anti-Synuclein, alpha Interacting Protein (SNCAIP) Antibodies

Human Synuclein, alpha Interacting Protein (SNCAIP) interaction partners

1. Differential expression of synphilin-1 isoforms (and alpha-synuclein and parkin (show PARK2 Antibodies)) was found in multiple system atrophy brains compared to control brain.

2. Synphilin-1 binds ATP, but not CTP (show CDS1 Antibodies).

3. Overexpression of human synphilin-1 in mice resulted in hyperphagia and obesity.

4. Overexpression of SP1 (show PSG1 Antibodies) in neurons, but not peripheral cells, increased the body weight of flies compared with that of non-transgenic controls. SP1 (show PSG1 Antibodies) increased food intake but did not affect locomotor activity

5. Although serine-129 phosphorylation of alpha-synuclein facilitates tubulin polymerization promoting protein (TPPP (show Tppp Antibodies))-mediated alpha-SYN oligomerization, this modification does not seem to play an inevitable role in the early step of alpha-SYN oligomer formation.

6. Mutation screening of SNCAIP identifies novel sequence variants using a bioinformatic approach; further studies are necessary to determine their possible functional consequences in South African patients with Parkinson's disease.

7. Neuronal survival factor MEF2D is decreased in human and experimental Parkinson's disease, a decrease that is specifically associated with alpha-synuclein accumulation and aggregation.

8. Synphilin-1 inhibits alpha-synuclein degradation by the proteasome.

9. Knockdown of Herp (show HERPUD1 Antibodies) gene unexpectedly facilitated the degradation of synphilin-1, and improved cell viability during proteasomal inhibition.

10. Data show that periphilin (show PPHLN1 Antibodies) displays an overlapping expression pattern with synphilin-1 in cellular and animal models and in Lewy bodies of Parkinson's disease (PD) patients, and support involvement of periphilin (show PPHLN1 Antibodies) in PD.

Mouse (Murine) Synuclein, alpha Interacting Protein (SNCAIP) interaction partners

1. Mulberry fruit extract had inhibitory effects on the up-regulation of both alpha-synuclein and ubiquitin, the major components of lewy bodies, in substantia nigra and striatum in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine/probenecid model of early Parkinson's disease .

2. 2,3,7,8-tetrachlorodibenzo-p-dioxin promoted synphilin-1 degradation in an aryl hydrocarbon receptor (show AHR Antibodies)-dependent way.

3. This study shows that alpha-synuclein is present in cerebellar glutamatergic terminals.

4. These results suggest that increased levels of NUB1 play a potential role in degradation of detergent-insoluble alpha-synuclein in vivo, although it is insufficient to degrade abnormal alpha-synuclein in Lewy body disease model mice.

5. SP1 (show SP1 Antibodies) results in a CCK (show CCK Antibodies) response deficiency that may contribute to the increased meal size and overall hyperphagia in synphillin-1 transgenic mice

6. TEM analysis of protein:inhibitor assays demonstrated that scyllo-inositol inhibits the aggregation of alpha-synuclein, suggesting the therapeutic potential of the small molecule in PD.

7. We exploited atomic force microscopy (AFM) for the selective, nanoscale confinement of alpha-Synuclein on gold to study the early stages of alpha-Synuclein aggregation and the effect of small molecules, like dopamine, on the aggregation process.

8. Sncaip physically interacts with PPP1 and affects PPP1 sorting to subcellular compartments.

9. Studies identify a novel function of synphilin-1 in controlling food intake and body weight, and may provide a unique obesity model for future studies of obesity pathogenesis and therapeutics.

10. Synphilin-1 can diminish the severity of alpha-synucleinopathy and play a neuroprotective role against A53T alpha-synuclein toxicity in vivo.