Transient Receptor Potential Cation Channel, Subfamily M, Member 8 Proteins (TRPM8)

Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Additionally we are shipping TRPM8 Antibodies (175) and TRPM8 Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TRPM8 79054 Q7Z2W7
TRPM8 171382 Q8R4D5
TRPM8 171384 Q8R455
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Top TRPM8 Proteins at antibodies-online.com

Showing 6 out of 10 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$5,370.21
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,749.58
Details
Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$5,370.21
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,749.58
Details
Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 11 to 18 Days
$582.75
Details
Escherichia coli (E. coli) Mouse Un-conjugated   5 applications Log in to see 1 to 2 Days
$318.85
Details

TRPM8 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
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Mouse (Murine) ,
,
Rat (Rattus)

More Proteins for Transient Receptor Potential Cation Channel, Subfamily M, Member 8 (TRPM8) Interaction Partners

Guinea Pig Transient Receptor Potential Cation Channel, Subfamily M, Member 8 (TRPM8) interaction partners

  1. The role of TRPM8 in the Guinea-pig bladder-cooling reflex investigated using a novel TRPM8 antagonist

Human Transient Receptor Potential Cation Channel, Subfamily M, Member 8 (TRPM8) interaction partners

  1. Study shows the cloning and characterization of N-terminal truncated TRPM8 isoforms in prostate epithelial cells and tumors. These isoforms exhibit likely 4TM domain structure which is distinct from the 6-TM of the TRP channel archetype. MTRPM8 isoforms act as the ER Ca2+-release channels not only in epidermis but also in prostate epithelial cells.

  2. The present data suggest a possible theoretical foundation for the anti-inflammatory role of TRPM8 activation, providing an experimental basis that could contribute to the advancement of cooling therapy for trauma patients.

  3. Study shows that TRPM8 expression is significantly up-regulated in pancreatic cancer.

  4. Data show evidence of recent local ambient temperature adaptation on the cation channel TRPM8.

  5. TRPM8 levels may be elevated in basal breast cancers, however, TRPM8 expression appears to be lost in many breast cancer cell lines

  6. In this study, we identify non-channel cytoplasmic small TRPM8 isoforms as putative regulator of PCa cell death

  7. Praziquantel is a relatively potent and selective partial agonist of the mammalian and avian cold and menthol receptor TRPM8.

  8. The TRPM8 transient receptor potential channel.

  9. our results indicate that enhanced TRPM8 hydrolysis in prostate cancer could present an adaptation mechanism, sustained via bypassing testosterone-induced rapid Ca2+ uptake through TRPM8, thus, diminishing the rates of apoptosis

  10. Suggest a novel, pore-independent molecular mechanism by which endogenous TRPM8 expression inhibits Rap1 GTPase and thus plays a critical role in the behavior of vascular endothelial cells by inhibiting migration.

  11. in this study, the glycosylation status of the TRPM8 channel was shown to affect cell proliferation, cell migration, and calcium uptake. TRPM8 expressed in the membrane of the Panc-1 pancreatic tumoral cell line is non-glycosylated, whereas human embryonic kidney cells transfected with human TRPM8 overexpress a glycosylated protein.

  12. This study demonstrates that TRPM8 (cold receptor) is present in nasal epithelium. When it is activated by moderate cooling at 24 degrees C or menthol, TRPM8 induces the secretion of mucin. This study determines that TRPM8 channels are important regulators of mucin production. Therefore, TRPM8 antagonists could be used for the treatment of refractory rhinitis.

  13. This study suggests that the TRPM8 sensor is a key determinant of germ cell fate under hypothermic stimulation.

  14. TRPM8 SNPs are significantly associated with the risk of COPD in the Chinese Han population.

  15. findings demonstrate that both the eTRPM8 expression level and the modalities of cold-stimulation serve as important determinants of the keratinocyte fate and act via fine tuning of [ATP] and [O2*]

  16. TRPM8 activation is likely to occur when cigarettes contain more than 50 micrograms of menthol.

  17. This review outlines our current understanding on the role of TRPM8 in occurrence and development of different kinds of tumor and also includes discussion about the regulation of TRPM8 during carcinogenesis as well as therapeutic potential of targeting TRPM8 in tumor, which may be utilized for a potential pharmacological use as a target for anti-cancer therapy.[review]

  18. The effects of specific agents on TRPV1 and TRPM8 channels are intricately interrelated.

  19. The data of this study provided evidence for decreased activity and expression level of TRPM8 in the presence of methylglyoxal.

  20. Study used a combination of molecular modeling and experimental techniques to examine the structure of the TRPM8 transmembrane and pore helix region including the conducting conformation of the selectivity filter

Mouse (Murine) Transient Receptor Potential Cation Channel, Subfamily M, Member 8 (TRPM8) interaction partners

  1. Cold air could induce inflammatory responses through the TRPM8-mediated PKC/NF-kappaB signal pathway in primary airway epithelial cells of asthmatic mice.

