anti-Synuclein, alpha Interacting Protein (SNCAIP) Antibodies

SNCAIP encodes a protein containing several protein-protein interaction domains, including ankyrin-like repeats, a coiled-coil domain, and an ATP/GTP-binding motif. Additionally we are shipping SNCAIP Proteins (6) and SNCAIP Kits (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SNCAIP 9627 Q9Y6H5
SNCAIP 307309  
SNCAIP 67847  
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Top anti-SNCAIP Antibodies at antibodies-online.com

Showing 10 out of 78 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Human Rabbit Un-conjugated EIA, WB The anti-Synphilin-1 C-term Pab is used in Western blot to detect Synphilin-1 in mouse brain lysate. 0.4 mL 6 to 8 Days
$484.00
Details
Human Rabbit Un-conjugated IHC, WB Immunohistochemical analysis of Synphilin 1 staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Western blot analysis of Synphilin 1 expression in HeLa (A), U2OS (B) whole cell lysates. 200 μL 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated ELISA, IHC, WB 100 μL Available
$363.46
Details
Human Rabbit Un-conjugated ELISA, IHC, WB Western blot analysis Synphilin-1 using LOVO whole cell lysates ABIN6278533 at 1/100 staining Mouse spleen tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22¡ãC. An HRP conjugated goat anti-rabbit antibody was used as the secondary 100 μL 11 to 12 Days
$390.77
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded rat brain labeled with Anti-Synphilin-1 Polyclonal Antibody, Unconjugated (ABIN736163) at 1:200 followed by conjugation to the secondary antibody and DAB staining. Rat brain lysates probed with Anti Synphilin-1 Polyclonal Antibody, Unconjugated (ABIN736163) at 1:200 in 4 °C. Followed by conjugation to secondary antibody at 1:3000 90min in 37 °C. Predicted band 100kD. Observed band size:60kD 100kD. 100 μL 3 to 7 Days
$317.90
Details
Human Rabbit Un-conjugated WB Western Blot at 1:1000 dilution Lane 1: human brain lysate Lane 2: U-87 MG whole cell lysate Lysates/proteins at 20 ug per lane. Antibody is used in Western blot to detect Synphilin-1 in mouse brain lysate. 400 μL 2 to 3 Days
$515.63
Details
Human Rabbit Alexa Fluor 488 IF (p)   100 μL 14 to 21 Days
$416.90
Details
Human Rabbit Alexa Fluor 555 IF (p)   100 μL 14 to 21 Days
$416.90
Details
Human Rabbit Alexa Fluor 350 IF (p)   100 μL 14 to 21 Days
$416.90
Details
Human Rabbit Alexa Fluor 647 IF (p)   100 μL 14 to 21 Days
$416.90
Details

Top referenced anti-SNCAIP Antibodies

  1. Human Polyclonal SNCAIP Primary Antibody for ELISA, WB - ABIN545419 : Nagano, Yamashita, Takahashi, Kishida, Nakamura, Iseki, Hattori, Mizuno, Kikuchi, Matsumoto: Siah-1 facilitates ubiquitination and degradation of synphilin-1. in The Journal of biological chemistry 2003 (PubMed)
    Show all 3 Pubmed References

  2. Human Polyclonal SNCAIP Primary Antibody for IF, IHC (p) - ABIN2476664 : Büttner, Delay, Franssens, Bammens, Ruli, Zaunschirm, de Oliveira, Outeiro, Madeo, Buée, Galas, Winderickx: Synphilin-1 enhances ?-synuclein aggregation in yeast and contributes to cellular stress and cell death in a Sir2-dependent manner. in PLoS ONE 2010 (PubMed)

More Antibodies against SNCAIP Interaction Partners

Human Synuclein, alpha Interacting Protein (SNCAIP) interaction partners

  1. results indicated that synphilin-1 may play neuroprotective roles in Parkinson Disease pathogenesis by inhibiting ROS production and apoptosis.

