Transcobalamin II Proteins (TCN2)

TCN2 encodes a member of the vitamin B12-binding protein family. Additionally we are shipping Transcobalamin II Antibodies (55) and Transcobalamin II Kits (30) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TCN2 21452 O88968
TCN2 64365 Q9R0D6
TCN2 6948 P20062
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Top Transcobalamin II Proteins at

Showing 10 out of 13 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
Human Cells Human His tag 10 μg Log in to see 14 to 16 Days
Human Cells Mouse His tag 10 μg Log in to see 14 to 16 Days
CHO Cells Human His tag 50 μg Log in to see 14 to 16 Days
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
Escherichia coli (E. coli) Rat Un-conjugated SDS-PAGE analysis of Rat TCN2 Protein. 100 μg Log in to see 11 to 18 Days
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
Yeast Orang-Utan His tag   1 mg Log in to see 60 to 71 Days
Yeast Cow His tag   1 mg Log in to see 60 to 71 Days

TCN2 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,

Rat (Rattus) ,
Human , , , ,
, ,

More Proteins for Transcobalamin II (TCN2) Interaction Partners

Human Transcobalamin II (TCN2) interaction partners

  1. 12 articles were included in this study. The pooled results did not reveal a significant association of the MTRR A66G polymorphism (G vs. A: OR = 0.99, 95% CI = 0.82-1.18, p = 0.72) with Nonsyndromic Cleft Lip With or Without Cleft Palate risk

  2. The findings of the present case-control study did not support an association between the TCN2 rs1801198 and TCN2R rs2336573 polymorphisms and the risk of recurrent spontaneous abortion in a sample of the Iranian population.

  3. Genotypes of transcobalamin 2 (TCN2) rs1801198, methionine synthase (MTR) rs1805087, methionine synthase reductase (MTRR) rs1801394, and methylene tetrahydrofolate reductase (MTHFR) rs1801133 were examined in 201 children with Autism Spectrum Disorder and 200 healthy controls from the Han Chinese population. Our results showed no association of all examined SNPs with childhood ASD and its severity.

  4. Proteomics analysis of glioblastoma cell line under hypoxia identified B12 transporter protein TCN2, which is essential for one-carbon metabolism, as being significantly downregulated. TCN2 downregulation seems to play an important role in controlling cell transformation to a highly aggressive mesenchymal/cancer stem cell (CSC), whereas high expression of TCN2 can reverse it.

  5. TCN2 (rs1801198, rs9606756) variations, as well as serum levels of Hcy, vitamin B12 and folate, are correlated with ulcerative colitis.

  6. tagSNPs in MTHFR, MTR, MTRR, and TCN2 were not associated with NSCLP in our study, but continued exploration, including allele frequency of various populations and molecular mechanism of the gene-gene interactions of the genes, may provide additional insight into NSCLP.

  7. TCN2 (rs1801198, rs9606756) polymorphisms as well as folate deficiency and vitamin B12 deficiency are correlated with Crohn's disease.

  8. The rs9606756[c.67A>G,p.Ile23Val] variant from TCN2 was associated with waist circumference (WC) at nearly genome-wide significance (P = 8.92E-08).

  9. TC deficiency has a wide heterogeneity in clinical phenotype, genotype, laboratory, and radiologic findings. Early detection of the disease and early initiation of aggressive parenteral treatment is probably associated with better prognosis and disease control.

  10. Meta-analysis results indicate an influence of rs1801198 on holotranscobalamin and homocysteine concentrations in European-descent subjects.

  11. TCN2 polymorphism is associated with ulcerative colitis.

  12. A novel homozygous mutation (c.1106+1516_1222+1231del) was detected in 7 patients from 5 families. A 5304-bp deletion that begins 1516 bp into intron 7 and ends 1231 bp into intron 8 was observed. The deletion includes all of exon 8 and causes a frameshift to produce a premature stop of 4 codons into the new reading frame (counting ATG as 1).

  13. The association of the TCN2 polymorphism with peripheral neuropathy was independent of vitamin B-12 intake.

  14. G/G homozygosity of C776G TC2 and the C/G genotype of the C776G TC2 genegene polymorphism increases the risk of oral cancer

  15. The mutation does not seem to interfere with the function of TC, but the mutation may well explain the low level of holoTC detected by the Abbott assay. The results underscores that mutations of TCN2 have to be considered when implausible holoTC results are obtained.

  16. 4 patients with transcobalamin II deficiency were found to have novel mutations, of whom 2 had the same large deletion (homozygous c.1106+1516-1222+1231del). One had c.1107- 347_1222+981delin 364. Another had homozygous c.106C>T. (Q36X).

  17. There were no other associations between single -nucleotide polymorphisms and the efficacy of MTX treatment. CONCLUSIONS: The MTHFR 677CC and GGH 401TT and CT genotypes were associated with a reduction in the number of MTX-related adverse events.

  18. Report TCN2 mutations causing transcobalamin deficiency in an Indian patient.

  19. Although not significant when corrected for multiple testing, eight single nucleotide polymorphisms (SNPs) in two genes, transcobalamin II (TCN2) and the transcobalamin II-receptor (TCblR), were found to influence several clinical traits of cobalamin deficiency.

  20. In Asian populations, the investigated polymorphisms mapping at TCN2 and CBS genes did not provide any evidence of association with cleft lip/cleftpalate.

Cow (Bovine) Transcobalamin II (TCN2) interaction partners

  1. study investigated crystallographically the beta-ligand exchange on Cbl bound to transcobalamin (TC) by crystallization of bovine holo-TC in the presence of either cyanide or sulfite

Transcobalamin II (TCN2) Protein Profile

Protein Summary

This gene encodes a member of the vitamin B12-binding protein family. This family of proteins, alternatively referred to as R binders, is expressed in various tissues and secretions. This plasma protein binds cobalamin and mediates the transport of cobalamin into cells. This protein and other mammalian cobalamin-binding proteins, such as transcobalamin I and gastric intrisic factor, may have evolved by duplication of a common ancestral gene. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with Transcobalamin II Proteins (TCN2)

  • transcobalamin 2 (Tcn2)
  • transcobalamin 2 (TCN2)
  • AW208754 protein
  • D22S676 protein
  • D22S750 protein
  • II protein
  • TC protein
  • TC-2 protein
  • TC2 protein
  • TC II protein
  • TCII protein
  • Tcn-2 protein
  • Tcn2p protein

Protein level used designations for Transcobalamin II Proteins (TCN2)

TC II , TC-2 , TCII , transcobalamin II , transcobalamin-2 , macrocytic anemia , transcobalamin II; macrocytic anemia , vitamin B12-binding protein 2

21452 Mus musculus
64365 Rattus norvegicus
6948 Homo sapiens
281518 Bos taurus
100171681 Pongo abelii
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