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TCN2 encodes a member of the vitamin B12-binding protein family. Additionally we are shipping Transcobalamin II Antibodies (53) and Transcobalamin II Kits (29) and many more products for this protein.
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Genotypes of transcobalamin 2 (TCN2) rs1801198, methionine synthase (MTR (show MTR Proteins)) rs1805087, methionine synthase reductase (MTRR (show MTRR Proteins)) rs1801394, and methylene tetrahydrofolate reductase (MTHFR (show MTHFR Proteins)) rs1801133 were examined in 201 children with Autism Spectrum Disorder and 200 healthy controls from the Han Chinese population. Our results showed no association of all examined SNPs with childhood ASD (show ARSD Proteins) and its severity.
Proteomics analysis of glioblastoma cell line under hypoxia identified B12 (show NDUFB3 Proteins) transporter protein (show HNRNPU Proteins) TCN2, which is essential for one-carbon metabolism, as being significantly downregulated. TCN2 downregulation seems to play an important role in controlling cell transformation to a highly aggressive mesenchymal/cancer stem cell (CSC), whereas high expression of TCN2 can reverse it.
TCN2 (rs1801198, rs9606756) variations, as well as serum levels of Hcy, vitamin B12 (show NDUFB3 Proteins) and folate, are correlated with ulcerative colitis.
tagSNPs in MTHFR (show MTHFR Proteins), MTR (show MTR Proteins), MTRR (show MTRR Proteins), and TCN2 were not associated with NSCLP in our study, but continued exploration, including allele frequency of various populations and molecular mechanism of the gene-gene interactions of the genes, may provide additional insight into NSCLP.
TCN2 (rs1801198, rs9606756) polymorphisms as well as folate deficiency and vitamin B12 (show NDUFB3 Proteins) deficiency are correlated with Crohn's disease.
The rs9606756[c.67A>G,p.Ile23Val] variant from TCN2 was associated with waist circumference (WC) at nearly genome-wide significance (P = 8.92E-08).
TCN2 polymorphism is associated with ulcerative colitis.
The association of the TCN2 polymorphism with peripheral neuropathy was independent of vitamin B-12 intake.
G/G homozygosity of C776G TC2 and the C/G genotype of the C776G TC2 genegene polymorphism increases the risk of oral cancer
The mutation does not seem to interfere with the function of TC, but the mutation may well explain the low level of holoTC detected by the Abbott assay. The results underscores that mutations of TCN2 have to be considered when implausible holoTC results are obtained.
study investigated crystallographically the beta-ligand exchange on Cbl bound to transcobalamin (TC) by crystallization of bovine holo-TC in the presence of either cyanide or sulfite
This gene encodes a member of the vitamin B12-binding protein family. This family of proteins, alternatively referred to as R binders, is expressed in various tissues and secretions. This plasma protein binds cobalamin and mediates the transport of cobalamin into cells. This protein and other mammalian cobalamin-binding proteins, such as transcobalamin I and gastric intrisic factor, may have evolved by duplication of a common ancestral gene. Alternative splicing results in multiple transcript variants.
, transcobalamin II
, macrocytic anemia
, transcobalamin II; macrocytic anemia
, vitamin B12-binding protein 2