDG family of receptors, which are G protein-coupled receptors. This protein has been identified as a functional receptor for sphingosine 1-phosphate and likely contributes to the regulation of angiogenesis and vascular endothelial cell function.
sphingosine-1-phosphate receptor 3
, sphingosine 1-phosphate receptor 3-like
, G protein-coupled receptor, endothelial differentiation gene-3
, S1P receptor 3
, S1P receptor EDG3
, S1P receptor Edg-3
, endothelial differentiation G-protein coupled receptor 3
, endothelial differentiation, sphingolipid G-protein-coupled receptor, 3
, sphingosine 1-phosphate receptor 3
, sphingosine 1-phosphate receptor Edg-3
, S1p receptor 3
, endothelial differentiation sphingolipid G-protein-coupled receptor 3
, lysophospholipid receptor B3