Transcription Elongation Factor SPT5 Proteins
Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II.
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Transcription Elongation Factor SPT5 (SUPT5H) (AA 1-1087) protein (His tag) Protein
Transcription Elongation Factor SPT5 (SUPT5H) (AA 1-1082) protein (His tag) Protein
Transcription Elongation Factor SPT5 (SUPT5H) (AA 981-1087) protein (GST tag) Protein
Transcription Elongation Factor SPT5 (SUPT5H) (Transcript Variant 4) protein (Myc-DYKDDDDK Tag) Protein
Transcription Elongation Factor SPT5 (SUPT5H) (Transcript Variant 2) protein (Myc-DYKDDDDK Tag) Protein
Transcription Elongation Factor SPT5 (SUPT5H) (Transcript Variant 3) protein (Myc-DYKDDDDK Tag) Protein
Transcription Elongation Factor SPT5 (SUPT5H) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag) Protein
Transcription Elongation Factor SPT5 (SUPT5H) Protein Profile
Protein Summary
Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II. TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme. Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites. DSIF can also positively regulate transcriptional elongation and is required for the efficient activation of transcriptional elongation by the HIV- 1 nuclear transcriptional activator, Tat. DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences.
Gene names and symbols associated with SUPT5H
- SPT5 homolog, DSIF elongation factor subunit (SUPT5H) antibody
- transcription elongation factor SPT5 (LOC413814) antibody
- Transcription elongation factor Spt5 (AT2G34210) antibody
- transcription elongation factor Spt5 (spt5) antibody
- transcription elongation factor spt5 (MGYG_08422) antibody
- transcription elongation factor spt5 (TERG_05483) antibody
- hypothetical protein (PGTG_18458) antibody
- SPT5 homolog, DSIF elongation factor subunit (supt5h) antibody
- SPT5 homolog, DSIF elongation factor subunit (Supt5h) antibody
- SPT5 homolog, DSIF elongation factor subunit S homeolog (supt5h.S) antibody
- CG7626 gene product from transcript CG7626-RA (Spt5) antibody
- Transcription elongation factor SPT5 (spt-5) antibody
- transcription elongation factor (SPT5) antibody
- CaO19.1453 antibody
- CG7626 antibody
- dDSIF antibody
- Dmel\\CG7626 antibody
- DSIF antibody
- dSpt5 antibody
- etID10129.15 antibody
- etID37101.15 antibody
- F13P17.5 antibody
- F13P17_5 antibody
- fb37g01 antibody
- fb95e05 antibody
- fog antibody
- foggy antibody
- spt5 antibody
- spt5h antibody
- tat-ct1 antibody
- wu:fb37g01 antibody
- wu:fb95e05 antibody
- wu:fc10f02 antibody
Protein level used designations for SUPT5H
DRB sensitivity-inducing factor 160 kDa subunit , DRB sensitivity-inducing factor large subunit , DSIF large subunit , DSIF p160 , Tat-cotransactivator 1 protein , hSPT5 , transcription elongation factor SPT5 , transcription elongation factor Spt5 , transcription elongation factor spt5 , protein foggy , transcription elongation regulator foggy , CG7626-PA , Spt5-PA , Chromatin elongation factor SPT5
| GENE ID | SPECIES |
|---|---|
| 6829 | Homo sapiens |
| 413814 | Apis mellifera |
| 817982 | Arabidopsis thaliana |
| 2541916 | Schizosaccharomyces pombe 972h- |
| 10024747 | Arthroderma gypseum CBS 118893 |
| 10372474 | Trichophyton rubrum CBS 118892 |
| 10537737 | Puccinia graminis f. sp. tritici CRL 75-36-700-3 |
| 64275 | Danio rerio |
| 308472 | Rattus norvegicus |
| 426493 | Gallus gallus |
| 476462 | Canis lupus familiaris |
| 733281 | Xenopus laevis |
| 519808 | Bos taurus |
| 53442 | Drosophila melanogaster |
| 178143 | Caenorhabditis elegans |
| 100713914 | Cavia porcellus |
| 3635847 | Candida albicans SC5314 |
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