  2. Differential expression of synphilin-1 isoforms (and alpha-synuclein and parkin) was found in multiple system atrophy brains compared to control brain.

  3. Synphilin-1 binds ATP, but not CTP.

  4. Overexpression of human synphilin-1 in mice resulted in hyperphagia and obesity.

  5. Overexpression of SP1 in neurons, but not peripheral cells, increased the body weight of flies compared with that of non-transgenic controls. SP1 increased food intake but did not affect locomotor activity

  6. Although serine-129 phosphorylation of alpha-synuclein facilitates tubulin polymerization promoting protein (TPPP)-mediated alpha-SYN oligomerization, this modification does not seem to play an inevitable role in the early step of alpha-SYN oligomer formation.

  7. Mutation screening of SNCAIP identifies novel sequence variants using a bioinformatic approach; further studies are necessary to determine their possible functional consequences in South African patients with Parkinson's disease.

  8. Neuronal survival factor MEF2D is decreased in human and experimental Parkinson's disease, a decrease that is specifically associated with alpha-synuclein accumulation and aggregation.

  9. Synphilin-1 inhibits alpha-synuclein degradation by the proteasome.

  10. Knockdown of Herp gene unexpectedly facilitated the degradation of synphilin-1, and improved cell viability during proteasomal inhibition.

  11. Data show that periphilin displays an overlapping expression pattern with synphilin-1 in cellular and animal models and in Lewy bodies of Parkinson's disease (PD) patients, and support involvement of periphilin in PD.

  12. expression of synphilin-1 shortens N1E-115 cell division doubling time, promotes neurite outgrowth, and protects against Rotenone-induced toxicity; synphilin-1 displays a neurotrophic effect in vitro, may play a neuroprotective role in Parkinson's disease

  13. alpha-synuclein-synphilin-1 interaction significantly promotes the formation of cytoplasmic alpha-synuclein inclusions, which may have implications for Lewy body formation in neural cells

  14. The amino acid sequence of synphilin-1 shows extensive homology with its human counterpart, especially in regions containing ankyrin-like motifs and the coiled-coil domain. Expression of mouse synphilin-1 in tissues is similar to its human counterpart.

  15. results suggest that synphilin-1 has an important role in the formation of aggregates and cytotoxicity in Parkinson disease and that Dorfin may be involved in the pathogenic process by ubiquitylation of synphilin-1

  16. a causative role of the R621C mutation in the synphilin-1 gene in Parkinson's disease

  17. Changes in synuclein expression presage neurodegeneration in a Drosophila model of Parkinson disease.

  18. Siah-1 was found to abrogate the inhibitory effects of synphilin-1 on dopamine release

  19. role of aggresomes in cell viability was addressed in the context of over-expressing alpha-synuclein and its interacting partner synphilin-1

  20. Casein kinase II (CKII) phosphorylates synphilin-1; beta subunit of this enzyme complex binds to synphilin-1. CKII-mediated phosphorylation of synphilin-1, rather than alpha-synuclein, modulates the aggregation into inclusion bodies.

Mouse (Murine) Synuclein, alpha Interacting Protein (SNCAIP) interaction partners

  1. This study showed that A53T-alpha-synuclein overexpression in murine locus coeruleus induces Parkinson's disease-like pathology in neurons and glia.

  2. The finding of increased spine pathology in Thy1-E57K is a new pathogenic function of oligomeric a-syn and precedes overt neurodegeneration. Thus, it may constitute a readout for therapeutic approache.

  3. Mulberry fruit extract had inhibitory effects on the up-regulation of both alpha-synuclein and ubiquitin, the major components of lewy bodies, in substantia nigra and striatum in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine/probenecid model of early Parkinson's disease .

  4. Enhanced aggregation and phosphorylation of alphaSyn causes the loss of dopaminergic neurons leading to the decline of motor coordination.

  5. 2,3,7,8-tetrachlorodibenzo-p-dioxin promoted synphilin-1 degradation in an aryl hydrocarbon receptor-dependent way.

