Transgelin Proteins (TAGLN)

The protein encoded by TAGLN is a transformation and shape-change sensitive actin cross-linking/gelling protein found in fibroblasts and smooth muscle. Additionally we are shipping Transgelin Antibodies (184) and Transgelin Kits (23) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TAGLN 6876 Q01995
TAGLN 21345 P37804
TAGLN 25123 P31232
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Top Transgelin Proteins at antibodies-online.com

Showing 10 out of 16 products:

Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 30 to 35 Days
$5,370.21
Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 30 to 35 Days
$5,370.21
Details
Escherichia coli (E. coli) Human GST tag Transgelin (TAGLN) (AA 2-201), (full length) protein (GST tag) 1 mg 60 to 71 Days
$1,842.50
Details
Escherichia coli (E. coli) Human His tag 100 μg 15 to 19 Days
$519.23
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg 11 Days
$888.80
Details
Wheat germ Human GST tag 10 μg 11 to 12 Days
$414.29
Details
Yeast Chicken His tag   1 mg 60 to 71 Days
$2,482.33
Details
Yeast Rat His tag   1 mg 60 to 71 Days
$2,486.00
Details
Yeast Cow His tag   1 mg 60 to 71 Days
$2,486.00
Details
Escherichia coli (E. coli) Human His tag   1 mg 2 to 3 Days
$3,055.38
Details

TAGLN Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, , ,
Mouse (Murine)

Rat (Rattus) ,

More Proteins for Transgelin (TAGLN) Interaction Partners

Human Transgelin (TAGLN) interaction partners

  1. SM22 is released into the circulation upon severe ischemia of the intestinal muscle layers. Patients with transmural intestinal ischemia had significantly higher plasma SM22 levels than patients with only ischemic mucosal injury, other acute abdominal diseases, or healthy controls.

  2. SM22 plays a role in regulating the transitions and morphological appearance of bacterially generated actin-rich structures during infections.

  3. transgelin-1 interacts with actin stress fibers and podosomes in smooth muscle cells via its type-3 CH-domain, while CLIK23 is dispensable for the binding to the actin structures

  4. High expression level of TAGLN is associated with prostate cancer.

  5. this study identified potential biochemical players involved in distant recurrence and indicates that R-Ras and Transgelin are potential post-surgical prognostic biomarkers for Stage III colorectal cancer

  6. During transition from the pluripotent stage towards the neural developmental stage, TAGLN is differentially expressed in bipolar patient derived cells compared to control derived cells.

  7. Data (including data from studies using cells cultured from transgenic/knockout mice) suggest that expression and degradation of transgelin in myofibroblasts and keratinocytes are regulated by mechanical tension in cytoskeleton produced by myosin II motor in response to stiffness of culture matrix/extracellular matrix.

  8. transgelin (TAGLN), a transforming growth factor beta (TGFbeta)-inducible gene, was identified as an upregulated gene during in vitro osteoblastic and adipocytic differentiation of human bone marrow-derived stromal (skeletal) stem cells

  9. Smooth muscle 22 regulates the proliferation of aortic smooth muscle cells participates in the development of thoracic aortic dissection.

  10. regulates vasculogenic mimicry in breast cancer cells by enhancing interleukin-8 uptake

  11. Serum concentrations of CK-18 fragments and transgelin-2 correlate with the severity of NAFLD, but not with obesity.

  12. Increases or decreases in transgelin levels have reciprocal effects on tumor cell behavior, with higher expression promoting metastasis

  13. activated AKT and JNK signaling pathways promote the overexpression of transgelin

  14. Cofilin-1 and transgelin may play roles in the carcinogenesis and development of esophageal squamous cell carcinoma

  15. Both tissue and salivary transgelin mRNA were closely correlated with various important clinicopathological parameters and were independent prognosis factors for oral squamous cell carcinoma.

  16. SM22alpha is a phosphorylation-regulated suppressor of IKK-IkappaBalpha-NF-kappaB signaling cascades.

  17. EZH2 regulates the chromatin structure at the TAGLN promoter through tri-methylation of H3K27, acting as an epigenetic integrator of IL-1beta and TGFbeta2 signaling.

  18. Transgelin may be an excellent diagnostic marker of Triple negative tumors and could be useful in stratification of patients

  19. Results indicate that miR-144 may regulate osteosarcoma cell proliferation and invasion by downregulating its target gene, transgelin protein (TAGLN), suggesting that miR-144 may be a potential therapeutic target for the treatment of osteosarcoma.

  20. TAGLN was highly expressed in NF1-deficient malignant peripheral nerve sheath tumors compared to NF1-deficient plexiform neurofibromas. Upregulation was caused by increased transcriptional expression. The TAGLN gene was hypomethylated in the MPNST cells.

Mouse (Murine) Transgelin (TAGLN) interaction partners

  1. Smooth muscle protein 22-alpha promoter-driven insulin-like growth factor 1 receptor deficiency promotes the formation of atherosclerotic plaque.

