anti-Tripartite Motif Containing 24 (TRIM24) Antibodies

The protein encoded by TRIM24 mediates transcriptional control by interaction with the activation function 2 (AF2) region of several nuclear receptors, including the estrogen, retinoic acid, and vitamin D3 receptors. Additionally we are shipping TRIM24 Proteins (7) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
TRIM24 8805 O15164
TRIM24 21848 Q64127
TRIM24 500084  
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Top anti-TRIM24 Antibodies at

Showing 10 out of 131 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-TRIM24 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:62500  Positive Control:  Hela cell lysate TRIM24 is supported by BioGPS gene expression data to be expressed in HeLa 100 μL 2 to 3 Days
Cow Rabbit Un-conjugated WB WB Suggested Anti-TRIM24 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:62500  Positive Control:  PANC1 cell lysate 100 μL 2 to 3 Days
Human Goat Un-conjugated ELISA, IHC   100 μg 6 to 7 Days
Cow Rabbit Un-conjugated IHC, WB Immunohistochemical analysis of TIF1 alpha staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Western blot analysis of TIF1 alpha expression in MCF7 (A), HeLa (B) whole cell lysates. 200 μL 13 to 14 Days
Human Rabbit Un-conjugated ELISA, ICC, IF, IHC, WB ABIN6266699 at 1/100 staining human lymph node tissue sections by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary. Western blot analysis of extracts from various samples, using TRIM24 Antibody. Lane 1: 293 treated with blocking peptide. Lane 2: 293; Lane 3: hela; 100 μL 11 to 12 Days
Human Rabbit Un-conjugated IHC, ELISA, WB Western blot analysis of extracts from COLO cells, using TRIM24 Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human brain tissue, using TRIM24 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg 2 to 3 Days
Human Mouse Un-conjugated ELISA, IF, IHC, IHC (p), IP, WB 100 μg 11 to 14 Days
Human Rabbit Un-conjugated ELISA, IHC, WB Western Blot (WB) analysis of specific cells using TIF1alpha Polyclonal Antibody. 100 μL Available
Human Rabbit Un-conjugated ELISA, IHC, IHC (p), WB 50 μL 11 to 14 Days
Human Rabbit Un-conjugated WB 100 μL 11 to 14 Days

Top referenced anti-TRIM24 Antibodies

  1. Human Polyclonal TRIM24 Primary Antibody for IP, WB - ABIN251037 : Levin, Panchabhai, Shen, Kornblau, Qiu, Baggerly: Different changes in protein and phosphoprotein levels result from serum starvation of high-grade glioma and adenocarcinoma cell lines. in Journal of proteome research 2010 (PubMed)
    Show all 4 Pubmed References

  2. Human Monoclonal TRIM24 Primary Antibody for IF, IHC (p) - ABIN563797 : Kikuchi, Okumura, Tsukiyama, Watanabe, Miyajima, Tanaka, Imamura, Hatakeyama: TRIM24 mediates ligand-dependent activation of androgen receptor and is repressed by a bromodomain-containing protein, BRD7, in prostate cancer cells. in Biochimica et biophysica acta 2009 (PubMed)
    Show all 3 Pubmed References

  3. Human Polyclonal TRIM24 Primary Antibody for ICC, IF - ABIN251036 : Allton, Jain, Herz, Tsai, Jung, Qin, Bergmann, Johnson, Barton: Trim24 targets endogenous p53 for degradation. in Proceedings of the National Academy of Sciences of the United States of America 2009 (PubMed)
    Show all 3 Pubmed References

  4. Human Polyclonal TRIM24 Primary Antibody for IHC (p), IHC - ABIN268590 : Thénot, Henriquet, Rochefort, Cavaillès: Differential interaction of nuclear receptors with the putative human transcriptional coactivator hTIF1. in The Journal of biological chemistry 1997 (PubMed)

