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Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. Additionally we are shipping TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase I, B, 63kDa Antibodies (32) and and many more products for this protein.
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AEP (show LGMN Proteins) coactivator complex facilitates the initiation of RNAP2-dependent transcription via SL1 (show MMP3 Proteins) activity by loading TBP (show TBP Proteins) onto the TATA element.
hCdc14B (show CDC14B Proteins) promotes reactivation of rDNA transcription by dephosphorylating TAFI110 (show TAF1C Proteins). SIRT1 (show SIRT1 Proteins) becomes transiently enriched in nucleoli at the onset of mitosis. SIRT1 (show SIRT1 Proteins) deacetylates TAFI68 destabilizing SL1 (show MMP3 Proteins) binding to the rDNA promoter
findings show that Rrn7, a subunit of the yeast Pol I core factor, and its human ortholog TAF1B are TFIIB (show GTF2B Proteins)-like factors
TAF1B, a subunit of SL1 (show MMP3 Proteins), is structurally related to TFIIB/TFIIB (show GTF2B Proteins)-like proteins; SL1 (show MMP3 Proteins), essential for Pol I recruitment to rRNA gene promoter, also has an essential postpolymerase recruitment role, operating through TAF1B
Identification of MARCKS (show MARCKS Proteins), FLJ11383 and TAF1B as putative novel target genes in colorectal carcinomas with microsatellite instability.
The four most frequently mutated genes in colorectal cancers with microsatellite instability were ACVR2 (show ACVR2A Proteins) (92%), TAF1B (84%), ASTE1/HT001 (show ASTE1 Proteins) (80%) and TGFBR2 (show TGFBR2 Proteins) (77%).
Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes one of the SL1-specific TAFs.
RNA polymerase I-specific TBP-associated factor 68 kDa
, TATA box-binding protein-associated factor 1B
, TATA box-binding protein-associated factor RNA polymerase I subunit B
, TBP-associated factor 1B
, TBP-associated factor RNA polymerase I 68
, transcription factor TAFI68
, transcription initiation factor SL1/TIF-IB subunit B
, RNA polymerase I-specific TBP-associated factor 63 kDa
, SL1, 63kD subunit