anti-Transcription Elongation Factor SPT5 (SUPT5H) Antibodies

Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. Additionally we are shipping Transcription Elongation Factor SPT5 Proteins (7) and Transcription Elongation Factor SPT5 Kits (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SUPT5H 6829 O00267
SUPT5H 308472  
SUPT5H    
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Top anti-Transcription Elongation Factor SPT5 Antibodies at antibodies-online.com

Showing 10 out of 51 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated IHC, WB Human kidney Human Pancreas 100 μL Log in to see 2 to 3 Days
$319.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-SUPT5H Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:1562500  Positive Control:  Jurkat cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB SUPT5H Antibody (Center) (ABIN658454) western blot analysis in Jurkat cell line lysates (35 µg/lane). This demonstrates the SUPT5H antibody detected the SUPT5H protein (arrow). 400 μL Log in to see 10 to 11 Days
$385.00
Details
Human Mouse Un-conjugated IF, IHC, WB Immunofluorescence of monoclonal antibody to SUPT5H on HeLa cell (antibody concentration 10 µg/mL). SUPT5H monoclonal antibody (M01), clone 3F1 Western Blot analysis of SUPT5H expression in Hela NE. 100 μg Log in to see 8 to 11 Days
$527.50
Details
Human Mouse Un-conjugated IF, WB Immunofluorescence of monoclonal antibody to SUPT5H on HeLa cell (antibody concentration 10 µg/mL). SUPT5H monoclonal antibody (M03), clone 3B1 Western Blot analysis of SUPT5H expression in Hela NE. 100 μg Log in to see 8 to 11 Days
$527.50
Details
Cow Rabbit Un-conjugated IHC, IHC (p), WB 50 μg Log in to see 11 to 14 Days
$551.83
Details
Cow Rabbit Un-conjugated WB 50 μg Log in to see 11 to 14 Days
$551.83
Details
Human Rabbit Un-conjugated IHC (p), IHC, WB Immunohistochemistry-Paraffin: SUPT5H Antibody [ABIN2582273] - FFPE section of human breast adenocarcinoma. Affinity purified rabbit anti-SUPT5H used at a dilution of 1:250. 100 μL Log in to see 7 to 9 Days
$559.35
Details
Human Rabbit Un-conjugated IP 100 μL Log in to see 7 to 9 Days
$559.35
Details
Human Rabbit Un-conjugated WB Western blot analysis in Jurkat cell line lysates (35ug/lane). 400 μL Log in to see 2 to 3 Days
$515.63
Details

Top referenced anti-Transcription Elongation Factor SPT5 Antibodies

  1. Cow (Bovine) Polyclonal SUPT5H Primary Antibody for WB - ABIN2778245 : Ueki, Lin, Senoo, Ebihara, Agata, Onji, Saheki, Kawai, Mukherjee, Reichenberger, Olsen: Increased myeloid cell responses to M-CSF and RANKL cause bone loss and inflammation in SH3BP2 "cherubism" mice. in Cell 2007 (PubMed)
    Show all 2 Pubmed References

  2. Human Polyclonal SUPT5H Primary Antibody for IHC (p), IHC - ABIN258227 : Lu, Xue, Xue, Yu, Arias, Lin, Fong, Faure, Weisburd, Ji, Mercier, Sutton, Luo, Gao, Zhou: Compensatory induction of MYC expression by sustained CDK9 inhibition via a BRD4-dependent mechanism. in eLife 2015 (PubMed)

More Antibodies against Transcription Elongation Factor SPT5 Interaction Partners

Human Transcription Elongation Factor SPT5 (SUPT5H) interaction partners

  1. These findings are consistent with a central role of Spt5 in maintenance of TFIID-promoter association and promoter escape to support rapid transcriptional induction and re-initiation of inflammatory-response genes.

  2. The mobile C-terminal region of DSIF is located near exiting RNA, where it can recruit factors for RNA processing.

  3. OGA is physically associated with the known RNA polymerase II (pol II) pausing/elongation factors SPT5 and TRIM28-KAP1-TIF1beta, and a purified OGA-SPT5-TIF1beta complex has elongation properties.

  4. A transcription-independent effect of tumor necrosis factor alpha on RNA splicing, mediated by Spt5.

  5. SPT5 contributes to the up-regulation of hTERT expression and colonic tumor development.

  6. Data indicate that the Plus3 domain of the Rtf1 subunit mediates Paf1C recruitment to genes by binding a repeating domain within the phosphorylated elongation factor Spt5.

  7. DSIF Is Selectively Required for mRNA Splicing and Export of NF-kappaB Target Genes.

  8. RNA polymerase II elongation repression is critically dependent on the C-terminus of Spt5

  9. crystal structure of hSpt4 in complex with the dimerization region of hSpt5

  10. phosphorylated by P-TEFb kinase during HIV-1 transcription in Tat/TAR dependent manner

  11. hSpt5 function in transcription regulation and mRNA capping is essential for a subset of cellular and viral genes and may not be required for global gene expression.

  12. evolutionarily conserved repetitive heptapeptide motif (consensus = G-S-R/Q-T-P) in the C-terminal region of hSpt5, like the C-terminal domain of RNA Pol II, is highly phosphorylated by P-TEFb

  13. Upon induction of NF-kappaB, a subset of target genes is regulated differentially by either P-TEFb or DSIF.[P-TEFb, DSIF]

  14. These findings reveal a dynamic regulation of DSIF involving either E-box or NF-kappaB depending on the physiological circumstances.

