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validated two new TES cocomplex partners: TGFB1I1 and a short form of the glucocorticoid receptor. TES and TGFB1I1 are shown to oppositely affect cell spreading providing biological validity for their copresence in complexes since they act in similar processes
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these data indicate that TES functions as a necessary suppressor of colorectal cancer progression by activating p38-MAPK signaling pathways.
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testin region (amino acids 52-233) harbouring the PET domain interacts with the C-terminal LIM1-2 domains
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Testin plays an important role in the development and progression of non-small cell lung cancer. Testin is a tumor suppressor.
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VASP, zyxin and TES are tension-dependent members of focal adherens junctions independent of the alpha-catenin-vinculin module.
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we confirm that the TES promoter is unmethylated in normal adult and fetal tissues. Re-expression of TESTIN protein in acute lymphoblastic leukemia cells using expression plasmid transfection results in rapid cell death or cell cycle arrest.
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Loss of TES gene expression is associated with nasopharyngeal carcinoma.
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findings suggest that the TES gene is a novel tumor suppressor gene
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TESTIN was hypermethylated in 43.7% endometrial cancer tissues (p < 0.001). Moreover, TESTIN hypermethylation was significantly correlated with advanced tumor stage, deep myometrial invasion and lymphatic node metastasis.
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Downregulation of TES was associated with breast cancer.
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TESTIN was commonly downregulated in human endometrial carcinoma and was associated with poor prognostic markers.
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A further significant correlation was observed between TES downregulation and the luminal B subtype independent of survivin expression.
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TES, as a valuable marker of breast cancer prognosis, plays an important role in the development and progression of breast cancer. TES may be an effective novel target in breast cancer prevention and treatment.
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Low TES gene expression is associated with coronary artery disease.
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Alterations of TES mRNA level may predict the location of metastasis. CAV1 possibly affect the cancer cell invasion
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These results suggest an interplay between the CaR and testin in the regulation of CaR-mediated Rho signalling with possible effects on the cytoskeleton.
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Molecular recognition of the Tes LIM2-3 domains by the actin-related protein Arp7A.
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data implicate TES methylation in ALL and provide additional evidence for the involvement of LIM domain proteins in leukaemogenesis
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results support the role of TES as a TSG in gastric carcinogenesis and that TES is inactivated primarily by LOH and CpG island methylation
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The expression level of TES is significantly down-regulated in primary gastric cancer.
