Spire Homolog 1 (Drosophila) Proteins (SPIRE1)

Spire proteins, such as SPIRE1, are highly conserved between species. Additionally we are shipping Spire Homolog 1 (Drosophila) Antibodies (26) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SPIRE1 68166  
SPIRE1 56907 Q08AE8
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Top Spire Homolog 1 (Drosophila) Proteins at antibodies-online.com

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$13,984.89
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$9,797.11
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 2 to 3 Days
$814.00
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
Details

SPIRE1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
, ,

More Proteins for Spire Homolog 1 (Drosophila) (SPIRE1) Interaction Partners

Mouse (Murine) Spire Homolog 1 (Drosophila) (SPIRE1) interaction partners

  1. Spire-1 is specifically recruited at invadosomes and is part of a multi-molecular complex containing Src kinase, the formin mDia1 and actin.

  2. analysis of the molecular basis of the Spir1/formin-2 interaction

  3. Spire1 and Spire2 (show SPIRE2 Proteins) drive two critical steps of asymmetric oocyte division.

  4. By analyzing the expression of the spir-1 gene it was shown that spir-1 and formin-2 have a nearly identical expression pattern during mouse embryogenesis and in the adult brain.

Human Spire Homolog 1 (Drosophila) (SPIRE1) interaction partners

  1. Data suggest formin homology domain (FH2) of Fmn2 binds actin at filament barbed end as weak capper and plays a role in displacing WASP homology domain 2 (WH2) domains of Spire-1 from actin; competitive binding of Fmn2 vs Spire-1 aids actin assembly.

  2. This DNA damage-induced nuclear actin assembly requires two biologically and physically linked nucleation factors: Formin-2 and Spire-1/Spire-2.

  3. The authors propose Spire1C isoform cooperates with INF2 to regulate actin assembly at endoplasmic reticulum-mitochondrial contacts.

  4. Spire recruits Fmn2 and facilitates its association with actin filaments barbed ends.

  5. Spire-1 is specifically recruited at invadosomes and is part of a multi-molecular complex containing Src kinase, the formin mDia1 and actin.

  6. analysis of the molecular basis of the Spir1/formin-2 interaction

  7. The multifunctional character of the WH2 domains allows Spire to sequester four G-actin (show ACTB Proteins) subunits binding cooperatively in a tight SA(4) complex and to nucleate, sever, and cap filaments at their barbed ends.

  8. both mammalian Spir proteins, Spir-1 and Spir-2, interact with mammalian Fmn subgroup proteins formin-1 and formin-2

Spire Homolog 1 (Drosophila) (SPIRE1) Protein Profile

Protein Summary

Spire proteins, such as SPIRE1, are highly conserved between species. They belong to the family of Wiskott-Aldrich homology region-2 (WH2) proteins, which are involved in actin organization (Kerkhoff et al., 2001

Gene names and symbols associated with SPIRE1

  • spire homolog 1 (Drosophila) (Spire1)
  • spire-type actin nucleation factor 1a (spire1a)
  • spire type actin nucleation factor 1 (SPIRE1)
  • 6030430B19Rik protein
  • AI415299 protein
  • AU022898 protein
  • AW550622 protein
  • si:ch211-215i13.1 protein
  • si:zc215i13.1 protein
  • Spir-1 protein
  • Spir-2 protein
  • spire1 protein
  • zgc:153436 protein

Protein level used designations for SPIRE1

protein spire homolog 1 , spire homolog 1 , spire actin nucleation factor 1 , spire family actin nucleation factor 1

GENE ID SPECIES
68166 Mus musculus
557962 Danio rerio
56907 Homo sapiens
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