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The protein encoded by this intronless gene is an endothelial-specific type I membrane receptor that binds thrombin. Additionally we are shipping Thrombomodulin Kits (99) and Thrombomodulin Proteins (25) and many more products for this protein.
Showing 10 out of 269 products:
Human Polyclonal Thrombomodulin Primary Antibody for WB - ABIN2801892
Suzuki, Kusumoto, Deyashiki, Nishioka, Maruyama, Zushi, Kawahara, Honda, Yamamoto, Horiguchi: Structure and expression of human thrombomodulin, a thrombin receptor on endothelium acting as a cofactor for protein C activation. in The EMBO journal 1987
Show all 5 Pubmed References
Mouse (Murine) Polyclonal Thrombomodulin Primary Antibody for CyTOF, FACS - ABIN4899312
Schmidt, Yang, Janssen, Gandjeva, Perez, Barthel, Zemans, Bowman, Koyanagi, Yunt, Smith, Cheng, Overdier, Thompson, Geraci, Douglas, Pearse, Tuder: The pulmonary endothelial glycocalyx regulates neutrophil adhesion and lung injury during experimental sepsis. in Nature medicine 2013
Show all 4 Pubmed References
Human Monoclonal Thrombomodulin Primary Antibody for FACS, WB - ABIN2192010
Dömötör, Benzakour, Griffin, Yule, Fukudome, Zlokovic: Activated protein C alters cytosolic calcium flux in human brain endothelium via binding to endothelial protein C receptor and activation of protease activated receptor-1. in Blood 2003
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Human Monoclonal Thrombomodulin Primary Antibody for WB - ABIN2192009
Tsuneyoshi, Fukudome, Higuchi, Kimoto: Preparation and characterization of monoclonal antibodies to thrombomodulin. in Hybridoma (2005) 2005
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Human Monoclonal Thrombomodulin Primary Antibody for IHC (fro), FACS - ABIN2478498
Drake, Loke: Isolation of endothelial cells from human first trimester decidua using immunomagnetic beads. in Human reproduction (Oxford, England) 1992
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Human Monoclonal Thrombomodulin Primary Antibody for FM, IHC (fro) - ABIN2688974
Teasdale, Bird, Bird: Internalization of the anticoagulant thrombomodulin is constitutive and does not require a signal in the cytoplasmic domain. in Immunology and cell biology 1995
Human Monoclonal Thrombomodulin Primary Antibody for FACS - ABIN4896077
Silk, Silk, Ichiryu, Davies, Nolan, Leishman, Carpenter, Watt, Cerundolo, Fairchild: Cross-presentation of tumour antigens by human induced pluripotent stem cell-derived CD141(+)XCR1+ dendritic cells. in Gene therapy 2012
Mouse (Murine) Monoclonal Thrombomodulin Primary Antibody for FACS - ABIN4895906
Geiger, Pawar, Kerschen, Nattamai, Hernandez, Liang, Fernández, Cancelas, Ryan, Kustikova, Schambach, Fu, Wang, Fink, Petersen, Zhou, Griffin, Baum, Weiler, Hauer-Jensen: Pharmacological targeting of the thrombomodulin-activated protein C pathway mitigates radiation toxicity. in Nature medicine 2012
Mouse (Murine) Monoclonal Thrombomodulin Primary Antibody for CyTOF, FACS - ABIN4899313
Belcher, Chen, Nguyen, Milbauer, Abdulla, Alayash, Smith, Nath, Hebbel, Vercellotti: Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease. in Blood 2014
Fibrinogen gamma acts as thrombomodulin II. (Review)
Thrombomodulin (TM) promotes angiogenesis by enhancing cell adhesion, migration, and FAK (show PTK2 Antibodies) activation through interaction with fibronectin (show FN1 Antibodies).
The elevation of serum thrombomodulin (sTM)level suggests that endothelial damage occurs in Abdominal Aortic Aneurysm pathogenesis.
This population-based cohort study within the ARIC study did not replicate the Hernandez et al. finding that carrying the minor allele of 3 THBD SNPs doubles the risk of venous thromboembolism in African Americans. In fact, the HRs of VTE among carriers of the minor allele were <1. HRs were similar for white subjects. A strand-flip did not explain the discrepancies.
these results suggest a novel function for thrombomodulin as an adhesion molecule in monocytes, where it enhances cell adhesion by binding Ley, leading to beta2 integrin activation via p38 MAPK
TM, especially TME45, maintains vascular integrity, at least in part, via Src (show SRC Antibodies) signaling.
The present study found that the fifth epidermal growth factor (show EGF Antibodies)-like domain of thrombomodulin (TME5) possesses the cytoprotective function in association with an increase in levels of anti-apoptotic myeloid cell leukemia-1 protein in an activated protein C (show PROC Antibodies)-independent
Case Report: CD141+ myeloid dentritic cell differentiation of a juvenile myelomonocytic leukemia.
The finding of a previously unrecognized fibrinolytic phenotype indicates that bleeding in Thrombomodulin-associated coagulopathy has a complex pathogenesis and highlights the pivotal role of TM as a regulator of hemostasis.
TM mediates cell proliferation and migration via the Epithelial-To-Mesenchymal Transition (EMT (show ITK Antibodies)) biomarkercyclooxygenase (COX)-2 (show COX2 Antibodies)
macrophage infiltration and neointima formation following arterial ligation-induced vascular injury were higher in wild-type than in myeloid-specific thrombomodulin-deficient mice
discovery of a novel physiological function of thrombomodulin-dependent activated protein C (show PROC Antibodies) generation within the CNS
the lectin-like domain of thrombomodulin is critically involved in host defence against E. coli induced acute pyelonephritis
Identified Nur77 (show NR4A1 Antibodies)/Nor1 (show NR4A3 Antibodies) as novel regulators of thrombomodulin expression and function in vascular endothelial cells.
TM expression in corneal epithelium was modulated during the corneal wound healing process, and may be regulated by PDGF (show PDGFA Antibodies)-BB. In addition, rTMD23 has therapeutic potential in corneal injury
Thrombomodulin contributes to gamma tocotrienol-mediated lethality protection and hematopoietic cell recovery in irradiated mice
the recombinant epidermal growth factor (show EGF Antibodies)-like domain plus serine/threonine-rich domain of thrombomodulin suppresses the inflammatory response in mice
Thrombomodulin may modulate allergic responses by inhibiting the activation of both eosinophils and mast cells.
Thrombomodulin modulates dendritic cells via both antagonism of high mobility group protein B1 (show HMGB1 Antibodies) and an independent mechanism.
Atorvastin induces THBD expression in the aorta of cholesterol-fed rabbits.
The protein encoded by this intronless gene is an endothelial-specific type I membrane receptor that binds thrombin. This binding results in the activation of protein C, which degrades clotting factors Va and VIIIa and reduces the amount of thrombin generated. Mutations in this gene are a cause of thromboembolic disease, also known as inherited thrombophilia.
, CD141 antigen
, snoRNA MBII-339