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The protein encoded by TCEA2 is found in the nucleus, where it functions as an SII class transcription elongation factor.
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RNA polymerase II (show 0 Antibodies) complexes in the very early phase of transcription are not susceptible to TFIIS (show TCEA1 Antibodies)-induced exonucleolytic cleavage.
data suggest that because TFIIS promotes escape from promoter-proximal pauses by stimulating cleavage of back-tracked nascent RNA, TFIIS inhibition may help DSIF/NELF negatively regulate productive transcription
SII (show TCEA1 Antibodies) is important for preventing cellular death due to oxidative DNA damage, assisting RNAPII (show 0 Antibodies) to bypass 8-oxoG
The protein encoded by this gene is found in the nucleus, where it functions as an SII class transcription elongation factor. Elongation factors in this class are responsible for releasing RNA polymerase II ternary complexes from transcriptional arrest at template-encoded arresting sites. The encoded protein has been shown to interact with general transcription factor IIB, a basal transcription factor. Two transcript variants encoding different isoforms have been found for this gene.
transcription elongation factor A protein 2
, testis-specific S-II
, transcription elongation factor S-II protein 2
, transcription elongation factor TFIIS.1
, transcription elongation factor TFIIS.l
, transcription elongation factor A2