anti-Triggering Receptor Expressed On Myeloid Cells 2 (TREM2) Antibodies

TREM2 encodes a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. Additionally we are shipping TREM2 Kits (31) and TREM2 Proteins (20) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
TREM2 54209 Q9NZC2
TREM2 83433 Q99NH8
TREM2 301227  
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Top anti-TREM2 Antibodies at antibodies-online.com

Showing 10 out of 196 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-TREM2 Antibody Titration:  0.2-1 ug/ml  Positive Control:  Human Muscle Host:  Rabbit  Target Name:  TREM2  Sample Tissue:  Human Jurkat Whole Cell  Antibody Dilution:  1ug/ml 100 μL Log in to see 2 to 3 Days
$319.00
Details
Human Goat Un-conjugated CyTOF, FACS, ICC, WB TREM-2 in Human Dendritic Cells. TREM-2 was detected in immersion fixed immature human dendritic cells using Goat Anti-Human TREM-2 Antigen Affinity-purified Polyclonal Antibody. Specific staining was localized to cytoplasm. Detection of Human TREM-2 by Western Blot. Western blot shows lysates of THP-1 human acute monocytic leukemia cell line. PVDF membrane was probed with 0.2 ug/mL of Goat Anti-Human TREM-2 Antigen Affinity-purified Polyclonal Antibody. This experiment was conducted under reducing conditions. 100 μg Log in to see 8 to 9 Days
$422.05
Details
Mouse Goat Un-conjugated ELISA, WB Antibody (1µg/ml) staining of  Mouse Spinal Cord lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 6 to 7 Days
$429.62
Details
Human Goat Un-conjugated ELISA, IHC   100 μg Log in to see 6 to 7 Days
$429.62
Details
Human Mouse Un-conjugated ELISA, SimWes, WB Simple Western: TREM-2 Antibody (2B5) [NBP1-07101] - Simple Western lane view shows a specific band for TREM-2 in 0.5 mg/ml of MCF-7 lysate. This experiment was performed under reducing conditions using the 12-230 kDa separation system. Western Blot: TREM-2 Antibody (2B5) [NBP1-07101] - Cell lysates of HeLa, MCF7, LNCaP and mouse brain (30ug) were resolved by SDS-PAGE, transferred to NC membrane and probed with anti-human TREM2 (1:500). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. 0.1 mL Log in to see 7 to 9 Days
$485.88
Details
Human Rat Un-conjugated CyTOF, FACS Detection of TREM-2 in THP-1 Human Cell Line by Flow Cytometry. THP-1 human acute monocytic leukemia cell line was stained with Rat Anti-Human/Mouse TREM-2 Monoclonal Antibody. Detection of TREM-2 in Human Mature Dendritic Cells by Flow Cytometry. Human mature dendritic cells were stained with Rat Anti-Human/Mouse TREM-2 Monoclonal Antibody. 100 μg Log in to see 8 to 9 Days
$328.90
Details
Human Rabbit Un-conjugated FACS, IF (p), IHC (p), WB Human colon carcinoma lysate 30ug, probed (ABIN749678) at 1:200 overnight in 4 °C. Followed by conjugation to the secondary antibody at 1:3000 90min in 37 °C. Predicted band size at 25 kDa, and observed band size at 30kDa. Formalin-fixed and paraffin embedded human gastritis labeled with Rabbit Anti TREM2 Polyclonal Antibody, Unconjugated (ABIN749678) at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL Log in to see 3 to 7 Days
$318.45
Details
Human Mouse Un-conjugated EIA, WB 0.1 mL Log in to see 6 to 8 Days
$412.50
Details
Mouse Goat Un-conjugated EIA, WB Sstaining of Mouse Liver lysate using Anti-TREM2 antibody at 0.3 µg/ml (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg Log in to see 6 to 8 Days
$390.50
Details
Human Rat APC FACS Detection of TREM-2 in RAW 264.7 Mouse Cell Line by Flow Cytometry. RAW 264.7 mouse monocyte/macrophage cell line was stained with Rat Anti-Human/Mouse TREM-2 APC-conjugated Monoclonal Antibody. Detection of TREM-2 in HEK Human Cell Line Transfected with Human TREM-2 and eGFP by Flow Cytometry. HEK293 human embryonic kidney cell line transfected with either (A) human TREM-2 or (B) human TREM-1 and eGFP was stained with Rat Anti-Human/Mouse TREM-2 APC-conjugated Monoclonal Antibody. 100 Tests Log in to see 8 to 9 Days
$427.80
Details