  5. Human Polyclonal TRIM24 Primary Antibody for ICC, IF - ABIN4359700 : Theurillat, Udeshi, Errington, Svinkina, Baca, Pop, Wild, Blattner, Groner, Rubin, Moch, Privé, Carr, Garraway: Prostate cancer. Ubiquitylome analysis identifies dysregulation of effector substrates in SPOP-mutant prostate cancer. in Science (New York, N.Y.) 2014 (PubMed)

More Antibodies against TRIM24 Interaction Partners

Human Tripartite Motif Containing 24 (TRIM24) interaction partners

  1. TRIM24 appears to promote liver tumor development via AMPK signaling

  2. in response to RA, TRIM24 serves as an adapter linking RARalpha to the proteasome for its degradation. In addition, TRIM24 and the proteasome are recruited with RARalpha to the promoters of target genes and thus are inherently linked to RARalpha transcriptional activity.

  3. findings establish a new link between histone H3 acetylation and SUMOylation of the reader protein TRIM24, a functional connection that may bear on TRIM24's oncogenic function and may inform future studies of PTM cross-talk between histones and epigenetic regulators

  4. TRIM24 and AR coactivated gene signature of SPOP-mutant prostate cancer (PCa) is similarly activated in human PCa with high TRIM28 expression.

  5. these results suggested that TRIM24 has an important role in the growth of Nasopharyngeal carcinoma (NPC). Additionally, silenced TRIM24 may lead to inhibited cell proliferation and induced cell apoptosis in NPC cells.

  6. TRIM24 is upregulated in HNSCC and promotes HNSCC cell growth and invasion through modulation of cell cycle, glucose metabolism, and GLUT3, making TRIM24 a potential oncoprotein in HNSCC.

  7. The findings identify TRIM24 as an oncogenic transcriptional co-activator in epidermal growth factor receptor-driven glioblastoma and also demonstrate a previously unknown signal relay by which H3K23ac/TRIM24 mediates epidermal growth factor receptor stimulation of STAT3 activation, thereby enhancing the oncogenic activity of the epidermal growth factor receptor/STAT3 pathway in human cancers.

  8. Results suggest that TRIM24 is a novel coactivator of the CAR that is involved in cell- and/or promoter- selective transactivation.

  9. TRIM24 expression was increased in human colorectal cancer and might be a novel prognostic biomarker.

  10. Study showed that TRIM24 was upregulated during gastric carcinogenesis and demonstrated that TRIM24 was a functional target gene of miR-511, and miR-511 inactivated PI3K/AKT and Wnt/beta-catenin pathways by suppressing TRIM24.

  11. Overexpression of KAT6A or TRIM24 promoted PIK3CA expression, AKT phosphorylation, and cell proliferation.

  12. we identified altered glucose metabolism in the progression of head and neck squamous cell carcinoma and showed that it could be partially attributed to the novel link between GLUT4 and TRIM24

  13. This study concluded that reduced TRIM24 protein is associated with poor survival in esophageal squamous cell cancer (ESCC) patients, suggesting TRIM24 protein is a potential prognostic biomarker for ESCC.

  14. Data suggest that, in cardiomyocytes, TRIM32 attenuates activation of SRF signaling and hypertrophy due to dysbindin; TRIM24 promotes these effects. TRIM32 promotes dysbindin degradation; TRIM24 protects dysbindin from degradation. (TRIM = tripartite motif-containing protein; SRF = serum response factor)

  15. hypothesis of "synergistic modification induced recognition" is then proposed to link histone modification and TRIM24 binding

  16. Report provides evidence for an oncogenic role for TRIM24 as a transcriptional activator and mediator of hormone-refractory prostate cancer cell growth in SPOP mutant and castration-resistant prostate cells.

  17. TRIM24 expression is positively correlated with Acetylated H3 lysine 23 levels, and high levels of both TRIM24 and Acetylated H3 lysine 23 predict shorter overall survival of breast cancer patients.

