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The protein encoded by this intronless gene is an endothelial-specific type I membrane receptor that binds thrombin.
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Mouse (Murine) Thrombomodulin ELISA Kit for Sandwich ELISA - ABIN424235
Raeven, Salibasic, Drechsler, Weixelbaumer, Jafarmadar, van Griensven, Bahrami, Osuchowski: A non-lethal traumatic/hemorrhagic insult strongly modulates the compartment-specific PAI-1 response in the subsequent polymicrobial sepsis. in PLoS ONE 2013
Show all 6 Pubmed References
Human Thrombomodulin ELISA Kit for Sandwich ELISA - ABIN415045
Tsimaris, Deligeoroglou, Athanasopoulos, Economou, Stamatelopoulos, Rizos, Papamichael, Lambrinoudaki, Mastorakos, Creatsas: The effect of hormone therapy on biochemical and ultrasound parameters associated with atherosclerosis in 46,XY DSD individuals with female phenotype. in Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 2014
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Rat (Rattus) Thrombomodulin ELISA Kit for Sandwich ELISA - ABIN368176
Yamakawa, Matsumoto, Imamura, Muroya, Yamada, Nakagawa, Shimazaki, Ogura, Kuwagata, Shimazu: Electrical vagus nerve stimulation attenuates systemic inflammation and improves survival in a rat heatstroke model. in PLoS ONE 2013
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Human Thrombomodulin ELISA Kit for Sandwich ELISA - ABIN1445996
Akil, Zhang, Mumaw, Raiker, Yu, Velez de Mendizabal, Haneline, Robertson, Skiles, Diaz-Ricart, Carreras, Renbarger, Hanash, Bies, Paczesny: Biomarkers for Diagnosis and Prognosis of Sinusoidal Obstruction Syndrome after Hematopoietic Cell Transplantation. in Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2015
Rat (Rattus) Thrombomodulin ELISA Kit for Sandwich ELISA - ABIN416379
Kaija, Pakanen, Uusitalo, Nikkilä, Kortelainen, Porvari: Changes in cardiac thrombomodulin and heat shock transcription factor 1 expression and peripheral thrombomodulin and catecholamines during hypothermia in rats. in Stress (Amsterdam, Netherlands) 2014
Dog (Canine) Thrombomodulin ELISA Kit for Sandwich ELISA - ABIN416633
Kuleš, Gotić, Mrljak, Barić Rafaj: Blood markers of fibrinolysis and endothelial activation in canine babesiosis. in BMC veterinary research 2017
Taken together, our findings suggest that TM-PKCdelta (show PKCd ELISA Kits) interaction may contribute to cardiovascular disorders by affecting monocye differentiation, which may develop future therapeutic applications.
A heterozygous variant displaying autosomal dominant inheritance (c.1611 C>A) was found in the gene THBD which encodes the glycoprotein thrombomodulin. This sequence change results in a stop codon (p.Cys537Stop) and truncation of the protein
Lys (show LYZ ELISA Kits) 42, Lys (show LYZ ELISA Kits) 43, Lys (show LYZ ELISA Kits) 44 and Arg 12 are critical for the interaction of TAFI (show CPB2 ELISA Kits) with the thrombin (show F2 ELISA Kits)-thrombomodulin complex, which modulates its antifibrinolytic potential.
Ligation of anti-HLA class I and II antibodies produces different effects on the endothelial expression of TBM and on serum levels of TBM in transplant recipients.
Fibrinogen gamma acts as thrombomodulin II. (Review)
Thrombomodulin (TM) promotes angiogenesis by enhancing cell adhesion, migration, and FAK (show PTK2 ELISA Kits) activation through interaction with fibronectin (show FN1 ELISA Kits).
The elevation of serum thrombomodulin (sTM)level suggests that endothelial damage occurs in Abdominal Aortic Aneurysm pathogenesis.
This population-based cohort study within the ARIC study did not replicate the Hernandez et al. finding that carrying the minor allele of 3 THBD SNPs doubles the risk of venous thromboembolism in African Americans. In fact, the HRs of VTE among carriers of the minor allele were <1. HRs were similar for white subjects. A strand-flip did not explain the discrepancies.
these results suggest a novel function for thrombomodulin as an adhesion molecule in monocytes, where it enhances cell adhesion by binding Ley, leading to beta2 integrin activation via p38 MAPK
TM, especially TME45, maintains vascular integrity, at least in part, via Src (show SRC ELISA Kits) signaling.
macrophage infiltration and neointima formation following arterial ligation-induced vascular injury were higher in wild-type than in myeloid-specific thrombomodulin-deficient mice
discovery of a novel physiological function of thrombomodulin-dependent activated protein C (show PROC ELISA Kits) generation within the CNS
The present study found that the fifth epidermal growth factor (show EGF ELISA Kits)-like domain of thrombomodulin (TME5) possesses the cytoprotective function in association with an increase in levels of anti-apoptotic myeloid cell leukemia-1 protein in an activated protein C (show PROC ELISA Kits)-independent
the lectin-like domain of thrombomodulin is critically involved in host defence against E. coli induced acute pyelonephritis
Identified Nur77 (show NR4A1 ELISA Kits)/Nor1 (show NR4A3 ELISA Kits) as novel regulators of thrombomodulin expression and function in vascular endothelial cells.
TM expression in corneal epithelium was modulated during the corneal wound healing process, and may be regulated by PDGF (show PDGFA ELISA Kits)-BB. In addition, rTMD23 has therapeutic potential in corneal injury
Thrombomodulin contributes to gamma tocotrienol-mediated lethality protection and hematopoietic cell recovery in irradiated mice
the recombinant epidermal growth factor (show EGF ELISA Kits)-like domain plus serine/threonine-rich domain of thrombomodulin suppresses the inflammatory response in mice
Thrombomodulin may modulate allergic responses by inhibiting the activation of both eosinophils and mast cells.
Thrombomodulin modulates dendritic cells via both antagonism of high mobility group protein B1 (show HMGB1 ELISA Kits) and an independent mechanism.
Atorvastin induces THBD expression in the aorta of cholesterol-fed rabbits.
The protein encoded by this intronless gene is an endothelial-specific type I membrane receptor that binds thrombin. This binding results in the activation of protein C, which degrades clotting factors Va and VIIIa and reduces the amount of thrombin generated. Mutations in this gene are a cause of thromboembolic disease, also known as inherited thrombophilia.
, CD141 antigen
, snoRNA MBII-339