  6. These results suggest that alpha-syn might participate in mechanisms of vulnerability of selected neuronal populations in AD and that reducing alpha-syn might be a potential approach to protecting these populations from the toxic effects of amyloid beta.

  7. Neurons of A53T-alpha-Syn transgenic mice are more fragile to DNA damages.

  8. This study shows that alpha-synuclein is present in cerebellar glutamatergic terminals.

  9. These results suggest that increased levels of NUB1 play a potential role in degradation of detergent-insoluble alpha-synuclein in vivo, although it is insufficient to degrade abnormal alpha-synuclein in Lewy body disease model mice.

  10. SP1 results in a CCK response deficiency that may contribute to the increased meal size and overall hyperphagia in synphillin-1 transgenic mice

  11. TEM analysis of protein:inhibitor assays demonstrated that scyllo-inositol inhibits the aggregation of alpha-synuclein, suggesting the therapeutic potential of the small molecule in PD.

  12. We exploited atomic force microscopy (AFM) for the selective, nanoscale confinement of alpha-Synuclein on gold to study the early stages of alpha-Synuclein aggregation and the effect of small molecules, like dopamine, on the aggregation process.

  13. an important role of aSyn H50 in the pathogenesis of both sporadic and monogenic Parkinson's disease

  14. Sncaip physically interacts with PPP1 and affects PPP1 sorting to subcellular compartments.

  15. Studies identify a novel function of synphilin-1 in controlling food intake and body weight, and may provide a unique obesity model for future studies of obesity pathogenesis and therapeutics.

  16. Synphilin-1 can diminish the severity of alpha-synucleinopathy and play a neuroprotective role against A53T alpha-synuclein toxicity in vivo.

  17. synphilin-1 has a role in skill learning and motor performance

  18. expression of synphilin-1 shortens N1E-115 cell division doubling time, promotes neurite outgrowth, and protects against Rotenone-induced toxicity; synphilin-1 displays a neurotrophic effect in vitro, may play a neuroprotective role in Parkinson's disease

SNCAIP Antigen Profile

Protein Summary

This gene encodes a protein containing several protein-protein interaction domains, including ankyrin-like repeats, a coiled-coil domain, and an ATP/GTP-binding motif. The encoded protein interacts with alpha-synuclein in neuronal tissue and may play a role in the formation of cytoplasmic inclusions and neurodegeneration. A mutation in this gene has been associated with Parkinson's disease. Alternatively spliced transcript variants encoding different isoforms of this gene have been described, but the full-length nature of only two have been determined.

Gene names and symbols associated with SNCAIP

  • synuclein alpha interacting protein (SNCAIP) antibody
  • synuclein alpha interacting protein (sncaip) antibody
  • synuclein, alpha interacting protein (Sncaip) antibody
  • synuclein alpha interacting protein (Sncaip) antibody
  • synuclein, alpha interacting protein (synphilin) (Sncaip) antibody
  • 2810407O15Rik antibody
  • 4933427B05Rik antibody
  • BB104594 antibody
  • LOC100221074 antibody
  • MGC88953 antibody
  • SNCAIP antibody
  • Sph1 antibody
  • Syph1 antibody

Protein level used designations for SNCAIP

synuclein, alpha interacting protein , synuclein, alpha interacting protein (synphilin) , synphilin-1-like , alpha-synuclein-interacting protein , synphilin-1 , synuclein alpha interacting protein , synphilin-1 variant 1e

GENE ID SPECIES
100063985 Equus caballus
448237 Xenopus (Silurana) tropicalis
700372 Macaca mulatta
462021 Pan troglodytes
100406168 Callithrix jacchus
100481199 Ailuropoda melanoleuca
100559476 Anolis carolinensis
100221074 Taeniopygia guttata
9627 Homo sapiens
307309 Rattus norvegicus
426796 Gallus gallus
100720184 Cavia porcellus
67847 Mus musculus
481479 Canis lupus familiaris
100049698 Sus scrofa
540156 Bos taurus
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