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TRPC4 encodes a member of the canonical subfamily of transient receptor potential cation channels.
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Mammalian Monoclonal TRPC4 Primary Antibody for ISt, IHC - ABIN1305021
Kurahara, Sumiyoshi, Aoyagi, Hiraishi, Nakajima, Nakagawa, Hu, Inoue: Intestinal myofibroblast TRPC6 channel may contribute to stenotic fibrosis in Crohn's disease. in Inflammatory bowel diseases 2015
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Rat (Rattus) Polyclonal TRPC4 Primary Antibody for ELISA, WB - ABIN451705
Song, Zhao, Narcisse, Duffy, Kress, Lee, Brosnan: Canonical transient receptor potential channel 4 (TRPC4) co-localizes with the scaffolding protein ZO-1 in human fetal astrocytes in culture. in Glia 2004
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Our results suggest that OGR1 (show GPR68 Antibodies)-dependent increases in TRPC4 expression may favor formation of highly Ca(2 (show CA2 Antibodies)+) -permeable TRPC4-containing channels that promote transformed granule cell migration. Increased motility of cancer cells is a prerequisite for cancer invasion and metastasis, and our findings may point towards a key role for TRPC4 in progression of certain types of medullablastoma.
Protein levels of TRPC4 were elevated in FCD II and tuberous sclerosis complex cortical samples compared to those of control samples.
STIM1L (show STIM1 Antibodies) and TRPC1 (show TRPC1 Antibodies)/4 are working together in myotubes to ensure efficient store refilling and a proper differentiation program.
These findings suggest identification of an important experimental tool compound, which has much higher potency for inhibiting TRPC1 (show TRPC1 Antibodies)/4/5 channels than previously reported agents, impressive specificity, and graded subtype selectivity within the TRPC1 (show TRPC1 Antibodies)/4/5 channel family.
silencing of TRPC4 alleviates angiogenesis induced by oxidized low-density lipoprotein in human coronary artery endothelial cells through inactivation of VEGF (show VEGFA Antibodies) and NF-kappaB (show NFKB1 Antibodies).
slow phase of Gi/o-mediated TRPC4 activation was diminished by inhibiting RhoA (show RHOA Antibodies) or enhancing PLCdelta function
Studies indicate potential roles for Rasd1 (show RASD1 Antibodies) small G protein (show RAC2 Antibodies) and leptin (show LEP Antibodies) in TRPC4 cation channel (show TRPV1 Antibodies) activation.
Galpha (show SUCLG1 Antibodies)(i2) activates the TRPC4 channel by direct binding.
This study identifies a novel role for TRPC4 in the regulation of autophagy in vascular endothelial cells.
The higher amplitude of store-operated Ca2 (show CA2 Antibodies)+ entry was associated to the over-expression for Stim2 (show Stim2 Antibodies), Orai2 (show ORAI2 Antibodies)-3, and TRPC1 (show TRPC1 Antibodies) while Stim2 (show Stim2 Antibodies) levels remained constant and Stim1 (show STIM1 Antibodies), Orai1 (show ORAI1 Antibodies), Orai3 (show ORAI3 Antibodies), TRPC1 (show TRPC1 Antibodies) and TRPC4 proteins were over-expressed in primary myelofibrosis.
These results indicate the contribution of heteromultimeric channels from TRPC1 (show TRPC1 Antibodies), TRPC4, and TRPC5 (show TRPC5 Antibodies) subunits to the regulation of mechanisms underlying spatial working memory and flexible relearning by facilitating proper synaptic transmission in hippocampal neurons.
the antidepressant and anxiolytic-like effects of a newly identified TRPC4/C5 inhibitor, M084.
TRPC4 knockdownsuppressed the activation of ERK (show EPHB2 Antibodies), p38 MAPK (show MAPK14 Antibodies) and AKT (show AKT1 Antibodies) signalingpathway.
Tarbp2 (show TARBP2 Antibodies) binding to TRPC4 promotes changes of cytosolic Ca(2 (show CA2 Antibodies)+) and, thereby, leads to a dynamic regulation of Dicer (show DICER1 Antibodies) activity, essentially at low endogenous Dicer (show DICER1 Antibodies) concentrations.
Changes in ion selectivity and pore dilation of the TRPC4 channel elicited by the Galphai2 (show GNAI2 Antibodies) subunit, were studied.
Constitutive ablation of TRPC4 in the amygdala is associated with diminished anxiety levels.
Data suggest that TRPC1 (show TRPC1 Antibodies) and TRPC4 are involved in the sprouting of sensory neurons following bladder cystitis, which leads to overactive bladder disease.
Data indicate that kisspeptin activates TRPC4 channels through PIP(2) depletion and cSrc tyrosine kinase activation in GnRH neurons.
the S4-S5 linker is a critical constituent of TRPC4/C5 channel gating and that disturbance of its sequence allows channel opening independent of any sensor domain.
The results of this study suggested that TRPC4, TRPM4 (show TRPM4 Antibodies), TRPM8 (show TRPM8 Antibodies) and TRPV1 (show TRPV1 Antibodies), showed statistically significant variation in mRNA levels between DRGs from different segments, suggesting ganglion-specific regulation of TRP (show TYRP1 Antibodies) channel gene expression.
This gene encodes a member of the canonical subfamily of transient receptor potential cation channels. The encoded protein forms a non-selective calcium-permeable cation channel that is activated by Gq-coupled receptors and tyrosine kinases, and plays a role in multiple processes including endothelial permeability, vasodilation, neurotransmitter release and cell proliferation. Single nucleotide polymorphisms in this gene may be associated with generalized epilepsy with photosensitivity. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
transient receptor potential 4
, transient receptor potential cation channel, subfamily C, member 5
, transient receptor potential cation channel, subfamily C, member 4
, short transient receptor potential channel 4-like
, short transient receptor potential channel 4
, trp-related protein 4
, capacitative calcium entry channel Trp4
, putative capacitative calcium entry channel
, receptor-activated cation channel TRP4
, transient receptor protein 4
, capacitative calcium entry channel 1
, transient receptor potential channel 4
, transient receptor potential protein 4
, transient receptor potential cation channel TRPC4 middle region 2