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The protein encoded by TCF20 binds a platelet-derived growth factor-responsive element in the matrix metalloproteinase 3 (stromelysin 1) promoter. Additionally we are shipping TCF20 Antibodies (25) and TCF20 Kits (18) and many more products for this protein.
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Nonsense and one frameshift variant of TCF20 were identified the patients with intellectual disability and postnatal overgrowth. Such de novo variants of TCF20 may represent a novel differential diagnosis in the overgrowth syndrome spectrum.
mutations in TCF20 are associated with Autism spectrum disorders
SPBP is a transcriptional coactivator of NRF2 regulating expression of the autophagy receptor p62.
evolutionary conservation of chromatin binding of SPBP and RAI1 (show DOM3Z Proteins)
Study has identified SPBP as a transcriptional coactivator of AR. We also show that Pax6 (show PAX6 Proteins) inhibits SPBP-mediated enhancement of AR activity on the AR target gene probasin promoter, a repression that was partly reversed by increased expression of SPBP.
SPBP behaves as a repressor of activated ERalpha (show ESR1 Proteins)
Interaction between SPBP and TopBP1 (show TOPBP1 Proteins) was found to be mediated by the ePHD domain of SPBP and the BRCT6 domain of TopBP1 (show TOPBP1 Proteins).
The protein encoded by this gene binds a platelet-derived growth factor-responsive element in the matrix metalloproteinase 3 (stromelysin 1) promoter. The protein localizes to the nucleus and displays DNA-binding and transactivation activities. It is thought to be a transcriptional coactivator, enhancing the activity of transcription factors such as JUN and SP1. Alternative splicing results in two transcript variants encoding different isoforms.
, nuclear factor SPBP
, stromelysin 1 PDGF responsive element binding protein
, stromelysin 1 PDGF-responsive element-binding protein
, stromelysin PDGF responsive element binding protein transcription factor
, stromelysin-1 PDGF-responsive element-binding protein
, stromelysin-1 platelet-derived growth factor-responsive element binding protein
, transcription factor 20