Transcription Factor E3 Proteins (TFE3)

The microphthalmia transcription factor/transcription factor E (MITF-TFE) family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors includes four family members: MITF, TFE3, TFEB and TFEC. Additionally we are shipping TFE3 Antibodies (113) and TFE3 Kits (7) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TFE3 7030 P19532
TFE3 209446 Q64092
Rat TFE3 TFE3 317376  
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top TFE3 Proteins at antibodies-online.com

Showing 6 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$9,797.11
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$9,797.11
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
Details
Insect cells (Sf9) Human His tag Validation with Western Blot 20 μg Log in to see Available
$504.90
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
$814.00
Details
Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 11 to 18 Days
$582.75
Details

TFE3 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
, ,
Mouse (Murine)

More Proteins for Transcription Factor E3 (TFE3) Interaction Partners

Human Transcription Factor E3 (TFE3) interaction partners

  1. TFE3 gene rearrangement is associated with Epithelioid Rich Perivascular Epithelioid Cell Neoplasm of the Bladder.

  2. The data reveal that 4E-BP3 (show EIF4EBP3 Proteins) expression is controlled by the transcription factor TFE3 through a cis (show CISH Proteins)-regulatory element in the EIF4EBP3 (show EIF4EBP3 Proteins) gene promoter.

  3. Both SOX11 (show SOX11 Proteins) and TFE3 were overexpressed in solid-pseudopapillary neoplasms (SPNs) and may be involved in the pathogenesis.

  4. A Potential G-quadruplex-forming Sequence (PQS) in the intron 2 of the TFE3 gene suggested by in silico studies was confirmed. Increased and decreased formation of G-quadruplex occurred in presence of pyridostatin and antisense oligonucleotide respectively. Stable G-quadruplex formation affected biological processes and TFE3 splicing. G-quadruplex is behind TFE3 induced oncogenesis via translocation and mRNA splicing.

  5. TFE3 may promote renal tumor growth by regulating cell cycle progression and activating the phosphatidylinositol 3kinase/AKT (show AKT1 Proteins) serine/threonine kinase (show TLK2 Proteins) 1/mTOR (show FRAP1 Proteins) signaling pathway.

  6. We report for the first time the presence of both TFE3 translocation and SDHB (show SDHB Proteins) mutation in the same renal cell carcinoma (show MOK Proteins) tumor.

  7. TFEB (show TFEB Proteins) and TFE3 collaborate with each other in activated macrophages and microglia to promote efficient autophagy induction, increased lysosomal biogenesis, and transcriptional upregulation of numerous proinflammatory cytokines

  8. Findings indicated that TFE3 was an important hypoxia-induced transcriptional factor in HNSCC.

  9. Solid pseudopapillary neoplasms (SPNs) showed positive staining for SRY (show SRY Proteins)-related high-mobility group box (show SSRP1 Proteins) 11 (SOX-11 (show SOX11 Proteins)), transcription factor E3 (TFE3) and beta-catenin (show CTNNB1 Proteins) on cell blocks.

  10. results reveal that PRCC (show PRCC Proteins)-TFE3 dual-fusion FISH probe is an efficient and concise technique for diagnosing PRCC (show PRCC Proteins)-TFE3 RCC (show XRCC1 Proteins) in paraffin-embedded tissue

Mouse (Murine) Transcription Factor E3 (TFE3) interaction partners

  1. TFEB (show TFEB Proteins) and TFE3 collaborate with each other in activated macrophages and microglia to promote efficient autophagy induction, increased lysosomal biogenesis, and transcriptional upregulation of numerous proinflammatory cytokines

  2. These data indicate that TFE3 and TFEB (show TFEB Proteins) play a cooperative, rather than redundant, role in the control of the adaptive response of whole-body metabolism to environmental cues such as diet and physical exercise.

  3. Findings indicated that TFE3 was an important hypoxia-induced transcriptional factor in HNSCC.

  4. Tfe3 and Tfeb (show TFEB Proteins) are required for the induced expression of Ppargamma2 (show PPARG Proteins) and subsequently for adipogenic genes.

