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TAS2R14 product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. Additionally we are shipping Taste Receptor, Type 2, Member 14 Antibodies (16) and many more products for this protein.
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Thus the beta2AR (show ADRB2 Proteins) acts as a double-edged sword: increasing TAS2R14 cell surface expression, but when activated by beta-agonist, partially offsetting the expression phenotype by direct receptor:receptor desensitization of TAS2R14 function.
These data indicate that, unlike in taste cells, TAS2Rs couple to the prevalent G proteins, Galphai1, Galphai2 (show GNAI2 Proteins), and Galphai3 (show GNAI3 Proteins), with no evidence for functional coupling to Galphagust.
Heterologously expressed T2R14 responds to multiple flavones. These flavones also activate T2R14-driven calcium signals in primary cells that activate nitric oxide production to increase ciliary beating and mucociliary clearance.
Probing the Binding Pocket of the Broadly Tuned Human Bitter Taste Receptor (show TAS2R7 Proteins) TAS2R14 by Chemical Modification of Cognate Agonists.
TAS2R14 and TAS2R39 were activated by isoflavones and other isoflavonoids.
no evidence of statistically significant associations between polymorphisms in the TAS2R14 gene and colon cancer risk
This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the taste receptor gene cluster on chromosome 12p13.
taste receptor, type 2, member 14
, candidate taste receptor mt2r56
, taste receptor type 2 member 116
, taste receptor, type 2, member 7
, taste receptor rT2R2
, taste receptor type 2 member 123
, taste receptor type 2 member 2
, taste receptor type 2 member 23
, taste receptor family B member 1
, taste receptor type 2 member 14
, taste receptor, family B, member 1