TIA1 Cytotoxic Granule-Associated RNA Binding Protein Proteins (TIA1)

The product encoded by TIA1 is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. Additionally we are shipping TIA1 Antibodies (158) and and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TIA1 21841 P52912
TIA1 7072 P31483
TIA1 312510  
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Top TIA1 Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,749.58
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Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,749.58
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 11 Days
$888.80
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Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
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Escherichia coli (E. coli) Human Un-conjugated   5 applications Log in to see 1 to 2 Days
$318.85
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TIA1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,

Human , , ,
, ,
Rat (Rattus)

More Proteins for TIA1 Cytotoxic Granule-Associated RNA Binding Protein (TIA1) Interaction Partners

Mouse (Murine) TIA1 Cytotoxic Granule-Associated RNA Binding Protein (TIA1) interaction partners

  1. Results demonstrate that neither the basal nor seizure-induced expression profiles of COX-2 were altered in mice lacking a functional TIA-1 gene suggesting that TIA-1 does not contribute to regulation of COX-2 protein expression in neurons. Induced seizure threshold was also unchanged in mice lacking TIA-1 protein, indicating that this RNA binding protein does not influence the innate seizure threshold.

  2. Tia1 controls p53 mRNA translation in B cells.

  3. TIA1 knockdown or knockout inhibits tau misfolding and associated toxicity in cultured hippocampal neurons, while overexpressing TIA1 induces tau misfolding and stimulates neurodegeneration.

  4. This study showed that reactive oxygen species such as H2O2 oxidize the cytoplasmic stress granules (SG)-nucleating protein TIA1, thereby inhibiting SG assembly.

  5. Genetic ablation of the stress granule nucleator TIA-1 has a novel major effect on mRNAs encoding lipid homeostasis factors in the brain, similar to the fasting effect.

  6. TIA proteins can function as long-term regulators of the ACTB mRNA metabolism in mouse and human cells.

  7. TIA-1 binds tick-borne encephalitis virus RNA and is recruited to perinuclear sites of viral replication to inhibit viral translation.

  8. Either TIA1 or TIAR inactivation broadly alter normal development-associated signalling pathways in murine embryonic fibroblasts.

  9. TIA-1 as a negative regulator of allergen-mediated pulmonary inflammation in vivo.

  10. Data suggest that TIA-1 functions as a translational silencer of cyclooxygenase-2 (COX-2) expression and support the hypothesis that dysregulated RNA-binding of TIA-1 promotes COX-2 expression in neoplasia.

  11. TIA-1 and TTP are genetic modifiers of inflammatory arthritis that can alter the spectrum of cells that produce arthritogenic cytokines

  12. TIAR regulates the relative expression of TIA-1 isoforms.

  13. TIA-1-induced polysome disassembly is required for enhanced mRNA decay

  14. The TIA-1 beta-loop is involved in and is necessary and sufficient for RNA-binding activity of the TIA-1 second RNA recognition motif (RRM2), together with the beta-sheet surface.

  15. TIA1 and TIAL1 regulate the alternate splicing of lysyl hydroxylase 2

  16. The intronic splicing enhancer of minute virus of mice binds the cellular RNA-processing proteins TIA-1 and TIAR, which enhance usage of the nonconsensus donor.

Human TIA1 Cytotoxic Granule-Associated RNA Binding Protein (TIA1) interaction partners

  1. These findings suggest that Zn(2+) is a physiological ligand of TIA-1, acting as a stress-inducible second messenger to promote multimerization of TIA-1 and subsequent localization into stress granules.

  2. The repression of TIA-1 by miR-487a promoted cell proliferation and suppressed cell apoptosis in vitro, and the knockdown of miR-487a had the opposite effects.

  3. TIA1 mutation is an uncommon genetic cause for ALS in the Chinese population.

  4. TIA1 LCD mutations are not common in Chinese ALS/ALS-FTD

  5. TIA1 is a novel causative gene of amyotrophic lateral sclerosis.

  6. The purpose of this report is to provide a detailed description of the clinical and neuropathological features associated with the recently identified TIA1 mutations that cause ALS +/- FTD.

  7. TIA-1 knockdown by siRNA mimicked the effect of SAHA on COX-2 expression. These findings suggest SAHA can prevent TGF-beta1-induced COX-2 repression in lung fibroblasts post-transcriptionally through a novel TIA-1-dependent mechanism and provide new insights into the mechanisms underlying its potential antifibrotic activity

  8. expressions of TIA-1 and MFF were augmented in the cancerous liver tissues compared to the corresponding non-tumor tissues at mRNA and protein level, while the levels of miR-200a-3p and miR-27a/b were relatively lower in the cancerous liver tissues

  9. YAP (Yes-associated protein) expression negatively regulates TIA1 (Rox8 ortholog) expression and cell invasion in human cancer cells.