  5. Tfe3 overexpression in HSPCs impaired long-term hematopoietic reconstitution in vivo, recapitulating the Flcn (show FLCN Proteins) KO phenotype, and supporting the notion that abnormal activation of Tfe3 contributes to the Flcn (show FLCN Proteins) KO phenotype. Flcn (show FLCN Proteins) KO mice develop an acute histiocytic hyperplasia in multiple organs, suggesting a novel function for Flcn (show FLCN Proteins) in macrophage development

  6. TFEB (show TFEB Proteins) and TFE3 are novel components of the integrated stress response

  7. Tfe3 is a critical transcription factor that regulates Pgc-1alpha gene expression in myotubes

  8. A conditional expression in mice of the fusion gene ASPSCR1 (show ASPSCR1 Proteins)-TFE3 from human alveolar soft part sarcoma (ASPS (show DARS Proteins)) generated a model that recapitulates the human tumor histologically and by expression profile.

  9. Data from transgenic mice suggest Tfe3 controls lipid metabolism in adipose tissue (white, WAT; brown, BAT (show BAAT Proteins)); TFE3 appears to be regulated by diet; up-regulation of TFE3 may inhibit expression of lipolysis genes in WAT and thermogenesis genes in BAT (show BAAT Proteins).

  10. These findings indicated that TFE3 has a regulatory role in myoblast differentiation, and that transcriptional suppression of myogenin (show MYOG Proteins) expression may be part of the mechanism of action.

TFE3 Protein Profile

Protein Summary

The microphthalmia transcription factor/transcription factor E (MITF-TFE) family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors includes four family members: MITF, TFE3, TFEB and TFEC. The TEF3 protein encoded by this gene activates transcription through binding to the muE3 motif of the immunoglobulin heavy-chain enhancer. The TFEC protein forms heterodimers with the TEF3 protein and inhibits TFE3-dependent transcription activation. The TEF3 protein interacts with transcription regulators such as E2F3, SMAD3, and LEF-1, and is involved in TGF-beta-induced transcription, playing important roles in cell growth, proliferation, and osteoclast and macrophage differentiation. The TFE3 protein also activates hepatic IRS-2 gene, and induces hexokinase II (HK2) and insulin-induced gene 1 (INSIG1)\; it participates in insulin signaling and could be a therapeutic target for diabetes. This gene is also involved in chromosomal translocations, resulting in different fusion gene products in papillary renal cell carcinomas and alveolar soft part sarcomas, such as PRCC-TFE3, RCC17-TFE3, PSF-TFE3, NonO (p54nrb)-TFE3 and ASPL-TFE3.

Gene names and symbols associated with Transcription Factor E3 Proteins (TFE3)

  • transcription factor binding to IGHM enhancer 3 (TFE3)
  • transcription factor E3 (Tfe3)
  • transcription factor binding to IGHM enhancer 3 (Tfe3)
  • transcription factor binding to IGHM enhancer 3 S homeolog (tfe3.S)
  • transcription factor binding to IGHM enhancer 3a (tfe3a)
  • bHLHe33 protein
  • cb873 protein
  • F830016E06Rik protein
  • RCCP2 protein
  • RCCX1 protein
  • RGD1559642 protein
  • Tcfe3 protein
  • Tfe-3 protein
  • TFEA protein
  • zgc:109815 protein

Protein level used designations for Transcription Factor E3 Proteins (TFE3)

class E basic helix-loop-helix protein 33 , transcription factor E family, member A , transcription factor E3 , transcription factor for IgH enhancer , transcription factor for immunoglobulin heavy-chain enhancer 3

GENE ID SPECIES
7030 Homo sapiens
209446 Mus musculus
317376 Rattus norvegicus
495043 Xenopus laevis
491872 Canis lupus familiaris
520800 Bos taurus
114834 Danio rerio
100346824 Oryctolagus cuniculus
100051983 Equus caballus
100511298 Sus scrofa
100733366 Cavia porcellus
101106403 Ovis aries musimon
Selected quality suppliers for TFE3 Proteins (TFE3)
Did you look for something else?