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Contributes to the lung's defense against inhaled microorganisms. Additionally we are shipping Surfactant Protein D Antibodies (128) and Surfactant Protein D Proteins (14) and many more products for this protein.
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Human SFTPD ELISA Kit for Sandwich ELISA - ABIN1000111
Ju, Liu, Chen: Serum surfactant protein D: biomarker of chronic obstructive pulmonary disease. in Disease markers 2012
SP-D increases the formation of nuclear and membrane blebs. Inhibition of caspase-8 (show CASP8 ELISA Kits) confirms the effect of SP-D is unique to the caspase-8 (show CASP8 ELISA Kits) pathway.
Findings indicate serum pulmonary surfactant protein D (SP-D, SFTPD) level as a potential marker to estimate the efficacy of epidermal growth factor receptor (EGFR (show EGFR ELISA Kits))-tyrosine kinase (show TXK ELISA Kits) inhibitor (TKIs).
Patients with SP-D 11Thr/Thr (show TRH ELISA Kits) genotype were more susceptible to acute kidney injury (AKI). Compared with healthy controls, serum SP-D levels at day 1, 3 and 7 were significantly elevated in AKI patients.
This review intends to provide a current overview of the genetics, structure and extra-pulmonary functions of the surfactant collectin (show MBL2 ELISA Kits) proteins.
Meta-analysis found that serum SP-A/D detection might be useful for differential diagnosis and prediction of survival in patients with idiopathic pulmonary fibrosis.
The findings suggest that SP-D inhibits LPS (show IRF6 ELISA Kits)-stimulated production of interleukin-12p40 via the SIRPalpha/ROCK/ERK (show EPHB2 ELISA Kits) signaling pathway.
Efficient lipopolysaccharide recognition by SP-D requires multiple binding interactions utilizing the three major ligand-binding determinants in the SP-D binding pocket, with Ca-dependent binding of inner-core heptose accompanied by interaction of anhydro-Kdo (4,7-anhydro-3-deoxy-d-manno (show MAN2A1 ELISA Kits)-oct-2-ulosonic acid) with Arg343 and Asp325.
SP-D levels in bronchoalveolar lavage samples were significantly lower in severe asthma compared with healthy controls and mild asthma. Serum SP-D was significantly increased in severe asthma compared with healthy controls and mild asthma.
SP-A (+186A/G) and SP-B (1580C/T) polymorphisms are strongly associated with the risk of respiratory distress syndrome (RDS (show PRPH2 ELISA Kits)) in preterm infants. Notably, reduced serum SP-A levels were correlated with a high risk of RDS (show PRPH2 ELISA Kits) and may serve as novel biomarkers for RDS (show PRPH2 ELISA Kits) detection and monitoring.
Obstructive sleep apnea-hypopnea syndrome pathogenesis was associated with changes in NF-kappaB (show NFKB1 ELISA Kits), HIF-1alpha (show HIF1A ELISA Kits), and SPD (show HOXD13 ELISA Kits) protein expression level
Elevation of SP-D is found in bronchoalveolar lavage fluid from inoculated lobes of calves infected with bovine adenovirus type 3.
The bSP (show KLK6 ELISA Kits)-D gene has 9 exons spanning about 10.5 kb on chromosome 28 at position q1.8. The 5'-upstream sequence has cis (show CISH ELISA Kits)-regulatory elements. It has 2 (show HAS2 ELISA Kits) polymorphisms in the carbohydrate recognition domain (242 Glu (show DCTN1 ELISA Kits)/Val & 268 Ala/Gly).
The authors demonstrated that the number and position of glycosylation sites determine viral susceptibility to the neutralizing activity of porcine SP-D.
Data show that interactions of surfactant protein D (pSP-D) with influenza A virus mediated by the N-linked carbohydrate moiety in pSP-D depend on the terminal sialic acids present on this moiety.
The presence of SP-D in endothelial cells which is NO-, PI(3 (show PI3 ELISA Kits))K/Akt (show AKT1 ELISA Kits)- and Erk (show MAPK1 ELISA Kits)-dependent is demonstrated. It suggests a protective role of SP-D in these cells.
The importance of SP-D in innate immunity is underlined by its expression at the potential ports of entry of pathogens: lung, tongue, intestinal tract, thymus, skin, gall bladder, lacrimal gland, esophagus, stomach, kidney, liver, prostate and spleen.
Our study provides comprehensive information regarding spatial and temporal expression of collectins (SP-A (show SFTPA1 ELISA Kits), SP-D and MBL-A) and their cellular sources in murine testis. Positive regulation by testosterone and alteration in their level upon LPS (show TLR4 ELISA Kits) challenge are clues relevant to suggest their involvement in testicular immune privilege.
Our data may promote further studies on the morphological development of the aging lung and the role of SP-D in this process.
The experimentally induced alterations were more severe in the SP-D(-/-) than in the WT mice, particularly with respect to the surfactant-storing lamellar bodies which were sometimes extremely enlarged in SP-D(-/-) mice.
these results demonstrate SP-D plays protective roles by inhibiting apoptosis and modulating NF-kappaB-mediated inflammation in CLP-induced acute pancreatic injury .
SP-A (show SFTPA1 ELISA Kits)/D double knock-out mice showed increased susceptibility to urinary tract infection
Human and murine data together indicate that SP-A, SP-D and MBL are synthesized in early gestational tissues, and may contribute to regulation of immune response at the feto-maternal interface during pregnancy.
The presence of SP-A (show SFTPA1 ELISA Kits) and SP-D in the murine decidua is likely to play a protective role against intrauterine infection during pregnancy.
our results demonstrate that SFTPD deficiency affects female fertility, highlighting roles for SFTPD in ovarian and uterine physiology
the collectin (show MBL2 ELISA Kits) Surfactant Protein D is an essential component of host innate immunity to helminths
SP-D protects the ocular surface from S. aureus infection.
Surfactant protein D and haptoglobin (show HP ELISA Kits) serum concentrations could be a diagnostic aid for equine inflammatory airway disease.
The levels of surfactant protein D and serum amyloid A protein in normal horses and those with bacterial pneumonia are reported.
Contributes to the lung's defense against inhaled microorganisms. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties.
, lung surfactant protein D
, pulmonary surfactant apoprotein
, pulmonary surfactant-associated protein D
, surfactant, pulmonary-associated protein D
, surfactant-associated protein, pulmonary 4
, pulmonary surfactant protein D
, surfactant associated protein D
, surfactant protein D
, carbohydrate recognition domain
, LOW QUALITY PROTEIN: pulmonary surfactant-associated protein D