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DNA-binding component of the FA core complex involved in DNA damage repair and genome maintenance. Additionally we are shipping STRA13 Antibodies (13) and STRA13 Kits (12) and many more products for this protein.
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MHF prefers branched DNA over dsDNA because it engages two duplex arms. MHF engages DNA forks or various four-way junctions independent of the junction-site structure. The DNA-binding interface of MHF is important for cellular resistance to DNA damage.
The MHF complex, which is a heterotetramer that comprises two MHF1-MHF2 heterodimers, is remodeled by FANCM to favor recognition of branched DNA over dsDNA.
CENPX assembly in living human cells, revealing a window in S phase and G2 in which de novo assembly of the complex from a soluble precursor occurs through a dynamic exchange mechanism.
It discusses current knowledge of the biological roles of CENP-S and CENP-X and how their dual existence may be a common feature of CCAN (constitutive centromere-associated network) proteins.
A long, positively charged patch exposed on the surface of the (MHF1-MHF2) complex plays a critical role in double-stranded DNA binding to chromatin.
MHF1 and MHF2 form a compact tetramer to which FANCM-F binds through a 'dual-V' shaped structure.
provide biochemical evidence that MHF1 and MHF2 assemble into a heterodimer that binds DNA and enhances the DNA branch migration activity of FANCM.
Results identified a centromere protein S (CENP-S)-containing subcomplex that includes the new constitutive kinetochore protein CENP-X [Stra13]
Identification of human and mouse homologs of clone D9 of a murine promyelocyte cell line that was upregulated by retinoic acid.
DNA-binding component of the FA core complex involved in DNA damage repair and genome maintenance. Recruited to forks stalled by DNA interstrand cross-links, and required for cellular resistance to such lesions. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. Component of the APITD1/CENPS complex that is essential for the stable assembly of the outer kinetochore. Plays an important role in mitotic progression and chromosome segregation.
FANCM-interacting histone fold protein 2
, Fanconi anemia-associated polypeptide of 10 kDa
, centromere protein X
, retinoic acid-inducible gene D9 protein homolog
, stimulated by retinoic acid 13 homolog
, stimulated by retinoic acid gene 13 protein homolog
, immediate-early-response protein D9
, retinoic acid-inducible gene D9 protein
, basic helix-loop-helix domain containing, class B, 2