Top referenced anti-TREM2 Antibodies

  1. Human Polyclonal TREM2 Primary Antibody for CyTOF, FACS - ABIN4899382 : Quan, Cooper, Potter, Roberts, Cheng, Jarvis: TREM-2 binds to lipooligosaccharides of Neisseria gonorrhoeae and is expressed on reproductive tract epithelial cells. in Mucosal immunology 2008 (PubMed)
    Show all 9 Pubmed References

  2. Human Polyclonal TREM2 Primary Antibody for FACS, ICC - ABIN4899381 : Cooper-Knock, Green, Altschuler, Wei, Bury, Heath, Wyles, Gelsthorpe, Highley, Lorente-Pons, Beck, Doyle, Otero, Traynor, Kirby, Shaw, Hide: A data-driven approach links microglia to pathology and prognosis in amyotrophic lateral sclerosis. in Acta neuropathologica communications 2017 (PubMed)
    Show all 3 Pubmed References

  3. Human Monoclonal TREM2 Primary Antibody for FACS - ABIN4897941 : Hall, Agrawal: Increased TREM-2 expression on the subsets of CD11c+cells in the lungs and lymph nodes during allergic airway inflammation. in Scientific reports 2017 (PubMed)
    Show all 3 Pubmed References

  4. Human Monoclonal TREM2 Primary Antibody for CyTOF, FACS - ABIN4900550 : Wu, Byers, Jin, Agapov, Alexander-Brett, Patel, Cella, Gilfilan, Colonna, Kober, Brett, Holtzman: TREM-2 promotes macrophage survival and lung disease after respiratory viral infection. in The Journal of experimental medicine 2015 (PubMed)
    Show all 2 Pubmed References

  5. Human Monoclonal TREM2 Primary Antibody for ELISA, SimWes - ABIN449602 : Roussos, Katsel, Fam, Tan, Purohit, Haroutunian: The triggering receptor expressed on myeloid cells 2 (TREM2) is associated with enhanced inflammation, neuropathological lesions and increased risk for Alzheimer's dementia. in Alzheimer's & dementia : the journal of the Alzheimer's Association 2015 (PubMed)
    Show all 2 Pubmed References

  6. Mouse (Murine) Monoclonal TREM2 Primary Antibody for FACS - ABIN2476936 : Humphrey, Daws, Spusta, Niemi, Torchia, Lanier, Seaman, Nakamura: TREM2, a DAP12-associated receptor, regulates osteoclast differentiation and function. in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2006 (PubMed)

  7. Human Polyclonal TREM2 Primary Antibody for FACS, IF (p) - ABIN749678 : Satoh, Kawana, Yamamoto, Ishida, Saito, Arima: A survey of TREM2 antibodies reveals neuronal but not microglial staining in formalin-fixed paraffin-embedded postmortem Alzheimer's brain tissues. in Alzheimer's research & therapy 2014 (PubMed)

More Antibodies against TREM2 Interaction Partners

Human Triggering Receptor Expressed On Myeloid Cells 2 (TREM2) interaction partners

  1. Our data establish a critical link between oAbeta1-42, a major pathological component of Alzheimer's disease and TREM2

  2. Data indicate a novel role for PS1 (show PSEN1 Antibodies) in regulating TREM2 intracellular trafficking and pathophysiological function.

  3. Homozygous TREM2 R47C carrier presenting with an FTD (show FTL Antibodies) rather than an Alzheimer's disease phenotype.

  4. Our results suggest that deficiency of microglial TREM2 leads to heightened tau pathology coupled with widespread increases in activated neuronal stress kinases

  5. In the current study, we evaluated the rs75932628 polymorphism in the Chinese Han population. However, we did not detect any rs75932628-T in our cohort, indicating that the single nucleotide polymorphism of TREM2 may not be a genetic marker to assess the risk of LOAD in the Chinese Han population.

  6. TREM-2 promotes acquired cholesteatoma-induced bone destruction by modulating TLR4 (show TLR4 Antibodies) signaling pathway and osteoclasts activation

  7. ADAM17 (show ADAM17 Antibodies) is the main sheddase for the generation of human triggering receptor expressed in myeloid cells (hTREM2) ectodomain and cleaves TREM2 after Histidine 157. Findings reveal a link between shedding of TREM2 and its regulation during inflammatory conditions or chronic neurodegenerative disease in which activity or expression of sheddases might be altered.

