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SUPT5H Products

(Transcription Elongation Factor SPT5 (SUPT5H))
Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II. TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme. Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites. DSIF can also positively regulate transcriptional elongation and is required for the efficient activation of transcriptional elongation by the HIV- 1 nuclear transcriptional activator, Tat. DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences.

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Featured SUPT5H Categories

SUPT5H Antibodies

High quality antibodies with extensive validation data.

SUPT5H ELISA Kits

Reliable ELISA kits for a wide range of species.

SUPT5H Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended SUPT5H Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IHC, IF
Validations
  • (6)
Cat. No. ABIN7270878
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IF, IHC (p)
Validations
  • (4)
Cat. No. ABIN520620
Quantity 100 μg
Datasheet Datasheet
Reactivity Cow, Dog, Guinea Pig, Horse, Human, Monkey, Mouse, Pig, Rabbit, Rat
Application WB, IHC, IHC (p)
Validations
  • (3)
Cat. No. ABIN6735860
Quantity 100 μL
Datasheet Datasheet

Recommended SUPT5H ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse
Analytical Method
Validations
Cat. No. ABIN1162214
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method
Validations
Cat. No. ABIN1162213
Quantity 96 tests
Datasheet Datasheet
Reactivity Chicken
Analytical Method
Validations
Cat. No. ABIN1162212
Quantity 96 tests
Datasheet Datasheet

Recommended SUPT5H Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1321917
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3095662
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3131899
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our SUPT5H products

Lu, Xue, Xue, Yu, Arias, Lin, Fong, Faure, Weisburd, Ji, Mercier, Sutton, Luo, Gao, Zhou: "Compensatory induction of MYC expression by sustained CDK9 inhibition via a BRD4-dependent mechanism." in: eLife, Vol. 4, pp. e06535, (2015) (PubMed).

Arabi, Ullah, Branca, Johansson, Bandarra, Haneklaus, Fu, Ariës, Nilsson, Den Boer, Pokrovskaja, Grandér, Xiao, Rocha, Lehtiö, Sangfelt: "Proteomic screen reveals Fbw7 as a modulator of the NF-κB pathway." in: Nature communications, Vol. 3, pp. 976, (2012) (PubMed).

Willmann, Milosevic, Pauklin, Schmitz, Rangam, Simon, Maslen, Skehel, Robert, Heyer, Schiavo, Reina-San-Martin, Petersen-Mahrt: "A role for the RNA pol II-associated PAF complex in AID-induced immune diversification." in: The Journal of experimental medicine, Vol. 209, Issue 11, pp. 2099-111, (2012) (PubMed).

Ueki, Lin, Senoo, Ebihara, Agata, Onji, Saheki, Kawai, Mukherjee, Reichenberger, Olsen: "Increased myeloid cell responses to M-CSF and RANKL cause bone loss and inflammation in SH3BP2 "cherubism" mice." in: Cell, Vol. 128, Issue 1, pp. 71-83, (2007) (PubMed).

Amir-Zilberstein, Ainbinder, Toube, Yamaguchi, Handa, Dikstein: "Differential regulation of NF-kappaB by elongation factors is determined by core promoter type." in: Molecular and cellular biology, Vol. 27, Issue 14, pp. 5246-59, (2007) (PubMed).

Synonyms and alternative names related to SUPT5H

SPT5 homolog, DSIF elongation factor subunit (SUPT5H), transcription elongation factor SPT5 (LOC413814), Transcription elongation factor Spt5 (AT2G34210), transcription elongation factor Spt5 (spt5), transcription elongation factor spt5 (MGYG_08422), transcription elongation factor spt5 (TERG_05483), hypothetical protein (PGTG_18458), SPT5 homolog, DSIF elongation factor subunit (supt5h), SPT5 homolog, DSIF elongation factor subunit (Supt5h), SPT5 homolog, DSIF elongation factor subunit S homeolog (supt5h.S), CG7626 gene product from transcript CG7626-RA (Spt5), Transcription elongation factor SPT5 (spt-5), transcription elongation factor (SPT5), CaO19.1453, CG7626, dDSIF, Dmel\\CG7626, DSIF, Dspt5, dSpt5, etID10129.15, etID37101.15, F13P17.5, F13P17_5, fb37g01, fb95e05, fog, foggy, SPT5, Spt5, spt5, SPT5H, spt5h, Tat-CT1, tat-ct1, wu:fb37g01, wu:fb95e05, wu:fc10f02

Protein level used designations for SUPT5H

  • DRB sensitivity-inducing factor 160 kDa subunit
  • DRB sensitivity-inducing factor large subunit
  • DSIF large subunit
  • DSIF p160
  • Tat-cotransactivator 1 protein
  • hSPT5
  • transcription elongation factor SPT5
  • transcription elongation factor Spt5
  • transcription elongation factor spt5
  • protein foggy
  • transcription elongation regulator foggy
  • CG7626-PA
  • Spt5-PA
  • Chromatin elongation factor SPT5
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