  2. Data suggest that transient receptor potential melastatin 8 (TRPM8) may represent a novel therapeutic target for combating obstructive airway diseases, such as asthma.

  3. These results suggest that TRPM8 expressed in tissues apart from cutaneous sensory nerves are involved in autonomic thermoregulation response.

  4. Since disruption of the clock machinery has been associated with many metabolic disorders, the pharmacological modulation of TRPM8 channel may become a promising therapeutic target to counterbalance weight gain, through increased thermogenesis, energy expenditure, and clock gene activation.

  5. These results suggest that TRPV4, TRPV3 and TRPM8 proteins, but not their ion channel activities are necessary for the induction of CIPs at 32 degrees C. Identification of proteins that differentially interact with these TRP channels at 37 degrees C and 32 degrees C would help elucidate the underlying mechanisms of CIP induction by hypothermia.

  6. Praziquantel is a relatively potent and selective partial agonist of the mammalian and avian cold and menthol receptor TRPM8.

  7. These results taken together with other reports suggest that TRPM8 containing sensory neurons are environmental cooling detectors that may be nociceptive or non-nociceptive depending on the sensitivity of individual fibers to different combinations of stimulus modalities.

  8. TRPM8 activation by dietary menthol improves energy metabolism and exercise endurance, which are likely driven by TRPM8-mediated Ca2+-dependent upregulation of PGC1alpha and its target genes involved in the mitochondrial function.

  9. TRPM8 in macrophages determines pro- or anti-inflammatory actions by regulating tumor necrosis factor-alpha and interleukin-10 production. These findings suggest novel TRPM8-based options for immunomodulatory intervention.

  10. Here the authors show that AITC (allyl isothiocyanate; mustard oil) and menthol represent two distinct types of ligands at the mammalian cold sensor TRPM8.

  11. The results of this study show that chronic morphine upregulates TRPM8 channels, which is in contrast with the previous finding that acute morphine triggers TRPM8 internalization.

  12. data suggest that sex differences in the functioning of Ih and Ik in TRPM8 expressing primary afferent neurons leads to differences in cool temperature sensitivity

  13. This study suggests that the TRPM8 sensor is a key determinant of germ cell fate under hypothermic stimulation.

  14. We identify PLCdelta4 as a PLC isoform important in the regulation of TRPM8 both at the cellular level and in vivo

  15. This paper unveils the critical role of the brake potassium current IKD in damage-triggered cold allodynia.

  16. Reduced functional expression of TRPM8 in sensory neurons (due to VAMP7 knockout) is associated with deficits in cold avoidance and icilin-induced cold hypersensitivity.

  17. Report essential role of skin TRPM8 in a model of acute cold-induced urinary urgency.

  18. This study findings suggest the existence of VGLUT2 (but not VGLUT1)-mediated glutamate signaling in TRPM8+ neurons possibly underlying the cold-induced acute pain and hypersensitivity to cold following pulpal inflammation.

  19. Data suggest that blockage of transient receptor potential (TRP) channels TRPA1, TRPV4 and possibly TRPM8 may represent a therapeutic option for patients with colonic discomfort and pain.

  20. peripheral osmosensor responsible for the regulation of normal eye-blinking

TRPM8 Protein Profile

Protein Summary

Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonists menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing.

Gene names and symbols associated with TRPM8

  • transient receptor potential cation channel subfamily M member 8 (TRPM8)
  • transient receptor potential cation channel subfamily M member 8b L homeolog (trpm8b.L)
  • transient receptor potential cation channel subfamily M member 8 (Trpm8)
  • transient receptor potential cation channel, subfamily M, member 8 (Trpm8)
  • transient receptor potential cation channel, subfamily M, member 8 (TRPM8)
  • CMR1 protein
  • LTrpC-6 protein
  • LTRPC6 protein
  • Trp-p8 protein
  • TRPM8 protein
  • trpm8b protein
  • TRPP8 protein

Protein level used designations for TRPM8

transient receptor potential cation channel, subfamily M, member 8 , transient receptor potential cation channel subfamily M member 8b , transient receptor potential cation channel subfamily M member 8 , transient potential cation channel subfamily M member 8 , LTrpC-6 , long transient receptor potential channel 6 , short form of the TRPM8 cationic channel , transient receptor potential p8 , transient receptor potential subfamily M member 8 , trp-p8 , TRP ion channel TRPM8 , transient receptor potential-p8 , cold menthol receptor 1 , cold/menthol receptor 1 , menthol receptor , transient receptor potential M8 protein , transient receptor potential cation channel, subfamily M, member 8 (predicted), 3 prime , transient receptor potential cation channel, subfamily M, member 8 (predicted), 5 prime

GENE ID SPECIES
100137386 Papio anubis
100302012 Xenopus laevis
100337634 Cavia porcellus
79054 Homo sapiens
171382 Mus musculus
171384 Rattus norvegicus
424025 Gallus gallus
486170 Canis lupus familiaris
541151 Bos taurus
100328692 Oryctolagus cuniculus
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