  2. Salvianolic acid A targeting the transgelin-actin complex to enhance vasoconstriction.

  3. CKII-SIRT1-SM22alpha acts in a loop to reinforce the expression of SM22alpha, which limits the inflammatory response in vascular smooth muscle cells.

  4. findings reveal for the first time that SM22 is expressed in the nucleus in addition to the cytoplasm of VSMCs to regulate the transcription of Nik and its downstream proinflammatory NF-kB signal pathways as a modulator of SRF during vascular inflammation

  5. The disruption of SM22alpha enhances PDGF-BB-induced GLUT4 translocation and glucose uptake by promoting actin dynamics and cortical actin polymeriza- tion.

  6. Data (including data from studies using cells cultured from transgenic/knockout mice) suggest that expression and degradation of transgelin in myofibroblasts and keratinocytes are regulated by mechanical tension in cytoskeleton produced by myosin II motor in response to stiffness of culture matrix/extracellular matrix.

  7. Targeted elimination of TGFbetaR2 in TAGLN(+) cells impairs midline closure and prevents the correct subsequent patterning of the musculature and skeletal components.

  8. SM22alpha is a phosphorylation-regulated suppressor of IKK-IkappaBalpha-NF-kappaB signaling cascades.

  9. SM22alpha promotes ubiquitination and degradation of MKP3. SM22alpha facilitates AngII-induced contraction by maintenance of ERK1/2 signaling.

  10. TRAF6-SM22alpha-G6PD pathway is a novel mechanism underlying the association between glucose metabolism and VSMC survival, which is beneficial for vascular repair after injury but facilitates atherosclerotic plaque stability.

  11. Absent/lower SM22 alpha levels favor an increase in parietal epithelial cell transition cells and PECs expressing a progenitor marker, and a lower epithelial mesenchymal transformation rate versus SM22alpha+/+mice, where SM22 levels are increased in PECs.

  12. SM22alpha-regulated molecular pathways contribute to vascular pathology.

  13. Histological analysis did not reveal calcium deposits in the aortic roots of SM22alpha-Rankl ( tg ) mice

  14. Data show that formation of a Krupple-like factor KLF4, pELK-1, and histone de-acetylase 2 (HDAC2) multiprotein complex dependent on the SM22alpha G/C Repressor element.

  15. Data suggest that SM22alpha expression in renal tissues might be a hallmark of kidney diseases.

  16. We conclude that the de novo expression of SM22alpha in glomerular epithelial cells affects the course of crescentic glomerulonephritis.

  17. critical role for the Tsc1/Tsc2-mTORC1-S6K axis in the normal development of cardiovascular tissue

  18. SM22 downregulation can induce proinflammatory vascular smooth muscle cells through activation of ROS-mediated NF-kappaB pathways.

  19. The effects of dichloroacetate treatment on pulmonary artery smooth muscle cells and pulmonary hypertension in mice with SM22alpha-targeted overexpression of the serotonin transporter are reported.

  20. loss of transgelin gene expression may be an important early event in tumor progression and a diagnostic marker for breast and colon cancer development.

Transgelin (TAGLN) Protein Profile

Protein Summary

The protein encoded by this gene is a transformation and shape-change sensitive actin cross-linking/gelling protein found in fibroblasts and smooth muscle. Its expression is down-regulated in many cell lines, and this down-regulation may be an early and sensitive marker for the onset of transformation. A functional role of this protein is unclear. Two transcript variants encoding the same protein have been found for this gene.

Gene names and symbols associated with Transgelin Proteins (TAGLN)

  • transgelin L homeolog (tagln.L)
  • transgelin (tagln)
  • transgelin (LOC732906)
  • transgelin (TAGLN)
  • transgelin (tagl)
  • transgelin (LOC100009332)
  • transgelin (Tagln)
  • MGC68550 protein
  • MGC107855 protein
  • Sm22 protein
  • SM22A protein
  • SMCC protein
  • TAGLN1 protein
  • WS3-10 protein
  • Ws310 protein
  • zgc:153186 protein

Protein level used designations for Transgelin Proteins (TAGLN)

transgelin , putative transgelin , 22 kDa actin-binding protein , SM22-alpha , smooth muscle protein 22-alpha , transgelin variant 2 , SM22 , Sm22alpha , actin-associated protein p27 , smooth muscle 22 protein , 25 kDa F-actin-binding protein , sm22 , sm22alpha-b

GENE ID SPECIES
399014 Xenopus laevis
594967 Xenopus (Silurana) tropicalis
732906 Bombyx mori
100189993 Taeniopygia guttata
100528947 Ictalurus punctatus
6876 Homo sapiens
100009332 Oryctolagus cuniculus
21345 Mus musculus
25123 Rattus norvegicus
479424 Canis lupus familiaris
513463 Bos taurus
396490 Gallus gallus
397021 Sus scrofa
751758 Danio rerio
100728822 Cavia porcellus
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