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TRAF4 encodes a member of the TNF receptor associated factor (TRAF) family. Additionally we are shipping TRAF4 Antibodies (78) and many more products for this protein.
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miR (show MLXIP Proteins)-4443 acts in a tumor-suppressive manner by down-regulating TRAF4 and NCOA1 (show NCOA1 Proteins) downstream of MEK (show MAP2K1 Proteins)-C/EBP (show CEBPA Proteins)-mediated leptin (show LEP Proteins) and insulin (show INS Proteins) signaling, and that insulin (show INS Proteins) and/or leptin (show LEP Proteins) resistance (e.g. in obesity) may suppress this pathway and increase the risk of metastatic CRC (show CALR Proteins).
TRAF4 expression is higher in mastocytosis patients with food hypersensitivity in their medical history, while B3GAT1 (show B3GAT1 Proteins) expression is lower in mastocytosis patients with insect venom allergy in history
Determined the crystal structure of TRAF (show TRAF1 Proteins) domain of TRAF4 (residues 292-466) at 2.60 A resolution by X-ray crystallography method. The trimericly assembled TRAF4 resembles a mushroom shape, containing a super helical "stalk" which is made of three right-handed intertwined alpha helixes and a C-terminal "cap", which is divided at residue L302 as a boundary.
TRAF4 may promote oral squamous carcinoma cell growth, invasion and migration by Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) pathway.
There was a significant positive correlation between TRAF2 (show TRAF2 Proteins) and TRAF4 expression levels in malignant pleural effusion cells
The TRAF4-ERK (show IL17A Proteins)5 is a dominant pathway in human skin squamous cell carcinoma.
Data showed that TRAF4 was highly expressed in non-small cell lung cancer (NSCLC) cells, and miR (show MLXIP Proteins)-370 overexpression significantly inhibited its expression. These results suggest that TRAF4 serves as an oncogene (show RAB1A Proteins) in NSCLC.
these results suggest that TRAF4 promoted colon cancer cell growth and invasion
Expression of tumor necrosis factor receptor-assicated factor 4 correlates with expression of Girdin and promotes nuclear translocation of Girdin in breast cancer
p70s6k (show RPS6KB1 Proteins)/S6 signaling pathway played an important role in the promoting function of TRAF4 on cell proliferation. This work suggests a new direction for understanding the oncogenic function of TRAF4 in breast cancer.
A novel IL-17 (show IL17A Proteins) signaling pathway controlling keratinocyte proliferation and tumorigenesis via the TRAF4-ERK5 (show MAPK7 Proteins) axis.
Data indicate that TNF receptor associated factor 4 (TRAF4) recruited the E3-ligase SMURF2 (show SMURF2 Proteins), to degrade the IL-25R-inhibitory molecule DAZ associated protein 2 (DAZAP2 (show DAZAP2 Proteins)).
Like IKKalpha (show CHUK Proteins), TRAF4 is atypical within its family because it is the only TRAF (show TRAF1 Proteins) family member to negatively regulate innate immune signaling. IKKalpha's phosphorylation of serine-426 on TRAF4 was required for this negative regulation.
Report divergent effects of p47(phox) phosphorylation at S303-4 or S379 on tumor necrosis factor-alpha (show TNF Proteins) signaling via TRAF4 and MAPK (show MAPK1 Proteins) in endothelial cells.
These results provide conclusive evidence for the pivotal contribution of TRAF4 to myelination.
enhances TNF-alpha (show TNF Proteins) translation
A novel motif in the Crohn's disease susceptibility protein, NOD2, allows TRAF4 to down-regulate innate immune responses.
Impaired neural tube closure, axial skeleton malformations, and tracheal ring disruption in TRAF4-deficient mice.
TRAF4 may play a role in p53 (show TP53 Proteins)-mediated proapoptotic signaling in the response to cellular stress
MEKK4 (show MAP3K4 Proteins) is the MAPK (show MAPK1 Proteins) kinase kinase for TRAF4 regulation of the JNK (show MAPK8 Proteins) pathway
cloning of two zebrafish orthologs of the human traf4, traf4a and traf4b; during embryogenesis, traf4b expression is present in a weak ubiquitous manner
This gene encodes a member of the TNF receptor associated factor (TRAF) family. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. The encoded protein has been shown to interact with neurotrophin receptor, p75 (NTR/NTSR1), and negatively regulate NTR induced cell death and NF-kappa B activation. This protein has been found to bind to p47phox, a cytosolic regulatory factor included in a multi-protein complex known as NAD(P)H oxidase. This protein thus, is thought to be involved in the oxidative activation of MAPK8/JNK. Alternatively spliced transcript variants have been observed but the full-length nature of only one has been determined.
, RING finger protein 83
, cysteine-rich domain associated with RING and Traf domains protein 1
, cysteine-rich domain associated with ring and TRAF domain
, malignant 62
, metastatic lymph node gene 62 protein
, tumor necrosis receptor-associated factor 4A
, TNF receptor-associated factor 4
, cysteine-rich motif associated to RING and Traf domains protein 1
, LOW QUALITY PROTEIN: TNF receptor-associated factor 4