TRIM24 antibody (C-Term)

Catalog No. ABIN6265731

Product Details anti-TRIM24 Antibody

Target: TRIM24 (Tripartite Motif Containing 24 (TRIM24))

Binding Specificity: C-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TRIM24 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificity: TRIM24 Antibody detects endogenous levels of total TRIM24.

Predicted Reactivity: Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human TRIM24, corresponding to a region within C-terminal amino acids.

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:3000, IHC: 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for TRIM24

Target: TRIM24 (Tripartite Motif Containing 24 (TRIM24))

Alternative Name: TRIM24 (TRIM24 Products)

Synonyms: TRIM24 antibody, PTC6 antibody, RNF82 antibody, TF1A antibody, TIF1 antibody, TIF1A antibody, TIF1ALPHA antibody, hTIF1 antibody, ptc6 antibody, rnf82 antibody, tf1a antibody, tif1 antibody, tif1a antibody, tif1alpha antibody, A130082H20Rik antibody, AI447469 antibody, D430004I05Rik antibody, TIF1-alpha antibody, TIF1alpha antibody, Tif1a antibody, tripartite motif containing 24 antibody, transcription intermediary factor 1-alpha antibody, tripartite motif containing 24 S homeolog antibody, tripartite motif-containing 24 antibody, TRIM24 antibody, trim24 antibody, LOC100548578 antibody, trim24.S antibody, Trim24 antibody

Background:

Description: Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. Promotes ubiquitination and proteasomal degradation of p53/TP53. Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes (By similarity).

Gene: TRIM24

Molecular Weight: 117kDa

Gene ID: 8805

UniProt: O15164