Transcription Factor E3 Proteins (TFE3)

The microphthalmia transcription factor/transcription factor E (MITF-TFE) family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors includes four family members: MITF, TFE3, TFEB and TFEC. Additionally we are shipping TFE3 Antibodies (113) and TFE3 Kits (7) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TFE3 7030 P19532
TFE3 209446 Q64092
Rat TFE3 TFE3 317376  
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Top TFE3 Proteins at antibodies-online.com

Showing 6 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$9,626.73
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Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$9,626.73
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Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
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Insect cells (Sf9) Human His tag Validation with Western Blot 20 μg Log in to see Available
$504.90
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
$814.00
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Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 11 to 18 Days
$582.75
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TFE3 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
, ,
Mouse (Murine)

More Proteins for Transcription Factor E3 (TFE3) Interaction Partners

Human Transcription Factor E3 (TFE3) interaction partners

  1. TFE3 gene rearrangement is associated with Epithelioid Rich Perivascular Epithelioid Cell Neoplasm of the Bladder.

  2. The data reveal that 4E-BP3 expression is controlled by the transcription factor TFE3 through a cis-regulatory element in the EIF4EBP3 gene promoter.

  3. Both SOX11 and TFE3 were overexpressed in solid-pseudopapillary neoplasms (SPNs) and may be involved in the pathogenesis.

  4. A Potential G-quadruplex-forming Sequence (PQS) in the intron 2 of the TFE3 gene suggested by in silico studies was confirmed. Increased and decreased formation of G-quadruplex occurred in presence of pyridostatin and antisense oligonucleotide respectively. Stable G-quadruplex formation affected biological processes and TFE3 splicing. G-quadruplex is behind TFE3 induced oncogenesis via translocation and mRNA splicing.

  5. TFE3 may promote renal tumor growth by regulating cell cycle progression and activating the phosphatidylinositol 3kinase/AKT serine/threonine kinase 1/mTOR signaling pathway.

  6. We report for the first time the presence of both TFE3 translocation and SDHB mutation in the same renal cell carcinoma tumor.

  7. TFEB and TFE3 collaborate with each other in activated macrophages and microglia to promote efficient autophagy induction, increased lysosomal biogenesis, and transcriptional upregulation of numerous proinflammatory cytokines

  8. Findings indicated that TFE3 was an important hypoxia-induced transcriptional factor in HNSCC.

  9. Solid pseudopapillary neoplasms (SPNs) showed positive staining for SRY-related high-mobility group box 11 (SOX-11), transcription factor E3 (TFE3) and beta-catenin on cell blocks.

  10. results reveal that PRCC-TFE3 dual-fusion FISH probe is an efficient and concise technique for diagnosing PRCC-TFE3 RCC in paraffin-embedded tissue

  11. Case Report: Melanotic Xp11 renal cell carcinoma with ARID1B-TFE3 gene fusion.

  12. Studies identified TFEB and TFE3 as master modulators of stress response notably in the lysosomal biogenesis and autophagy with capability to upregulate hundreds of genes involved in intracellular clearance, catabolism, metabolic processes, and cellular homeostasis.

  13. Ovarian sclerosing stromal tumor strongly overexpress TFE3.

  14. Describe the unusual morphology and expanded the morphologic spectrum of SFPQ/PSF-TFE3 renal cell carcinomas.

  15. Despite TFE3 over expression, TFE3 genetic alterations are less likely to be a major molecular event driving tumorigenesis in hepatic angiolipomas.

  16. we analyze 60 Xp11 translocation cancers by fluorescence in situ hybridization using custom bacterial artificial chromosome probes to establish their TFE3 fusion gene partner

  17. These results show that ASPL-TFE3 regulates cell cycle progression and induces cellular senescence by up-regulating p21 expression.

  18. RBM10-TFE3 is a recurrent gene fusion in Xp11 translocation renal cell carcinoma.

  19. Case Report: melanotic PEComa of the sinonasal mucosa with NONO-TFE3 fusion.

  20. Xp11 translocation renal cell carcinomas with RBM10-TFE3 gene fusion demonstrating melanotic features and overlapping morphology with t(6;11) RCC.

Mouse (Murine) Transcription Factor E3 (TFE3) interaction partners

  1. TFEB and TFE3 collaborate with each other in activated macrophages and microglia to promote efficient autophagy induction, increased lysosomal biogenesis, and transcriptional upregulation of numerous proinflammatory cytokines

  2. These data indicate that TFE3 and TFEB play a cooperative, rather than redundant, role in the control of the adaptive response of whole-body metabolism to environmental cues such as diet and physical exercise.