  15. These results suggest that one of the functions of Spt5 is to suppress senescence and apoptosis, and that this function is exerted through its association with Spt4 and Pol II.

  16. he Paf1 complex (Paf1C) and Tat-SF1, two factors implicated previously in elongation control, collaborate with DSIF to facilitate efficient elongation

  17. phosphorylation by cdk9; binds pin1 protein after phosphorylation

Arabidopsis thaliana Transcription Elongation Factor SPT5 (SUPT5H) interaction partners

  1. The phosphorylation of SPT5 by CDKD;2 enables it to recruit VIP5 to regulate chromatin and transcription in Arabidopsis.

  2. SPT5-like protein emerged in plants as a facultative RNA polymerase elongation factor.[SPT5]

Zebrafish Transcription Elongation Factor SPT5 (SUPT5H) interaction partners

  1. the positive function of Foggy/Spt5 is required for gata1 expression during zebrafish embryonic hematopoiesis.

  2. RNA polymerase II elongation repression is critically dependent on the C-terminus of Spt5

  3. The elongation factors Pandora/Spt6 and Foggy/Spt5 promote transcription in the zebrafish embryo.

  4. spt 5-dependent transcript elongation is required cell-autonomously for a complex cell migration

  5. Spt5 as a dual regulator of transcription elongation in vivo; a small but diverse set of target genes critically dependent on Spt5 during development.

Fruit Fly (Drosophila melanogaster) Transcription Elongation Factor SPT5 (SUPT5H) interaction partners

  1. Mutation in the protein-protein interaction domain (REPO domain) of Pho interferes with the dynamics of its interaction with Spt5. The transcriptional kinetics of the heat shock response is negatively affected by a mutation in the REPO domain of Pho

  2. KOW5 is involved in promoter-proximal pausing through contact with the nascent RNA

  3. Spt5 interacts both physically and genetically with the Polycomb Group (PcG) protein Pleiohomeotic (Pho)

  4. We show that SPT5 interacts directly with MSL1 in vitro and is required downstream of MSL complex recruitment, providing the first mechanistic data corroborating the elongation model of dosage compensation.

  5. Spt5 acts both positively and negatively on transcription in vivo during heat shock induction.

Transcription Elongation Factor SPT5 (SUPT5H) Antigen Profile

Protein Summary

Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II. TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme. Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites. DSIF can also positively regulate transcriptional elongation and is required for the efficient activation of transcriptional elongation by the HIV- 1 nuclear transcriptional activator, Tat. DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences.

Gene names and symbols associated with SUPT5H

  • SPT5 homolog, DSIF elongation factor subunit (SUPT5H) antibody
  • transcription elongation factor SPT5 (LOC413814) antibody
  • Transcription elongation factor Spt5 (AT2G34210) antibody
  • transcription elongation factor Spt5 (spt5) antibody
  • transcription elongation factor spt5 (MGYG_08422) antibody
  • transcription elongation factor spt5 (TERG_05483) antibody
  • hypothetical protein (PGTG_18458) antibody
  • SPT5 homolog, DSIF elongation factor subunit (supt5h) antibody
  • SPT5 homolog, DSIF elongation factor subunit (Supt5h) antibody
  • SPT5 homolog, DSIF elongation factor subunit S homeolog (supt5h.S) antibody
  • CG7626 gene product from transcript CG7626-RA (Spt5) antibody
  • Transcription elongation factor SPT5 (spt-5) antibody
  • transcription elongation factor (SPT5) antibody
  • CaO19.1453 antibody
  • CG7626 antibody
  • dDSIF antibody
  • Dmel\\CG7626 antibody
  • DSIF antibody
  • dSpt5 antibody
  • etID10129.15 antibody
  • etID37101.15 antibody
  • F13P17.5 antibody
  • F13P17_5 antibody
  • fb37g01 antibody
  • fb95e05 antibody
  • fog antibody
  • foggy antibody
  • spt5 antibody
  • spt5h antibody
  • tat-ct1 antibody
  • wu:fb37g01 antibody
  • wu:fb95e05 antibody
  • wu:fc10f02 antibody

Protein level used designations for SUPT5H

DRB sensitivity-inducing factor 160 kDa subunit , DRB sensitivity-inducing factor large subunit , DSIF large subunit , DSIF p160 , Tat-cotransactivator 1 protein , hSPT5 , transcription elongation factor SPT5 , transcription elongation factor Spt5 , transcription elongation factor spt5 , protein foggy , transcription elongation regulator foggy , CG7626-PA , Spt5-PA , Chromatin elongation factor SPT5

GENE ID SPECIES
6829 Homo sapiens
413814 Apis mellifera
817982 Arabidopsis thaliana
2541916 Schizosaccharomyces pombe 972h-
10024747 Arthroderma gypseum CBS 118893
10372474 Trichophyton rubrum CBS 118892
10537737 Puccinia graminis f. sp. tritici CRL 75-36-700-3
64275 Danio rerio
308472 Rattus norvegicus
426493 Gallus gallus
476462 Canis lupus familiaris
733281 Xenopus laevis
519808 Bos taurus
53442 Drosophila melanogaster
178143 Caenorhabditis elegans
100713914 Cavia porcellus
3635847 Candida albicans SC5314
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