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The protein encoded by TMPO resides in the nucleus and may play a role in the assembly of the nuclear lamina, and thus help maintain the structural organization of the nuclear envelope. Additionally we are shipping Thymopoietin Kits (10) and Thymopoietin Proteins (10) and many more products for this protein.
Showing 10 out of 112 products:
Dog (Canine) Monoclonal Thymopoietin Primary Antibody for IF, WB - ABIN968307
Dechat, Gotzmann, Stockinger, Harris, Talle, Siekierka, Foisner: Detergent-salt resistance of LAP2alpha in interphase nuclei and phosphorylation-dependent association with chromosomes early in nuclear assembly implies functions in nuclear structure dynamics. in The EMBO journal 1998
Show all 5 Pubmed References
Human Polyclonal Thymopoietin Primary Antibody for ICC, IF - ABIN4359431
Stadler, Hjelmare, Neumann, Jonasson, Pepperkok, Uhlén, Lundberg: Systematic validation of antibody binding and protein subcellular localization using siRNA and confocal microscopy. in Journal of proteomics 2012
Study found TMPO is significantly upregulated in glioblastoma tissues.TMPO knockdown promoted cell apoptosis by upregulation of the cleavage of caspase-3 (show CASP3 Antibodies) and PARP (show COL11A2 Antibodies) protein levels.
The findings unveil a unique mechanism where the nuclear periphery proteins lamin-A/C (show LMNA Antibodies), LAP2alpha and BAF1 are assembled into a protein complex during mitosis in order to regulate assembly and positioning of the mitotic spindle.
The authors find that LAP2alpha (lamina-associated polypeptide-alpha) interacts with lamin A (show LMNA Antibodies), while its interaction with progerin is significantly reduced.
Results highlight the interactions at the nuclear envelope where mutations in the EMD (show EMD Antibodies) and TMPO gene in combination with mutations in SUN1 (show SUN1 Antibodies) have an impact on several components of the network.
Data indicate that cells lacking either high mobility group (show SSRP1 Antibodies) protein N5 (HMGN5 (show HMGN5 Antibodies)) and lamina-associated polypeptide 2alpha (LAP2alpha) showed that loss of either protein affects the genome-wide distribution of the remaining partner.
this study provides evidence for elevated LAP2alpha expression in cervical cancer and suggests that E2F (show E2F1 Antibodies) and p53 (show TP53 Antibodies) activities associate with the positive and negative regulation of LAP2alpha expression, respectively
data suggest that hypophosphorylated Rb is anchored in the nucleus by the interaction of pocket C with LAP2alpha-lamin A/C (show LMNA Antibodies) complexes
Results indicate that in vitro, the interaction between HA95 (show AKAP8L Antibodies) and LAP2beta is influenced by a PKA-mediated phosphorylation of HA95 (show AKAP8L Antibodies) rather than by CDK1 (show CDK1 Antibodies)- or PKC (show PRRT2 Antibodies)-mediated phosphorylation of LAP2beta
LAP2alpha and BAF (show BANF1 Antibodies) transiently localize to telomeres and specific regions on chromatin during nuclear assembly
A predicted Arg690Cys substitution within the LAP2 (show ERBB2IP Antibodies) gene is implicated in the pathogenesis of genetic forms of dilated cardiomyopathy.
Lamin (show LMNA Antibodies)-associated polypeptide (LAP)2 beta assembles around only alternative oocyte chromatin after complete dephosphorylation of histone H3 (show HIST3H3 Antibodies) following fertilization and activation. (lamina-associated polypeptide 2; LAP2beta)
Lifespan and body mass were increased in Lmna (show LMNA Antibodies)(-/-)Lap2alpha(-/-) mice compared with Lmna (show LMNA Antibodies) deficient mice.
Data indicate that a LAP2alpha-independent assembly defect of DeltaK32 lamin A/C (show LMNA Antibodies) is the cause of the pathology, whereas the LAP2alpha-linked functions of nucleoplasmic lamin A/C (show LMNA Antibodies) in the regulation of tissue progenitor cells are not affected in Lmna (show LMNA Antibodies)(DeltaK32/DeltaK32) mice.
LAP2alpha serves as a transcriptional co-regulator, which controls muscle specific (show EIF3K Antibodies) gene expression during muscle regeneration, muscle remodeling and stress response.
TSLP (show TSLP Antibodies) diverts airway tolerance against ovalbumin (show OVA Antibodies) (OVA) to T helper cell type (Th)2 sensitization and inhibits the generation of OVA-specific inducible regulatory T cells.
The age-related down-regulation of Wnt4 (show WNT4 Antibodies) (and subsequently FoxN1 (show FOXN2 Antibodies)), and the prominent increase in LAP2alpha expression, was investigated in thymic epithelial cells.
Our data demonstrate multiple and distinct functions of LAP2 alpha in muscle stem cell maintenance, early phases of myogenic differentiation, and muscle remodeling.
Data show that LAP2alpha knockout caused systolic dysfunction in young mice, sporadic fibrosis in old animals, and disregulation of cardiac GATA4 (show GATA4 Antibodies) and MEF2c (show MEF2C Antibodies), while dstrophin deficiency in Mdx (show DMD Antibodies) mice resulted in a transient rescue of Lap2alpha(-/-) phenotype.
In agreement with its regulation by E2F (show E2F1 Antibodies), LAP2alpha over expression in primary tumors was found to be correlated with tumor proliferation rate
Loss of LAP2-Lmna (show LMNA Antibodies) complexes causes erythroid and epidermal progenitor hyperproliferation.
The protein encoded by this gene resides in the nucleus and may play a role in the assembly of the nuclear lamina, and thus help maintain the structural organization of the nuclear envelope. It may function as a receptor for the attachment of lamin filaments to the inner nuclear membrane. Mutations in this gene are associated with dilated cardiomyopathy. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
, lamina-associated polypeptide 2, isoform alpha-like
, TP beta
, Thymopoietin (lamina associated polypeptide 2)
, lamina-associated polypeptide 2
, thymopoietin isoform beta
, LEM domain containing 4
, TP alpha
, TP beta/gamma
, thymopoietin-related peptide isoform alpha
, thymopoietin-related peptide isoforms beta/gamma
, lamina associated polypeptide 2
, lamin-associated polypeptide 2beta
, thymopoietin II
, lamina-associated protein 2