  3. Findings indicated that TFE3 was an important hypoxia-induced transcriptional factor in HNSCC.

  4. Tfe3 and Tfeb are required for the induced expression of Ppargamma2 and subsequently for adipogenic genes.

  5. Tfe3 overexpression in HSPCs impaired long-term hematopoietic reconstitution in vivo, recapitulating the Flcn KO phenotype, and supporting the notion that abnormal activation of Tfe3 contributes to the Flcn KO phenotype. Flcn KO mice develop an acute histiocytic hyperplasia in multiple organs, suggesting a novel function for Flcn in macrophage development

  6. TFEB and TFE3 are novel components of the integrated stress response

  7. Tfe3 is a critical transcription factor that regulates Pgc-1alpha gene expression in myotubes

  8. A conditional expression in mice of the fusion gene ASPSCR1-TFE3 from human alveolar soft part sarcoma (ASPS) generated a model that recapitulates the human tumor histologically and by expression profile.

  9. Data from transgenic mice suggest Tfe3 controls lipid metabolism in adipose tissue (white, WAT; brown, BAT); TFE3 appears to be regulated by diet; up-regulation of TFE3 may inhibit expression of lipolysis genes in WAT and thermogenesis genes in BAT.

  10. These findings indicated that TFE3 has a regulatory role in myoblast differentiation, and that transcriptional suppression of myogenin expression may be part of the mechanism of action.

  11. Machinery regulating exit of embryonic stem cells from pluripotency is ill defined; Flcn with its interaction partners Fnip1 and Fnip2 drives differentiation by restricting nuclear localization and activity of the bHLH transcription factor Tfe3.

  12. a major regulator of mast cell-mediated allergic response

  13. TFE3 and Galpha(16) are up-regulated under pathologic conditions and are involved in a novel mechanism of transcriptional regulation via the relocalization and activation of Galpha(16).

  14. FLCN tumor suppressor gene inactivation induces TFE3 transcriptional activity by increasing its nuclear localization

  15. TFE3 and TFEB regulate E-cadherin and WT1 expression

  16. IRS2, HK2 and INSIG1 are direct targets of TFE3

  17. Maximum Cd40lg promoter activity and gene expression required TFE3 or TFEB.

TFE3 Protein Profile

Protein Summary

The microphthalmia transcription factor/transcription factor E (MITF-TFE) family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors includes four family members: MITF, TFE3, TFEB and TFEC. The TEF3 protein encoded by this gene activates transcription through binding to the muE3 motif of the immunoglobulin heavy-chain enhancer. The TFEC protein forms heterodimers with the TEF3 protein and inhibits TFE3-dependent transcription activation. The TEF3 protein interacts with transcription regulators such as E2F3, SMAD3, and LEF-1, and is involved in TGF-beta-induced transcription, playing important roles in cell growth, proliferation, and osteoclast and macrophage differentiation. The TFE3 protein also activates hepatic IRS-2 gene, and induces hexokinase II (HK2) and insulin-induced gene 1 (INSIG1)\; it participates in insulin signaling and could be a therapeutic target for diabetes. This gene is also involved in chromosomal translocations, resulting in different fusion gene products in papillary renal cell carcinomas and alveolar soft part sarcomas, such as PRCC-TFE3, RCC17-TFE3, PSF-TFE3, NonO (p54nrb)-TFE3 and ASPL-TFE3.

Gene names and symbols associated with Transcription Factor E3 Proteins (TFE3)

  • transcription factor binding to IGHM enhancer 3 (TFE3)
  • transcription factor E3 (Tfe3)
  • transcription factor binding to IGHM enhancer 3 (Tfe3)
  • transcription factor binding to IGHM enhancer 3 S homeolog (tfe3.S)
  • transcription factor binding to IGHM enhancer 3a (tfe3a)
  • bHLHe33 protein
  • cb873 protein
  • F830016E06Rik protein
  • RCCP2 protein
  • RCCX1 protein
  • RGD1559642 protein
  • Tcfe3 protein
  • Tfe-3 protein
  • TFEA protein
  • zgc:109815 protein

Protein level used designations for Transcription Factor E3 Proteins (TFE3)

class E basic helix-loop-helix protein 33 , transcription factor E family, member A , transcription factor E3 , transcription factor for IgH enhancer , transcription factor for immunoglobulin heavy-chain enhancer 3

GENE ID SPECIES
7030 Homo sapiens
209446 Mus musculus
317376 Rattus norvegicus
495043 Xenopus laevis
491872 Canis lupus familiaris
520800 Bos taurus
114834 Danio rerio
100346824 Oryctolagus cuniculus
100051983 Equus caballus
100511298 Sus scrofa
100733366 Cavia porcellus
101106403 Ovis aries musimon
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