TNF Receptor-Associated Factor 4 Proteins (TRAF4)

TRAF4 encodes a member of the TNF receptor associated factor (TRAF) family. Additionally we are shipping TRAF4 Antibodies (78) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TRAF4 9618 Q9BUZ4
TRAF4 22032 Q61382
Rat TRAF4 TRAF4 303285  
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Top TRAF4 Proteins at

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 15 to 18 Days
Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 11 to 18 Days

TRAF4 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
Mouse (Murine)

More Proteins for TNF Receptor-Associated Factor 4 (TRAF4) Interaction Partners

Human TNF Receptor-Associated Factor 4 (TRAF4) interaction partners

  1. miR (show MLXIP Proteins)-4443 acts in a tumor-suppressive manner by down-regulating TRAF4 and NCOA1 (show NCOA1 Proteins) downstream of MEK (show MAP2K1 Proteins)-C/EBP (show CEBPA Proteins)-mediated leptin (show LEP Proteins) and insulin (show INS Proteins) signaling, and that insulin (show INS Proteins) and/or leptin (show LEP Proteins) resistance (e.g. in obesity) may suppress this pathway and increase the risk of metastatic CRC (show CALR Proteins).

  2. TRAF4 expression is higher in mastocytosis patients with food hypersensitivity in their medical history, while B3GAT1 (show B3GAT1 Proteins) expression is lower in mastocytosis patients with insect venom allergy in history

  3. Determined the crystal structure of TRAF (show TRAF1 Proteins) domain of TRAF4 (residues 292-466) at 2.60 A resolution by X-ray crystallography method. The trimericly assembled TRAF4 resembles a mushroom shape, containing a super helical "stalk" which is made of three right-handed intertwined alpha helixes and a C-terminal "cap", which is divided at residue L302 as a boundary.

  4. TRAF4 may promote oral squamous carcinoma cell growth, invasion and migration by Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) pathway.

  5. There was a significant positive correlation between TRAF2 (show TRAF2 Proteins) and TRAF4 expression levels in malignant pleural effusion cells

  6. The TRAF4-ERK (show IL17A Proteins)5 is a dominant pathway in human skin squamous cell carcinoma.

  7. Data showed that TRAF4 was highly expressed in non-small cell lung cancer (NSCLC) cells, and miR (show MLXIP Proteins)-370 overexpression significantly inhibited its expression. These results suggest that TRAF4 serves as an oncogene (show RAB1A Proteins) in NSCLC.

  8. these results suggest that TRAF4 promoted colon cancer cell growth and invasion

  9. Expression of tumor necrosis factor receptor-assicated factor 4 correlates with expression of Girdin and promotes nuclear translocation of Girdin in breast cancer

  10. p70s6k (show RPS6KB1 Proteins)/S6 signaling pathway played an important role in the promoting function of TRAF4 on cell proliferation. This work suggests a new direction for understanding the oncogenic function of TRAF4 in breast cancer.

Mouse (Murine) TNF Receptor-Associated Factor 4 (TRAF4) interaction partners

  1. A novel IL-17 (show IL17A Proteins) signaling pathway controlling keratinocyte proliferation and tumorigenesis via the TRAF4-ERK5 (show MAPK7 Proteins) axis.

  2. Data indicate that TNF receptor associated factor 4 (TRAF4) recruited the E3-ligase SMURF2 (show SMURF2 Proteins), to degrade the IL-25R-inhibitory molecule DAZ associated protein 2 (DAZAP2 (show DAZAP2 Proteins)).

  3. Like IKKalpha (show CHUK Proteins), TRAF4 is atypical within its family because it is the only TRAF (show TRAF1 Proteins) family member to negatively regulate innate immune signaling. IKKalpha's phosphorylation of serine-426 on TRAF4 was required for this negative regulation.

  4. Report divergent effects of p47(phox) phosphorylation at S303-4 or S379 on tumor necrosis factor-alpha (show TNF Proteins) signaling via TRAF4 and MAPK (show MAPK1 Proteins) in endothelial cells.

  5. These results provide conclusive evidence for the pivotal contribution of TRAF4 to myelination.

  6. enhances TNF-alpha (show TNF Proteins) translation

  7. A novel motif in the Crohn's disease susceptibility protein, NOD2, allows TRAF4 to down-regulate innate immune responses.

  8. Impaired neural tube closure, axial skeleton malformations, and tracheal ring disruption in TRAF4-deficient mice.

  9. TRAF4 may play a role in p53 (show TP53 Proteins)-mediated proapoptotic signaling in the response to cellular stress

  10. MEKK4 (show MAP3K4 Proteins) is the MAPK (show MAPK1 Proteins) kinase kinase for TRAF4 regulation of the JNK (show MAPK8 Proteins) pathway

Zebrafish TNF Receptor-Associated Factor 4 (TRAF4) interaction partners

  1. cloning of two zebrafish orthologs of the human traf4, traf4a and traf4b; during embryogenesis, traf4b expression is present in a weak ubiquitous manner

TRAF4 Protein Profile

Protein Summary

This gene encodes a member of the TNF receptor associated factor (TRAF) family. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. The encoded protein has been shown to interact with neurotrophin receptor, p75 (NTR/NTSR1), and negatively regulate NTR induced cell death and NF-kappa B activation. This protein has been found to bind to p47phox, a cytosolic regulatory factor included in a multi-protein complex known as NAD(P)H oxidase. This protein thus, is thought to be involved in the oxidative activation of MAPK8/JNK. Alternatively spliced transcript variants have been observed but the full-length nature of only one has been determined.

Gene names and symbols associated with TRAF4

  • TNF receptor associated factor 4 (TRAF4)
  • TNF receptor associated factor 4 (Traf4)
  • Tnf receptor associated factor 4 (Traf4)
  • tnf receptor-associated factor 4b (traf4b)
  • TNF receptor associated factor 4 L homeolog (traf4.L)
  • A530032M13Rik protein
  • cart1 protein
  • mln62 protein
  • msp2 protein
  • rnf83 protein
  • traf-4 protein
  • traf4 protein

Protein level used designations for TRAF4

MLN 62 , RING finger protein 83 , cysteine-rich domain associated with RING and Traf domains protein 1 , cysteine-rich domain associated with ring and TRAF domain , malignant 62 , metastatic lymph node gene 62 protein , tumor necrosis receptor-associated factor 4A , TNF receptor-associated factor 4 , cysteine-rich motif associated to RING and Traf domains protein 1 , LOW QUALITY PROTEIN: TNF receptor-associated factor 4

9618 Homo sapiens
22032 Mus musculus
303285 Rattus norvegicus
404035 Danio rerio
447325 Xenopus laevis
100688511 Canis lupus familiaris
781568 Bos taurus
100723177 Cavia porcellus
100518396 Sus scrofa
100072085 Equus caballus
101107451 Ovis aries
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