Titin Proteins

TTN encodes a large abundant protein of striated muscle.

Data Quality
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Type
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    Protein
Antigen
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Reactivity
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Application
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Host
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Binding Specificity
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Conjugate
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Protein Type
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Format
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6 Products
Recombinant Protein, Wheat germ (Source)
ReactivityHuman
Application AA, AP, ELISA, WB
Order details Cat. No. ABIN1324073
$414.29
Plus shipping costs $45.00 and $22.00 dry ice
Delivery in 11 to 12 Business Days
Recombinant Protein, Wheat germ (Source)
ReactivityHuman
Application AA, AP, ELISA, WB
Order details Cat. No. ABIN1324075
$414.29
Plus shipping costs $45.00 and $22.00 dry ice
Delivery in 11 to 12 Business Days
Recombinant Protein, Wheat germ (Source)
ReactivityHuman
Application AA, AP, ELISA, WB
Order details Cat. No. ABIN1324077
$414.29
Plus shipping costs $45.00 and $22.00 dry ice
Delivery in 11 to 12 Business Days
Recombinant Protein, Escherichia coli (E. coli) (Source), Purity > 90 %
ReactivityHuman
Application SDS
Order details Cat. No. ABIN5712956
$550.00
Plus shipping costs $45.00
Will be delivered in 11 Business Days
Recombinant Protein, Escherichia coli (E. coli) (Source), Purity > 95 %
ReactivityHuman
Application ELISA, IP, SDS, WB
Order details Cat. No. ABIN3011907
$745.70
Plus shipping costs $45.00
Delivery in 11 to 18 Business Days
Recombinant Protein, Escherichia coli (E. coli) (Source), Purity > 95 %
ReactivityHuman
Application IP, SDS, ELISA, WB
Order details Cat. No. ABIN2122240
$752.00
Plus shipping costs $45.00
Delivery in 15 to 18 Business Days
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Titin (TTN) Protein Profile

Protein Summary

This gene encodes a large abundant protein of striated muscle. The product of this gene is divided into two regions, a N-terminal I-band and a C-terminal A-band. The I-band, which is the elastic part of the molecule, contains two regions of tandem immunoglobulin domains on either side of a PEVK region that is rich in proline, glutamate, valine and lysine. The A-band, which is thought to act as a protein-ruler, contains a mixture of immunoglobulin and fibronectin repeats, and possesses kinase activity. An N-terminal Z-disc region and a C-terminal M-line region bind to the Z-line and M-line of the sarcomere, respectively, so that a single titin molecule spans half the length of a sarcomere. Titin also contains binding sites for muscle associated proteins so it serves as an adhesion template for the assembly of contractile machinery in muscle cells. It has also been identified as a structural protein for chromosomes. Alternative splicing of this gene results in multiple transcript variants. Considerable variability exists in the I-band, the M-line and the Z-disc regions of titin. Variability in the I-band region contributes to the differences in elasticity of different titin isoforms and, therefore, to the differences in elasticity of different muscle types. Mutations in this gene are associated with familial hypertrophic cardiomyopathy 9, and autoantibodies to titin are produced in patients with the autoimmune disease scleroderma.

Gene names and symbols associated with Titin Proteins (TTN)

  • titin (TTN) antibody
  • titin (Ttn) antibody
  • titin (titin) antibody
  • titin (TTNLOC100620261) antibody
  • 1100001C23Rik antibody
  • 2310036G12Rik antibody
  • 2310057K23Rik antibody
  • 2310074I15Rik antibody
  • AF006999 antibody
  • AV006427 antibody
  • CMD1G antibody
  • CMH9 antibody
  • CMPD4 antibody
  • D330041I19Rik antibody
  • D830007G01Rik antibody
  • EOMFC antibody
  • HMERF antibody
  • L56 antibody
  • LGMD2J antibody
  • mdm antibody
  • MYLK5 antibody
  • shru antibody
  • TMD antibody
  • UNC-22 antibody

Protein level used designations for Titin Proteins (TTN)

connectin , rhabdomyosarcoma antigen MU-RMS-40.14 , titin protein homolog , titin

GENE ID SPECIES
7273 Homo sapiens
22138 Mus musculus
84015 Rattus norvegicus
424126 Gallus gallus
540561 Bos taurus
1791505 Rhodopirellula baltica SH 1
100008570 Oryctolagus cuniculus
100620261 Sus scrofa
100722767 Cavia porcellus