TYRO Protein tyrosine Kinase Binding Protein (TYROBP) ELISA Kits

Zebrafish TYRO Protein tyrosine Kinase Binding Protein (TYROBP) interaction partners

1. The structure of the adaptor protein dap12 has been identified in the zebrafish genome.

2. DAP12-based activating pathway is conserved between bony fish and mammals

Human TYRO Protein tyrosine Kinase Binding Protein (TYROBP) interaction partners

1. Heterozygous carriership of the TYROBP deletion is not a major risk factor of cognitive impairment.

2. Mutations in TYROBP are not a common cause of dementia in this Turkish cohort.

3. Rare TYROBP variants might contribute to early-onset Alzheimer's disease risk by reduction of TREM2 expression, a well-established risk factor for AD.

4. TYROBP influences a batch of genes that are related to Alzheimer's disease; ZNF329 and RB1 significantly regulate those 'mesenchymal' gene expression signature genes for brain tumors. By merely leveraging gene expression data, Context Based Dependency Network (CBDN) can efficiently infer the existence of gene-gene interactions as well as their regulatory directions.

5. TYROBP/CSTA gene interaction might play pivotal roles in the occurrence and development of Postmenopausal Osteoporosis

6. The different expression of DAP12 compared to TREM2 represents the first description of such variable expressivity in Nasu-Hakola disease (NHD) microglia.

7. the microglial membrane adaptor protein DAP12 was required for both nerve injury- and intrathecal CSF1-induced upregulation of pain-related microglial genes and the ensuing pain, but not for microglial proliferation

8. Impaired signaling by the TREM2-DAP12 pathway leads to altered immune responses in phagocytosis, cytokine production, and microglial proliferation and survival, thus contributing to disease pathogenesis. Review.

9. T cells modified to express a KIR-CAR and DAP12 exhibit superior antitumor activity compared with standard first- and second-generation CD3zeta-based CARs in a xenograft model of mesothelioma highly resistant to immunotherapy.

10. This study reveled that TYROBP having a central role in the bipolar disease and schizophrenia manifestation.

11. isolated PMNs have an increased proportion of both TREM1 and DAP12 compared to normal healthy control

12. results support a role of DAP12 in stabilizing TREM2-CTF, thereby protecting against excessive pro-inflammatory responses.

13. Its mutation is a known genetic cause of Nasu-Hakola disease.

14. Data indicate that NKG2 receptor NKG2E was capable of associating with CD94 and DAP12 but that the complex was retained intracellularly at the endoplasmic reticulum.

15. Macrophage traits in BRC cells facilitate the metastatic process and DAP12 expression might promote metastatic homing to bone and liver tissues.

16. DAP12 has a role in trafficking newly synthesized KIR to the cell surface. It interacts with an immature KIR2DS isoform likely initiating in the ER. DAP12also impacts KIR2DS surface stability.

17. dynamics and dimerization of the TM helix of DAP12 in the membrane bilayer

18. A molecular defect of DAP12 in human monocytes deregulates the gene network pivotal for maintenance of myeloid cell function in Nasu-Hakola disease.

19. the putative periodontal pathogen P. gingivalis can positively regulate the expression of the TREM-1/DAP12 pathway in monocytic cells.

20. DAP12 gene levels were not increased in the monocytes of schizophrenic, bioplar or major depressive disorder patients.

Mouse (Murine) TYRO Protein tyrosine Kinase Binding Protein (TYROBP) interaction partners

1. Data (including data from studies conducted with cells from knockout mice) suggest that Cd300e on the surface of monocytes or mast cells recognizes the ligand sphingomyelin and thereby regulates non-classical and intermediate immunologic functions through FcRgamma and DAP12. (Cd300e = CD300 antigen like family member E; FcRgamma = Fc receptor subunit gamma; DAP12 = DNAX-activation protein-12)

2. We identified modulatory effects of TYROBP deficiency on the level of phosphorylation of TAU that was accompanied by a reduction in the severity of neuritic dystrophy. TYROBP deficiency also altered the expression of several AD related genes, including Cd33. Electrophysiological abnormalities and learning behavior deficits associated with APP/PSEN1 transgenes were greatly attenuated on a Tyrobp-null background.

3. These results demonstrate that PTX targets the innate immunity through DAP12, FcRgamma, and MyD88 providing new insights into the immunobiology of PTX.

4. Recent studies have revealed that activated microglia in the spinal dorsal horn exacerbate neuropathic pain, which has suggested that suppression of microglial activity should be considered as a therapeutic target. However, only a few molecules have been identified as regulators of microglial activity. In this study, we focused on a receptor complex of TREM2 and DAP12, both of which are expressed by microglia and have bee

5. TNF/IL-6 generated osteoclasts in vitro that resorbed mineralized tissue through a pathway dependent on IL-6R, NFATc1, DNAX-activation protein 12, and cell proliferation.

6. The findings suggest that DAP12 acts as a brake on the pulmonary immune response to C. neoformans by promoting pulmonary eosinophilia and by inhibiting the activation and antifungal activities of effector cells, including NK cells and macrophages.

7. significant role of DAP12 in the initial inflammatory response, bone remodeling and regeneration

8. DAP12-mediated microglial activation following axotomy promotes pro-inflammatory responses, and thereby accelerates nerve injury-induced neuron death

9. results support a role of DAP12 in stabilizing TREM2-CTF, thereby protecting against excessive pro-inflammatory responses.

10. a previously unrecognized role for DAP12 expression in tissue-resident alveolar macrophages in mediating acute noninfectious tissue injury through regulation of neutrophil trafficking.

11. DAP12 expression in liver grafts regulates donor mDC migration to host lymphoid tissue, alloreactive T cell responses and transplant tolerance

12. Integrin alphav beta3/Dap12 double-deficient developed profound osteoporosis.

13. Our study identifies the DAP12/IRAK-M/IL-10 to be a novel molecular pathway in APCs exploited by mycobacterial pathogens, allowing infection a foothold in the lung.

14. We conclude that DAP12, partly through TREM1/3, is involved in renal inflammation during progression of unilateral ureter obstruction.

15. Siglec-15 regulates osteoclast development and bone resorption by modulating receptor activator of nuclear factor kappaB ligand (RANKL) signaling in association with DAP12.

16. Dap12- and FcRgamma-deficiency exacerbates Granulocyte-Macrophage Colony-Stimulating Factor-driven monocyte differentiation and production of inflammatory monocyte-derived dendritic cells.

17. The effects of DAP12 deficiency on development of autoimmune uveitis are dramatically affected by environmental factors.

18. DOK3 physically associated with the ITAM of DAP12 through its phosphotyrosine-binding domain. In response to LPS, DOK3 was phosphorylated in a DAP12- and Src-dependent manner, which led to translocation of phosphorylated DOK3 to the plasma membrane.

19. DAP12 is involved in microglia-induced dopaminergic neuron cell death in an in vitro model of Parkinson's disease.

20. the Siglec-15-DAP12-Syk-signaling cascade plays a critical role in functional osteoclast formation.

Cow (Bovine) TYRO Protein tyrosine Kinase Binding Protein (TYROBP) interaction partners

1. cloning, sequencing, and cell surface expression pattern