anti-Topoisomerase (DNA) II beta 180kDa Antibodies
TOP2B encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription.
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anti-Topoisomerase (DNA) II beta 180kDa (TOP2B) (C-Term) antibody Primary Antibody
anti-Topoisomerase (DNA) II beta 180kDa (TOP2B) antibody Primary Antibody
anti-Topoisomerase (DNA) II beta 180kDa (TOP2B) (N-Term) antibody Primary Antibody
anti-Topoisomerase (DNA) II beta 180kDa (TOP2B) (Middle Region) antibody Primary Antibody
anti-Topoisomerase (DNA) II beta 180kDa (TOP2B) (AA 1-50) antibody Primary Antibody
anti-Topoisomerase (DNA) II beta 180kDa (TOP2B) (Middle Region) antibody Primary Antibody
anti-Topoisomerase (DNA) II beta 180kDa (TOP2B) (AA 446-655) antibody Primary Antibody
anti-Topoisomerase (DNA) II beta 180kDa (TOP2B) (AA 1411-1523) antibody Primary Antibody
anti-Topoisomerase (DNA) II beta 180kDa (TOP2B) (N-Term) antibody Primary Antibody
anti-Topoisomerase (DNA) II beta 180kDa (TOP2B) (AA 1548-1597) antibody Primary Antibody
anti-Topoisomerase (DNA) II beta 180kDa (TOP2B) (AA 1439-1488) antibody Primary Antibody
anti-Topoisomerase (DNA) II beta 180kDa (TOP2B) (AA 10-90), (N-Term) antibody Primary Antibody
anti-Topoisomerase (DNA) II beta 180kDa (TOP2B) (N-Term) antibody Primary Antibody
anti-Topoisomerase (DNA) II beta 180kDa (TOP2B) (N-Term) antibody Primary Antibody
anti-Topoisomerase (DNA) II beta 180kDa (TOP2B) antibody Primary Antibody
Topoisomerase (DNA) II beta 180kDa (TOP2B) Antigen Profile
Protein Summary
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, beta, is localized to chromosome 3 and the alpha form is localized to chromosome 17. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. Alternative splicing of this gene results in two transcript variants\; however, the second variant has not yet been fully described.
Gene names and symbols associated with TOP2B
- DNA topoisomerase II beta (TOP2B) antibody
- topoisomerase (DNA) II beta (Top2b) antibody
- DNA topoisomerase II beta (Top2b) antibody
- microRNA 4442 (MIR4442) antibody
- D230016L12Rik antibody
- Top-2 antibody
- TOP2B antibody
- top2beta antibody
- TOPIIB antibody
Protein level used designations for TOP2B
topoisomerase (DNA) II beta 180kDa , DNA topoisomerase II, beta isozyme , DNA topoisomerase 2-beta , topoisomerase II beta , DNA topoisomerase II beta , DNA topoisomerase II, 180 kD , U937 associated antigen , antigen MLAA-44 , topo II beta , topoisomerase IIb , DNA topoisomeraseII_beta , topoisomerase II beta-2
GENE ID | SPECIES |
---|---|
460232 | Pan troglodytes |
21974 | Mus musculus |
361100 | Rattus norvegicus |
7155 | Homo sapiens |
395966 | Gallus gallus |
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