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The product of SHFM1 has been localized within the split hand/split foot malformation locus SHFM1 at chromosome 7. Additionally we are shipping SHFM1 Antibodies (43) and SHFM1 Proteins (7) and many more products for this protein.
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Promoter methylation plays a role in modulating DSS1 gene expression. Promoter hypomethylation is a frequent event in melanoma and squamous cell carcinoma and is closely linked to poor prognosis.
DSS1 is a multifunctional and intrinsically disordered protein. (Review)
three phenotypic subregions within the SHFM1 locus link both size and genomic position of the chromosomal aberrations to the clinical variability seen in SHFM1 patients
SHFM1 confers cell cycle progression and resistance to p53 stabilizing drugs in gastric cancer cells.
by targeting RPA and mimicking DNA, DSS1 functions with BRCA2 in a two-component homologous recombination mediator complex in genome maintenance and tumor suppression
Breast cancers with high DSS1 expression have worse prognosis and shorter relapse-free survival times.
Mutation screening of the SHFM1 gene in familial breast/ovarian cancer cases.
DSS1 protein is critically involved in the maintenance of the transformed phenotype in cervical cancer cells, and that it might be a specific, robust and reliable marker for early detection, diagnosis and trea
DSS1 has a role in homologous recombinational repair in human cells
p63 binds to an enhancer element in the SHFM1 locus and this element controls expression of DLX6 and DLX5 which are important for limb development.
The DSS1 c.143G>A variant is associated with reduced DSS1 expression at RNA and protein levels and altered traffic of the DSS1 protein from the cytoplasm to the nucleus. These alterations could impair DSS1 function and may be implicated in skin cancer.
3.1 angstrom crystal structure of approximately 90-kilodalton BRCA2 domain bound to DSS1, which reveals three oligonucleotide-binding (OB) folds and a helix-turn-helix (HTH) motif
DSS1, responsible for autism, was studied in a linkage disequilibrium model.
DSS1 has been shown to interact with components of the 26S proteasome in Saccharomyces cerevisiae and in human tumour cells
Data suggest that the R3IM motif of DSS1, in conjunction with the complexes of 19S RP and 20S core particle, regulates proteasome interaction through RPN3/S3 molecule, and utilizes a specific subset of poly-ubiquitinated p53 as a substrate.
expression in keratinocyte progenitor cells, with possible involvement in early skin tumorigenesis
The product of this gene has been localized within the split hand/split foot malformation locus SHFM1 at chromosome 7. It has been proposed to be a candidate gene for the autosomal dominant form of the heterogeneous limb developmental disorder split hand/split foot malformation type 1. In addition, it has been shown to directly interact with BRCA2. It also may play a role in the completion of the cell cycle.
26S proteasome complex subunit DSS1
, deleted in split hand/split foot protein 1
, deleted in split-hand/split-foot 1
, split hand/foot deleted protein 1
, split hand/foot malformation type 1 protein
, candidate for split hand/foot malformation type 1
, 26 proteasome complex subunit DSS1
, split hand/foot malformation type 1 protein homolog
, split hand/foot malformation (ectrodactyly) type 1
, deleted in split hand/split foot protein 1 homolog
, split hand/foot deleted gene 1
, split hand/foot deleted protein 1 homolog
, 26S proteasome complex subunit SEM1
, split hand/foot malformation (ectrodactyly) type 1 S homeolog