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TAF7L is similar to a mouse gene that encodes a TATA box binding protein-associated factor, and shows testis-specific expression. Additionally we are shipping TAF7-Like RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 50kDa Antibodies (42) and many more products for this protein.
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Suggest that TAF7L plays an integral role in adipocyte gene expression by targeting enhancers as a cofactor for PPARgamma (show PPARG Proteins) and promoters as a component of the core transcriptional machinery.
the presence of the tissue-specific TAF7L subunit in TFIID functions to promote long-range chromatin interactions during brown adipose tissue lineage specification
TAF7L associates with TRF2 (show TERF2 Proteins) both in vitro and in testis, suggesting that TAF7L likely cooperates directly with TRF2 (show TERF2 Proteins) at promoters of a subset of postmeiotic genes to regulate spermiogenesis.
TAF7L replaces TAF7 (show TAF7 Proteins) as a TFIID subunit (show TAF6 Proteins) in late pachytene spermatocytes and in haploid cells.
Disruption of Taf7l causes reduced testis weight, decreased sperm production and motility, and abnormal morphology
Over-expression of TAF7L was observed in breast tumor cell lines.
Frameshift mutations of TAF7L gene is associated with stomach and colorectal cancers.
expression of AURKC (show AURKC Proteins), OIP5 (show OIP5 Proteins), PIWIL2 and TAF7L differed between patients with Acute myeloid leukemia (show BCL11A Proteins), myelodysplastic syndrome and healthy controls in a gender-dependent manner
TAF7L gene polymorphisms were found in male infertility patients and normal controls.
The sequence variant in exon 13 of the TAF7L gene located on the X chromosome may represent a risk factor for spermatogenic failure.
This gene is similar to a mouse gene that encodes a TATA box binding protein-associated factor, and shows testis-specific expression. The encoded protein could be a spermatogenesis-specific component of the DNA-binding general transcription factor complex TFIID. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
TATA box binding protein (TBP)-associated factor, RNA polymerase II, Q
, TATA box binding protein-associated factor RNA polymerase II subunit Q
, TATA box-binding protein-associated factor 50 kDa
, transcription initiation factor TFIID 50 kDa subunit
, transcription initiation factor TFIID subunit 7-like
, RNA polymerase II TBP-associated factor subunit Q
, TBP-associated factor, RNA polymerase II, Q
, cancer/testis antigen 40