  18. TRIM24 regulate resistance to Gefitinib via Akt pathway in non-small cell lung cancer cells.

  19. TRIM24 is overexpressed in human bladder cancer and facilitates bladder cancer growth and invasion, possibly through NF-kappaB and AKT signaling pathways.

  20. functions as an oncogene in colorectal carcinogenesis

Mouse (Murine) Tripartite Motif Containing 24 (TRIM24) interaction partners

  1. Maintenance of pluripotency is regulated by a network of transcription factors coordinated by Oct4, Sox2, and Nanog; Trim24 significantly improved efficiency of cellular reprogramming, demonstrating its direct functionality in establishing pluripotency.

  2. data identify a previously unappreciated Trim24-dependent requirement for IL-1R expression on TH2 cells and an important nonredundant role for T-cell-intrinsic Trim24 in TH2-mediated allergy and antihelminth immunity

  3. Trim24 repressed VL30-class endogenous retroviruses retrotransposons

  4. These results identify Trim24 as a novel negative regulator of the IFN/STAT pathway and suggest that this repression through Rara inhibition may prevent liver cancer.

  5. Somatic hepatocyte-specific inactivation of TRIM24, TRIM28, or TRIM33 all promote hepatocellular carcinoma in a cell-autonomous manner in mice.

  6. TRIM24 regulates AR-mediated transcription in collaboration with TIP60 and BRD7.

  7. TIF1alpha-chromatin association is direct and involves DNA and nucleosome interactions mediated by the bromodomain

  8. These studies indicate that TIF1alpha is a factor that modulates the expression of a set of genes during the first wave of genome activation in the mouse embryo.

  9. The results not only provide genetic evidence that Trim24 and Rara co-regulate hepatocarcinogenesis in an antagonistic manner but also suggest that aberrant activation of Rara is deleterious to liver homeostasis.

  10. TIF1alpha-null mutant pathological phenotype supports the hypothesis that aging is promoted by increased activity of the vitamin D signaling pathway

TRIM24 Antigen Profile

Protein Summary

The protein encoded by this gene mediates transcriptional control by interaction with the activation function 2 (AF2) region of several nuclear receptors, including the estrogen, retinoic acid, and vitamin D3 receptors. The protein localizes to nuclear bodies and is thought to associate with chromatin and heterochromatin-associated factors. The protein is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains - a RING, a B-box type 1 and a B-box type 2 - and a coiled-coil region. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Gene names and symbols associated with TRIM24

  • tripartite motif containing 24 (TRIM24) antibody
  • tripartite motif containing 24 (trim24) antibody
  • transcription intermediary factor 1-alpha (LOC100548578) antibody
  • tripartite motif containing 24 S homeolog (trim24.S) antibody
  • tripartite motif-containing 24 (Trim24) antibody
  • A130082H20Rik antibody
  • AI447469 antibody
  • D430004I05Rik antibody
  • hTIF1 antibody
  • ptc6 antibody
  • rnf82 antibody
  • tf1a antibody
  • tif1 antibody
  • TIF1-alpha antibody
  • Tif1a antibody
  • TIF1alpha antibody
  • TRIM24 antibody

Protein level used designations for TRIM24

tripartite motif-containing 24 , transcriptional intermediary factor 1 alpha , tripartite motif containing 24 , E3 ubiquitin-protein ligase TRIM24 , RING finger protein 82 , TIF1-alpha , transcription intermediary factor 1-alpha , transcriptional intermediary factor 1 , E3 ubiquitin-protein ligase Trim24 , transcriptional intermediary factor 1, alpha , tripartite motif-containing protein 24 , Ab2-427

418106 Gallus gallus
463762 Pan troglodytes
537246 Bos taurus
710229 Macaca mulatta
100158542 Xenopus (Silurana) tropicalis
100348283 Oryctolagus cuniculus
100548578 Meleagris gallopavo
100558013 Anolis carolinensis
100597413 Nomascus leucogenys
8805 Homo sapiens
495130 Xenopus laevis
21848 Mus musculus
500084 Rattus norvegicus
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