  10. Downregulation of TIA-1-enhanced mitochondrial elongation, whereas ectopic expression of TIA-1 resulted in mitochondria fragmentation. In addition, TIA-1 increased mitochondrial activity, including the rate of ATP synthesis and oxygen consumption.

  11. findings uncover a novel oncogenic function of TIA1 in esophageal tumorigenesis

  12. studied a novel Amyotrophic Lateral Sclerosis/Frontotemporal Dementia (ALS/FTD) family and identified the P362L mutation in the low-complexity domain (LCD) of TIA1; genetic association analyses showed an increased burden of TIA1 LCD mutations in ALS patients compared to controls; TIA1 mutations significantly increased the propensity of TIA1 protein to undergo phase transition

  13. Here we designed UC-rich and CU-rich 10-nt sequences for engagement of both RRM2 and RRM3 and demonstrated that the TIA-1 RRM23 construct preferentially binds the UC-rich RNA ligand. Together our data support a specific mode of TIA-1 RRM23 interaction with target oligonucleotides consistent with the role of TIA-1 in binding RNA to regulate gene expression

  14. miR-19a could promote cell proliferation and migration in CRC cells and accelerated tumor growth in xenograft mice by targeting TIA1.

  15. Data suggest that TPD52 (tumor protein D52) and a TPD52 fragment (residues 78-280) along with TIA-1 (T-cell intracellular antigen-1) and TIAR (TIA-1-related protein) contribute to mRNA stability as cis-acting and trans-acting factors; 3prime-untranslated regions of TPD52, TPD53, and TPD54 regulate expression of their respective genes in a post-transcriptional manner by altering mRNA stability.

  16. The results provide a mechanism for exon 16 3' splice site activation in which a coordinated effort among TIA1, Pcbp1, and RBM39 stabilizes or increases U2 snRNP recruitment, enhances spliceosome A complex formation, and facilitates exon definition through RBM39-mediated splicing regulation.

  17. AT1R mRNA is regulated by TIA-1 in a ER stress-dependent manner.

  18. This study showed that reactive oxygen species such as H2O2 oxidize the cytoplasmic stress granules (SG)-nucleating protein TIA1, thereby inhibiting SG assembly.

  19. TIA proteins play a role in the regulation and/or modulation of cellular homeostasis related to focal/cell adhesion, extracellular matrix and membrane and cytoskeleton dynamics.

  20. SERPINE1 mRNA dissociates from the translational repressor proteins Ago2 and TIA-1 upon platelet activation

TIA1 Protein Profile

Protein Summary

The product encoded by this gene is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15-kDa protein that is thought to be derived from the carboxyl terminus of the 40-kDa product by proteolytic processing. Alternative splicing resulting in different isoforms of this gene product has been described in the literature.

Gene names and symbols associated with TIA1

  • nucleolysin TIA-1 isoform p40 (PTRG_10065)
  • hypothetical protein (PGTG_08590)
  • nucleolysin TIAR (LOC5568274)
  • nucleolysin tia-1 (CpipJ_CPIJ013665)
  • nucleolysin TIA-1 (VDBG_07004)
  • nucleolysin TIA-1 (MGYG_03339)
  • nucleolysin TIA-1 (Tsp_15456)
  • cytotoxic granule-associated RNA binding protein 1 (tia1)
  • cytotoxic granule-associated RNA binding protein 1 (Tia1)
  • TIA1 cytotoxic granule associated RNA binding protein (TIA1)
  • TIA1 cytotoxic granule-associated RNA binding protein (Tia1)
  • TIA1 cytotoxic granule-associated RNA binding protein L homeolog (tia1.L)
  • 2310050N03Rik protein
  • AI256674 protein
  • mTIA-1 protein
  • tia-1 protein
  • tia1 protein
  • TIAL1 protein
  • TIAR protein
  • WDM protein

Protein level used designations for TIA1

nucleolysin TIA-1 isoform p40 , nucleolysin tia-1 , nucleolysin TIA-1 , TIA1 cytotoxic granule-associated RNA binding protein , Nucleolysin TIA-1 , RNA-binding protein TIA-1 , T-cell-restricted intracellular antigen-1 , cytotoxic granule-associated RNA-binding protein 1 , p40-TIA-1 (containing p15-TIA-1) , TIA1 cytotoxic granule-associated RNA binding protein-like 1 , nucleolysin TIAR , cytotoxic granule-associated RNA binding protein 1

GENE ID SPECIES
6348364 Pyrenophora tritici-repentis Pt-1C-BFP
10545120 Puccinia graminis f. sp. tritici CRL 75-36-700-3
5568274 Aedes aegypti
6046587 Culex quinquefasciatus
9527427 Verticillium alfalfae VaMs.102
10031129 Arthroderma gypseum CBS 118893
10897100 Trichinella spiralis
100196522 Salmo salar
21841 Mus musculus
7072 Homo sapiens
771327 Gallus gallus
538533 Bos taurus
312510 Rattus norvegicus
610625 Canis lupus familiaris
447385 Xenopus laevis
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