anti-Synuclein, alpha Interacting Protein (SNCAIP) Antibodies

Human Synuclein, alpha Interacting Protein (SNCAIP) interaction partners

1. results indicated that synphilin-1 may play neuroprotective roles in Parkinson Disease pathogenesis by inhibiting ROS production and apoptosis.

2. Differential expression of synphilin-1 isoforms (and alpha-synuclein and parkin) was found in multiple system atrophy brains compared to control brain.

3. Synphilin-1 binds ATP, but not CTP.

4. Overexpression of human synphilin-1 in mice resulted in hyperphagia and obesity.

5. Overexpression of SP1 in neurons, but not peripheral cells, increased the body weight of flies compared with that of non-transgenic controls. SP1 increased food intake but did not affect locomotor activity

6. Although serine-129 phosphorylation of alpha-synuclein facilitates tubulin polymerization promoting protein (TPPP)-mediated alpha-SYN oligomerization, this modification does not seem to play an inevitable role in the early step of alpha-SYN oligomer formation.

7. Mutation screening of SNCAIP identifies novel sequence variants using a bioinformatic approach; further studies are necessary to determine their possible functional consequences in South African patients with Parkinson's disease.

8. Neuronal survival factor MEF2D is decreased in human and experimental Parkinson's disease, a decrease that is specifically associated with alpha-synuclein accumulation and aggregation.

9. Synphilin-1 inhibits alpha-synuclein degradation by the proteasome.

10. Knockdown of Herp gene unexpectedly facilitated the degradation of synphilin-1, and improved cell viability during proteasomal inhibition.

11. Data show that periphilin displays an overlapping expression pattern with synphilin-1 in cellular and animal models and in Lewy bodies of Parkinson's disease (PD) patients, and support involvement of periphilin in PD.

12. expression of synphilin-1 shortens N1E-115 cell division doubling time, promotes neurite outgrowth, and protects against Rotenone-induced toxicity; synphilin-1 displays a neurotrophic effect in vitro, may play a neuroprotective role in Parkinson's disease

13. alpha-synuclein-synphilin-1 interaction significantly promotes the formation of cytoplasmic alpha-synuclein inclusions, which may have implications for Lewy body formation in neural cells

14. The amino acid sequence of synphilin-1 shows extensive homology with its human counterpart, especially in regions containing ankyrin-like motifs and the coiled-coil domain. Expression of mouse synphilin-1 in tissues is similar to its human counterpart.

15. results suggest that synphilin-1 has an important role in the formation of aggregates and cytotoxicity in Parkinson disease and that Dorfin may be involved in the pathogenic process by ubiquitylation of synphilin-1

16. a causative role of the R621C mutation in the synphilin-1 gene in Parkinson's disease

17. Changes in synuclein expression presage neurodegeneration in a Drosophila model of Parkinson disease.

18. Siah-1 was found to abrogate the inhibitory effects of synphilin-1 on dopamine release

19. role of aggresomes in cell viability was addressed in the context of over-expressing alpha-synuclein and its interacting partner synphilin-1

20. Casein kinase II (CKII) phosphorylates synphilin-1; beta subunit of this enzyme complex binds to synphilin-1. CKII-mediated phosphorylation of synphilin-1, rather than alpha-synuclein, modulates the aggregation into inclusion bodies.

Mouse (Murine) Synuclein, alpha Interacting Protein (SNCAIP) interaction partners

1. This study showed that A53T-alpha-synuclein overexpression in murine locus coeruleus induces Parkinson's disease-like pathology in neurons and glia.

2. The finding of increased spine pathology in Thy1-E57K is a new pathogenic function of oligomeric a-syn and precedes overt neurodegeneration. Thus, it may constitute a readout for therapeutic approache.

3. Mulberry fruit extract had inhibitory effects on the up-regulation of both alpha-synuclein and ubiquitin, the major components of lewy bodies, in substantia nigra and striatum in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine/probenecid model of early Parkinson's disease .

4. Enhanced aggregation and phosphorylation of alphaSyn causes the loss of dopaminergic neurons leading to the decline of motor coordination.

5. 2,3,7,8-tetrachlorodibenzo-p-dioxin promoted synphilin-1 degradation in an aryl hydrocarbon receptor-dependent way.

6. These results suggest that alpha-syn might participate in mechanisms of vulnerability of selected neuronal populations in AD and that reducing alpha-syn might be a potential approach to protecting these populations from the toxic effects of amyloid beta.

7. Neurons of A53T-alpha-Syn transgenic mice are more fragile to DNA damages.

8. This study shows that alpha-synuclein is present in cerebellar glutamatergic terminals.

9. These results suggest that increased levels of NUB1 play a potential role in degradation of detergent-insoluble alpha-synuclein in vivo, although it is insufficient to degrade abnormal alpha-synuclein in Lewy body disease model mice.

10. SP1 results in a CCK response deficiency that may contribute to the increased meal size and overall hyperphagia in synphillin-1 transgenic mice

11. TEM analysis of protein:inhibitor assays demonstrated that scyllo-inositol inhibits the aggregation of alpha-synuclein, suggesting the therapeutic potential of the small molecule in PD.

12. We exploited atomic force microscopy (AFM) for the selective, nanoscale confinement of alpha-Synuclein on gold to study the early stages of alpha-Synuclein aggregation and the effect of small molecules, like dopamine, on the aggregation process.

13. an important role of aSyn H50 in the pathogenesis of both sporadic and monogenic Parkinson's disease

14. Sncaip physically interacts with PPP1 and affects PPP1 sorting to subcellular compartments.

15. Studies identify a novel function of synphilin-1 in controlling food intake and body weight, and may provide a unique obesity model for future studies of obesity pathogenesis and therapeutics.

16. Synphilin-1 can diminish the severity of alpha-synucleinopathy and play a neuroprotective role against A53T alpha-synuclein toxicity in vivo.

17. synphilin-1 has a role in skill learning and motor performance

18. expression of synphilin-1 shortens N1E-115 cell division doubling time, promotes neurite outgrowth, and protects against Rotenone-induced toxicity; synphilin-1 displays a neurotrophic effect in vitro, may play a neuroprotective role in Parkinson's disease