anti-Stromal Interaction Molecule 2 (Stim2) Antibodies

Human Stromal Interaction Molecule 2 (Stim2) interaction partners

1. With STIM2 being essential for life, but apparently not for development, newly available data demonstrate a complex and still intriguing behaviour that this review summarizes, updating current knowledge of STIM2 function [review]

2. The STIM2 protein play important roles in TGF-beta (show TGFB1 Antibodies)-induced EMT (show ITK Antibodies) and these effects are related to both store-operated calcium entry and non-store-operated calcium entry.

3. What is less clear is how the spatial and temporal spread of intracellular Ca(2 (show CA2 Antibodies)+) is shaped and regulated by differential expression of the individual SOCE genes and their splice variants, their heteromeric combinations and pre- and posttranslational modifications. This review focuses on principle mechanisms regulating expression, splicing, and targeting of Ca(2 (show CA2 Antibodies)+) release-activated Ca(2 (show CA2 Antibodies)+) (CRAC) channels.

4. While STIM1 (show STIM1 Antibodies) is a full Orai1 (show ORAI1 Antibodies)-agonist, leucine-replacement of this crucial residue in STIM2 endows it with partial agonist properties, which may be critical for limiting Orai1 (show ORAI1 Antibodies) activation stemming from its enhanced sensitivity to store-depletion

5. STIM2.1 cannot activate Orai1 (show ORAI1 Antibodies) due to splicing in residues within the channel-activating domain (CAD (show CAD Antibodies)). STIM2.1 confers a calcium dependent dominant-negative function on both STIM1 (show STIM1 Antibodies) and STIM2 (STIM2.2). Affinity of the STIM2.1 calmodulin binding site within the CAD (show CAD Antibodies) domain is increased compared to STIM2.2.

6. STIM2 enhances receptor-stimulated Ca(2 (show CA2 Antibodies)) signaling by promoting recruitment of STIM1 (show STIM1 Antibodies) to the endoplasmic reticulum-plasma membrane junctions.

7. STIM2beta does not by itself strongly bind Orai1 (show ORAI1 Antibodies), it is recruited to Orai1 (show ORAI1 Antibodies) channels by forming heterodimers with other STIM isoforms.

8. Imin channels are regulated by STIM2, TRPC3 (show TRPC3 Antibodies)-containing INS (show INS Antibodies) channels are induced by STIM1 (show STIM1 Antibodies), and TRPC1 (show TRPC1 Antibodies)-composed Imax channels are activated by both STIM1 (show STIM1 Antibodies) and STIM2.

9. The higher amplitude of store-operated Ca2 (show CA2 Antibodies)+ entry was associated to the over-expression for Stim2, Orai2 (show ORAI2 Antibodies)-3, and TRPC1 (show TRPC1 Antibodies) while Stim2 levels remained constant and Stim1 (show STIM1 Antibodies), Orai1 (show ORAI1 Antibodies), Orai3 (show ORAI3 Antibodies), TRPC1 (show TRPC1 Antibodies) and TRPC4 (show TRPC4 Antibodies) proteins were over-expressed in primary myelofibrosis.

10. the reciprocal shift in transient receptor potential channel 1 (TRPC1 (show TRPC1 Antibodies)) and stromal interaction molecule 2 (STIM2) contributes to Ca2 (show CA2 Antibodies)+ remodeling and cancer hallmarks in colorectal carcinoma cells

Mouse (Murine) Stromal Interaction Molecule 2 (Stim2) interaction partners

1. Stim1 (show STIM1 Antibodies) and Stim2 deficient B cells show an accelerated pace of affinity maturation but do not have dramatically impaired antibody production to T-independent antigen immunization

2. We found that STIM2 is required for the stable expression of both LTP (show SCP2 Antibodies) and LTD at CA3 (show CA3 Antibodies)-CA1 (show CA1 Antibodies) hippocampal synapses. Altered plasticity in Stim2 cKO mice is associated with subtle alterations in the shape and density of dendritic spines in CA1 (show CA1 Antibodies) neurons.

3. neutrophil cytokine production required STIM2, but not STIM1 (show STIM1 Antibodies), at least in part as a result of redox regulation of cytokine gene expression

4. Expression of STIM2 protein rescued CaMKII (show CAMK2G Antibodies) activity and protected mushroom spines from Abeta42 oligomer toxicity in vitro and in vivo.

5. SOCE blockers or ablation of STIM1 (show STIM1 Antibodies), STIM2, or Orai1 (show TMEM132A Antibodies) severely impaired nucleotide-induced migration and phagocytosis in microglia.

6. The data from this study indicate that upregulation of STIM2 and Orai2 (show ORAI2 Antibodies) is involved in the phenotypic transition of pulmonary arterial smooth muscle cells from a contractile state to a proliferative state.

7. STIM1 (show STIM1 Antibodies), STIM2, and CRAC channel function play distinct but synergistic roles in CD4 (show CD4 Antibodies)+ and CD8 (show CD8A Antibodies)+ T cells during antiviral immunity

8. STIM2 deficiency significantly delays onset and attenuates the clinical course of experimental allergic encephalitis.

9. Using mice lacking STIM1 (show STIM1 Antibodies) and its homologue STIM2, authors find that store-operated calcium entry in CD8 (show CD8A Antibodies)(+) T cells is required to prevent the engraftment of melanoma and colon carcinoma cells and to control tumour growth.

10. STIM1 (show STIM1 Antibodies) and STIM2-mediated store-operated Ca2 (show CA2 Antibodies)+ influx, leading to efficient activation of NFAT (show NFATC1 Antibodies) (nuclear factor of activated T cells), is critical for the postselection maturation of agonist-selected T cells.