TCN2 Protein (His tag)
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- Target See all TCN2 Proteins
- TCN2 (Transcobalamin II (TCN2))
- Protein Type
- Recombinant
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Origin
- Mouse
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This TCN2 protein is labelled with His tag.
- Purpose
- Recombinant Mouse TCN2 Protein (His Tag)
- Sequence
- Met 1-Trp 430
- Characteristics
- A DNA sequence encoding the mouse TCN2 (O88968) (Met 1-Trp 430) was expressed, with a C-terminal polyhistidine tag.
- Purity
- > 95 % as determined by SDS-PAGE
- Endotoxin Level
- < 1.0 EU per μg of the protein as determined by the LAL method.
- Top Product
- Discover our top product TCN2 Protein
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Transcobalamin II (TCN2) (AA 20-427) protein (GST tag)
TCN2 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Transcobalamin II (TCN2) (AA 1-400) protein (GST tag)TCN2 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Transcobalamin II (TCN2) (AA 19-427) protein (His tag)Crystallography grade TCN2 Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Transcobalamin II (TCN2) (AA 19-430) protein (His tag)Crystallography grade TCN2 Origin: Mouse Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from sterile PBS, pH 7.4
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Target
- TCN2 (Transcobalamin II (TCN2))
- Alternative Name
- TCN2 (TCN2 Products)
- Synonyms
- AW208754 Protein, Tcn-2 Protein, Tc2 Protein, Tcn2p Protein, D22S676 Protein, D22S750 Protein, II Protein, TC Protein, TC II Protein, TC-2 Protein, TC2 Protein, TCII Protein, transcobalamin 2 Protein, Tcn2 Protein, TCN2 Protein
- Background
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Background: Transcobalamin II, also known as TCN2 and TC II, is a plasma protein that binds cobalamin (Cbl, vitamin B12) as it is absorbed in the terminal ileum and distributes to tissues. The circulating transcobalamin II-cobalamin complex binds to receptors on the plasma membrane of tissue cells and is then internalized by receptor-mediated endocytosis. Transcobalamin II is a non-glycolated secretory protein of molecular mass 43 kDa. Its plasma membrane receptor (TC II-R) is a heavily glycosylated protein with a monomeric molecular mass of 62 kDa. Human TCN2 gene is composed of nine exons and eight introns spanning approximately 20 kb with multiple potential transcription start sites. A number of genetic abnormalities are characterized either by a failure to express TCN2 or by synthesis of an abnormal protein. The TCN2 deficiency results in cellular cobalamin deficiency, an early onset of megaloblastic anaemia, and neurological abnormalities.
Synonym: AW208754,Tcn-2
- Molecular Weight
- 47 kDa
- UniProt
- O88968
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