anti-SplA/ryanodine Receptor Domain and SOCS Box Containing 1 (SPSB1) Antibodies

Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Additionally we are shipping SPSB1 Proteins (7) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SPSB1 80176 Q96BD6
SPSB1 74646 Q9D5L7
SPSB1    
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Top anti-SPSB1 Antibodies at antibodies-online.com

Showing 9 out of 15 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-SPSB1 Antibody Titration: 1.0 ug/ml Positive Control: Fetal Lung 100 μL Log in to see 2 to 3 Days
$319.00
Details
Chicken Rabbit Un-conjugated WB   50 μg Log in to see 11 to 14 Days
$551.83
Details
Human Rabbit Un-conjugated WB Western blot analysis of extracts of various cell lines, using SPSB1 antibody. 200 μL Log in to see 12 to 14 Days
$438.90
Details
Human Rabbit Un-conjugated WB Western blot analysis of extracts of mouse heart, using SPSB1 antibody (ABIN4905289) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 90s. 100 μL Log in to see 11 to 13 Days
$366.77
Details
Human Mouse Un-conjugated ELISA Detection limit for recombinant GST tagged SPSB1 is 1 ng/ml as a capture antibody. 100 μg Log in to see 11 to 12 Days
$440.00
Details
Human Mouse Un-conjugated WB Western Blot analysis of SPSB1 expression in transfected 293T cell line by SPSB1 MaxPab polyclonal antibody.Lane 1: SPSB1 transfected lysate(30.14 KDa).Lane 2: Non-transfected lysate. 50 μg Log in to see 11 to 12 Days
$440.00
Details
Human Mouse Un-conjugated ELISA   100 μg Log in to see 11 to 16 Days
$625.43
Details
Human Rabbit Un-conjugated WB   100 μL Log in to see 13 to 14 Days
$393.25
Details
Human Rabbit Un-conjugated ELISA, WB   100 μg Log in to see 11 to 16 Days
$405.08
Details

More Antibodies against SPSB1 Interaction Partners

Human SplA/ryanodine Receptor Domain and SOCS Box Containing 1 (SPSB1) interaction partners

  1. EGF signaling upregulates an E3 ubiquitin (Ub) ligase adaptor, SPRY domain-containing SOCS box protein 1 (SPSB1), which recruits Elongin B/C-Cullin complexes to conjugate lysine 29-linked poly Ubiquitin chains onto hnRNP A1.

  2. SPSB1 negatively regulates the TGF-beta signaling pathway through its interaction with both endogenous and overexpressed TbetaRII (and not TbetaRI) via its Spry domain.

  3. Findings define a novel pathway that contributes to breast cancer recurrence and provide evidence implicating SPSB proteins in cancer.

  4. SSB1/2 is part of an ssDNA-binding heterotrimeric complex, SOSS which is involved in the maintenance of genome stability.

Mouse (Murine) SplA/ryanodine Receptor Domain and SOCS Box Containing 1 (SPSB1) interaction partners

  1. Collectively, Ssb1 and Ssb2 control crucial aspects of Hematopoietic stem and progenitor cells function, including proliferation and survival in vivo by resolving replicative stress to maintain genomic stability.

  2. SPSB1 negatively regulates the TGF-beta signaling pathway through its interaction with both endogenous and overexpressed TbetaRII (and not TbetaRI) via its Spry domain.

  3. Findings define a novel pathway that contributes to breast cancer recurrence and provide evidence implicating SPSB proteins in cancer.

  4. Collectively, these results demonstrate essential roles of Ssb1 in embryogenesis, spermatogenesis, and genome stability in vivo.

  5. These results suggest that SPSB1 acts through a negative-feedback loop that, together with SPSB2, controls the extent of iNOS induction and nitric oxide production.

  6. SPSB1 and SPSB4 bind strongly to both Par-4 and VASA peptides.

  7. Spsb1 is responsive to stress caused by ethanol exposure in the mouse brain, which suggests that Spsb genes have acquired different regulatory mechanisms.

SPSB1 Antigen Profile

Protein Summary

Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).

Gene names and symbols associated with SPSB1

  • splA/ryanodine receptor domain and SOCS box containing 1 (SPSB1) antibody
  • splA/ryanodine receptor domain and SOCS box containing 1 (Spsb1) antibody
  • 1110014L01Rik antibody
  • 4930422J18Rik antibody
  • AI596360 antibody
  • AI854583 antibody
  • SSB-1 antibody
  • SSB1 antibody

Protein level used designations for SPSB1

SPRY domain-containing SOCS box protein 1 , SPRY domain-containing SOCS box protein SSB-1 , novel SPRY domain containing protein , SSB-1

GENE ID SPECIES
80176 Homo sapiens
74646 Mus musculus
504407 Bos taurus
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