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TSNAX encodes a protein which specifically interacts with translin, a DNA-binding protein that binds consensus sequences at breakpoint junctions of chromosomal translocations. Additionally we are shipping Translin-Associated Factor X Antibodies (39) and many more products for this protein.
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Translin (show TSN Proteins) and Trax control telomere-associated transcript levels in human cells in a telomere-specific fashion.
TSNAX protein is known to form a brain enriched complex with translin (show TSN Proteins), that can bind single-stranded DNA and RNA through which it is involved in protein regulation.
High chimeric TSNAX-DISC1 (show DISC1 Proteins) resulting from intergenic splicing is associated with endometrial carcinoma.
LIS1 and TSNAX genes are not associated with susceptibility to bipolar I disorder in Chinese Han population.
Data show a novel role of phospholipase Cbeta1 (PLCbeta1) in gene regulation through translin-associated factor X (TRAX) association.
Our results provide further evidence for sex-dependent effects of the TSNAX/DISC1 (show DISC1 Proteins) locus in the aetiology of schizophrenia and bipolar affective disorder
TRAX binds to ssDNA and two regions in TRAX, designated TRAXB2 and TRAXB3, mediate nucleic acid binding activity of the trax-translin (show TSN Proteins) heteromeric complex.
C3PO (show TSN Proteins) endonuclease is an asymmetric octamer barrel consisting of six translin (show TSN Proteins) and two TRAX subunits which activates RISC by degrading the Ago2 (show EIF2C2 Proteins)-nicked passenger strand of siRNA.
The results of this suggested an association between the TSNAX-DISC1 (show DISC1 Proteins) region and both forms of affective disorders.
Results suggest that rs766288 in translin-associated factor X gene may play a role in the pathophysiology of female major depressive disorder in the Japanese population.
TRAX is required for DNA repair, by interacting with activated ATM (show ATM Proteins) and protects cells from genotoxic stress-induced apoptosis.
trax acts to regulate translin's RNA and DNA binding affinities as part of a cellular RNA trafficking mechanism.
The TB-RBP (show TSN Proteins)-related and -interacting protein Translin-associated factor X was reduced to 50% normal levels in heterozygotes and was absent in TB-RBP (show TSN Proteins)-null animals.
TRAX is post-transcriptionally stabilized by TB-RBP (show TSN Proteins) and both proteins are needed for normal cell proliferation
subcellular locations of TB-RBP (show TSN Proteins) and TRAX in male germ cells are modulated by the relative ratios of TRAX and TB-RBP (show TSN Proteins)
Trax was found to accumulate in the Golgi complex of mid-late pachytene spermatocytes
This gene encodes a protein which specifically interacts with translin, a DNA-binding protein that binds consensus sequences at breakpoint junctions of chromosomal translocations. The encoded protein contains bipartite nuclear targeting sequences that may provide nuclear transport for translin, which lacks any nuclear targeting motifs.
translin-associated protein X
, translin-associated factor X
, translin-like protein