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Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. Additionally we are shipping Trefoil Factor 2 Antibodies (122) and Trefoil Factor 2 Kits (57) and many more products for this protein.
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Data show that trefoil factor 2 (TFF2( urine levels continuously decreased with disease progression, TFF2 serum concentrations progressively increased from the early to later chronic kidney disease (CKD) stages, indicating changes in renal function and offering the potential to examine the course of CKD.
this work reveals that TFF2 has tumor-suppressor activity, which may, in part, be regulated by SMAD4 (show SMAD4 Proteins).
Data indicate that the antitumor activity of trefoil factor 2 (TFF2) is mediated by an interaction with the transcription factor Sp3 (Sp3) in gastric cancer cells.
Data show the important functions of TFF2 in the gastric mucus barrier, mucus epithelia, immune system, central nervous system, and during fertilization. It has been shown to interact with the gastric mucin MUC6 (show MUC6 Proteins). [Review]
These findings suggest that the rs184432 and rs225359 polymorphisms in TFF1 (show TFF1 Proteins) have protective effects for GC and contribute to the development of GC in Korean individuals.
We reproducibly associate higher expression of the ligand-receptor axis of TFF2 and CXCR4 (show CXCR4 Proteins) with BRAF (show BRAF Proteins) V600E-mutant colon cancer
protease-activated receptor 4 (show F2RL3 Proteins) and Trefoil factor 2 are expressed in human colorectal cancer
The structural features of the N-linked N,N'-di-N-acetyllactosediamine-inducing determinant on human TFF2 are discussed.
Human TTF2 (show FOXE1 Proteins) is a lectin that binds alpha-GlcNAc-capped mucin 6 (show MUC6 Proteins) g with antibiotic activity against Helicobacter pylori.
Significantly higher levels of TFF2 were in patients with Multiple Organ Dysfunction Syndrome.
Low intestinal TFF2 expression was measured at early maturation stages. Weaning, however, was associated with a distinct response of increased TFF2 expression, indicating an important role in enhancing mucosal integrity.
the Tg(Tff1 (show TFF1 Proteins)-CreERT2;Tff2-rtTA;Tff3 (show TFF3 Proteins)-Luc) strain can confer intermittent transgene expression to gastric epithelial cells that have undergone previous gene modification, and may be suitable to genetically model therapeutic intervention during development, tumorigenesis, and other genetically tractable diseases
Splenic TFF2 is released by vagally modulated memory T cells to suppress expansion of myeloid-derived suppressor cells (MDSC) through CXCR4 (show CXCR4 Proteins). TFF2 is important to the anti-inflammatory reflex arc (show NOL3 Proteins) and has an essential role in arresting MDSC proliferation.
hnRNP A1 (show HNRNPA1 Proteins) improves intestinal injury in anti-CD3 (show CD3E Proteins) antibody-induced enteritis mice through the upregulation of TFF2, which regulates apoptosis and enhances epithelial restoration
Overexpressing Tff2 in cultured cells reduced doubling time in vitro and rapidly increased xenograft tumor size in vivo
Epithelial TFF2 is an important endogenous regulator of gut (show GUSB Proteins) mucosal homeostasis that can modulate immune and epithelial compartments.
The Tff2 gene is expressed in the hypothalamus and is regulated by food intake. Knockout mice are leaner (show CACNA1A Proteins) and have reduced fat mass compared to wild-type.
The increased expression of endogenous TFF2 in response to chronic allergic inflammation is insufficient to prevent the progression of airway inflammation and remodeling in a model of chronic allergic airways disease.
TFF2 functions as a regulator of intestinal homeostasis that suppresses Toxoplasma gondii-driven type 1 inflammation.
TFF2 (trefoil factor 2), an epithelial cell-derived repair molecule, is needed for the control of lung injury caused by the hookworm parasite Nippostrongylus brasiliensis and for type 2 immunity after infection.
results suggest that during retinal cell death periods, requiring a tightly regulated balance between cell survival and cell death, TFF2 acts pro-proliferative and pro-apoptotic at least in developing mouse retinae cultured in vivo
Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium. The encoded protein inhibits gastric acid secretion. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21.
trefoil factor 2
, trefoil factor 2 (spasmolytic protein 1)
, trefoil factor family peptide 2
, spasmolytic polypeptide
, spasmolytic protein 1
, pancreatic spasmolytic polypeptide
, spasmolytic peptide
, spasmolytic peptide 1
, spasmolytic polypeptide 1
, P-domain peptide
, TFF p4.1
, putative gastrointestinal growth factor xP4