Tripartite Motif Containing 25 Proteins (TRIM25)

The protein encoded by TRIM25 is a member of the tripartite motif (TRIM) family. Additionally we are shipping TRIM25 Antibodies (157) and and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TRIM25 7706 Q14258
TRIM25 217069 Q61510
Rat TRIM25 TRIM25 494338  
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Top TRIM25 Proteins at antibodies-online.com

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$9,626.73
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$9,626.73
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Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 11 Days
$814.00
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TRIM25 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

More Proteins for Tripartite Motif Containing 25 (TRIM25) Interaction Partners

Human Tripartite Motif Containing 25 (TRIM25) interaction partners

  1. formation of unanchored K63-linked poly-ubiquitin chains is unchanged by NS1 binding, indicating that RING dimerisation of TRIM25 is not affected by NS1

  2. The RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain, which we postulate to be a novel RNA-binding domain.

  3. TRIM25 inhibits hepatocellular carcinoma progression by targeting MTA1.

  4. TRIM25 is a key determinant of breast cancer metastasis.

  5. V interaction with TRIM25 and RIG-I prevents TRIM25-mediated ubiquitination of RIG-I and disrupts downstream RIG-I signaling to the mitochondrial antiviral signaling protein.

  6. HPV E6 oncoprotein antagonizes the activation of the cytoplasmic innate immune sensor RIG-I by targeting its upstream regulatory enzymes TRIM25 and USP15. We further show that the RIG-I signaling cascade is important for an antiviral innate immune response to HPV16 infection

  7. this study shows thatTRIM25 targets ERG for degradation in prostate cancer

  8. TRIM25 actively participates in higher-order assembly of the RIG-I signalosome.

  9. Our results indicate that TRIM25 is associated with cisplatin resistance and 14-3-3sigma-MDM2-p53 signaling pathway is involved in this process, suggesting targeting TRIM25 may be a potential strategy for the reversal of cisplatin resistance.

  10. expression of TRIM25 might be critical for lung cancer cell migration, proliferation as well as doxorubicin resistance.

  11. Disturbed p53-MDM2 feedback loop contributing to the pathogenesis of thoracic aortic dissection may be linked to TRIM25 overexpression.

  12. the data uncover TRIM25 as a bona fide zinc-finger antiviral protein cofactor that leads to increased zinc-finger antiviral protein modification enhancing its translational inhibition activity.

  13. Studies showed that 70% of breast cancer patients were positive for Trim25 expression.

  14. we provide a detailed characterization of the TRIM ligases TRIM25 and TRIM32 and show how their oligomeric state is linked to catalytic activity

  15. The severe acute respiratory syndrome coronavirus N protein was found to bind to the SPRY domain of the tripartite motif protein 25 (TRIM25) E3 ubiquitin ligase, thereby interfering with the association between TRIM25 and retinoic acid-inducible gene I (RIG-I) and inhibiting TRIM25-mediated RIG-I ubiquitination and activation.

  16. TRIM25 is required for Zinc finger antiviral protein optimal binding to target mRNA.

  17. TRIM25 may exert its function through TGF-beta pathway.

  18. TRIM25 plays an additional role in RIG-I/MDA5 signaling other than RIG-I ubiquitination via activation of NF-kappaB.

  19. Data show that TRIM25 enhances p53 and Mdm2 abundance by preventing their proteasomal degradation. At the same time, TRIM25 inhibits p53's transcriptional activity and dampens the response to DNA damage.

  20. The PR-2B DENV-2 produced increased levels of subgenomic flavivirus RNA (sfRNA) relative to genomic RNA during replication. PR-2B sfRNA showed sequence dependent binding to and prevention of tripartite motif 25 (TRIM25) deubiquitylation, which is critical for sustained and amplified retinoic acid-inducible gene 1 (RIG-I)-induced type I interferon expression.

Mouse (Murine) Tripartite Motif Containing 25 (TRIM25) interaction partners

  1. TRIM25 as a key determinant of breast cancer metastasis.

  2. Studies indicated that mice with disrupted Trim25 were viable and fertile, uterine response to oestrogen was greatly attenuated and the uteri were underdeveloped.

  3. Two key residues (Asp(488) and Trp(621)) in the TRIM25 B30.2 domain are critical for binding to the RIG-I CARDs.

  4. Two well-known E3 ubiquitin ligases, Trim25 (also called Efp) and Trim71 (also called Lin41), are validated as RNA-binding proteins, revealing a potential link between RNA biology and protein-modification pathways.

TRIM25 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to the cytoplasm. The presence of potential DNA-binding and dimerization-transactivation domains suggests that this protein may act as a transcription factor, similar to several other members of the TRIM family. Expression of the gene is upregulated in response to estrogen, and it is thought to mediate estrogen actions in breast cancer as a primary response gene.

Gene names and symbols associated with TRIM25

  • E3 ubiquitin/ISG15 ligase TRIM25 (LOC100146440)
  • tripartite motif containing 25 (trim25)
  • E3 ubiquitin/ISG15 ligase TRIM25-like L homeolog (LOC100490741.L)
  • tripartite motif containing 25 (TRIM25)
  • microRNA 3614 (MIR3614)
  • tripartite motif-containing 25 (Trim25)
  • AA960166 protein
  • AL022677 protein
  • Efp protein
  • MGC130751 protein
  • RNF147 protein
  • Z147 protein
  • Zfp147 protein
  • zgc:55773 protein
  • Znf147 protein

Protein level used designations for TRIM25

tripartite motif-containing 25 , E3 ubiquitin/ISG15 ligase TRIM25 , tripartite motif containing 25 , RING finger protein 147 , estrogen-responsive finger protein , tripartite motif protein TRIM25 , tripartite motif-containing protein 25 , ubiquitin/ISG15-conjugating enzyme TRIM25 , zinc finger protein 147 (estrogen-responsive finger protein) , zinc finger protein-147 , tripartite motif protein 25 , zinc finger protein 147

GENE ID SPECIES
100146440 Equus caballus
393144 Danio rerio
431932 Xenopus laevis
455146 Pan troglodytes
100013883 Monodelphis domestica
100127751 Xenopus (Silurana) tropicalis
100440167 Pongo abelii
100599729 Nomascus leucogenys
7706 Homo sapiens
417401 Gallus gallus
510923 Bos taurus
491103 Canis lupus familiaris
217069 Mus musculus
494338 Rattus norvegicus
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