  8. In rheumatoid arthritis (RA), the expression of TREM-2 was reduced at first and then up-regulated after stimulation by TNF-alpha (show TNF Antibodies). TREM-2 also inhibited the activation of TNF-alpha (show TNF Antibodies) induced of inflammation in RA-fibroblast-like synovial cells (FLSs) by the p38 (show CRK Antibodies) pathway.

  9. TREM2 is shed by proteases of the ADAM (a disintegrin and metalloproteinase domain containing protein) family C-terminal to histidine 157, a position where an AD-associated coding variant has been discovered (p.H157Y) in the Han Chinese population.

  10. Selective partial inhibition of cleavage of triggering receptor expressed on myeloid cells 2 TREM2 at H157-Ser158 bond might provide a potential therapeutic strategy for carriers of the Alzheimer's disease-associated H157Y variant and possibly for individuals with wild-type TREM2.

Mouse (Murine) Triggering Receptor Expressed On Myeloid Cells 2 (TREM2) interaction partners

  1. Our data establish a critical link between oAbeta1-42, a major pathological component of Alzheimer's disease and TREM2

  2. These data suggest that the Alzheimer's disease-associated TREM2 R47H variant increases risk for Alzheimer's disease by conferring a loss of TREM2 function and enhancing neuritic dystrophy around plaques.

  3. Data indicate a novel role for PS1 (show PSEN1 Antibodies) in regulating TREM2 intracellular trafficking and pathophysiological function.

  4. whereas complete TREM2 deficiency protected against tau-mediated microglial activation and atrophy, TREM2 haploinsufficiency elevated expression of proinflammatory markers and exacerbated atrophy at a late stage of disease. The differential effects of partial and complete loss of TREM2 on microglial function and tau pathology

  5. TREM2 plays a crucial role in altering the proinflammatory M1 microglia to M2 phenotype and has beneficial effects in the immune pathogenesis of Parkinson's disease.

  6. Overexpression of TREM2 downregulated the levels of IL-1beta (show IL1B Antibodies), ameliorated T396 expression, inhibited the activity of GSK-3beta, and improved sickness behavior. Increased Arg1 (show ARG1 Antibodies) expression and a high level of synaptophysin (show SYP Antibodies) were also observed in the transgenic mice following TREM2 overexpression.

  7. These studies of the role of TREM2 in neuroinflammation and neurodegeneration suggest that impairing microglial TREM2 signaling reduces pure tauopathy.

  8. This article suggests a potential explanation of why TREM2-deficient microglia are unable to respond to neurotoxic plaques in the Alzheimer's disease brain and highlight a further need to understand microglial biology.

  9. TREM2 protects against cerebral ischemia/reperfusion injury through the aspect of post-ischemic inflammatory response and neuronal apoptosis.

  10. Results suggest that TREM2 plays a critical role in inflammation and neuronal cell survival and in neurogenesis. Study showed that TREM2 is a soluble protein transported by macrophages through ventricle walls and choroid plexus, and then enters the brain parenchyma via radial glial cells. TREM2 protein is essential for neuroplasticity and myelination. A lack of TREM2 protein may accelerate aging.

TREM2 Antigen Profile

Protein Summary

This gene encodes a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. The encoded protein functions in immune response and may be involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene names and symbols associated with TREM2

  • triggering receptor expressed on myeloid cells 2 (TREM2) antibody
  • triggering receptor expressed on myeloid cells 2 (trem2) antibody
  • trem-like transcript 2 protein (LOC100228399) antibody
  • triggering receptor expressed on myeloid cells 2 (Trem2) antibody
  • TREM-2 antibody
  • TREM-A1 antibody
  • TREM-B1 antibody
  • TREM2 antibody
  • Trem2a antibody
  • Trem2b antibody
  • Trem2c antibody

Protein level used designations for TREM2

triggering receptor expressed on myeloid cells 2 , triggering receptor expressed on monocytes 2 , triggering receptor expressed on myeloid cells 2a , triggering receptor expressed on myeloid cells 2b , triggering receptor expressed on myeloid cells 2c

GENE ID SPECIES
419920 Gallus gallus
748470 Pan troglodytes
100126214 Xenopus (Silurana) tropicalis
100228399 Taeniopygia guttata
719740 Macaca mulatta
54209 Homo sapiens
83433 Mus musculus
301227 Rattus norvegicus
608965 Canis lupus familiaris
100737974 Sus scrofa
506467 Bos taurus
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