Tripartite Motif Containing 3 Proteins (TRIM3)

The protein encoded by TRIM3 is a member of the tripartite motif (TRIM) family, also called the 'RING-B-box-coiled-coil' (RBCC) subgroup of RING finger proteins. Additionally we are shipping Tripartite Motif Containing 3 Antibodies (81) and Tripartite Motif Containing 3 Kits (10) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TRIM3 10612 O75382
TRIM3 55992 Q9R1R2
TRIM3 83616 O70277
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Top Tripartite Motif Containing 3 Proteins at

Showing 5 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
Escherichia coli (E. coli) Human Un-conjugated SDS-PAGE analysis of Human TRIM3 Protein. 100 μg Log in to see 11 to 18 Days
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days

TRIM3 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

Rat (Rattus)

More Proteins for Tripartite Motif Containing 3 (TRIM3) Interaction Partners

Human Tripartite Motif Containing 3 (TRIM3) interaction partners

  1. TRIM3 plays a tumor-suppressing role in the regulation of liver cancer development by reducing cell proliferation through cell cycle arrest at the G0/G1 phase.

  2. The results of quantitative real-time RT-PCR and western blotting showed that the TRIM3 expression was very low in five cervical cancer cell lines. The TRIM3 overexpression weakened cell viability, and promote apoptosis of C-33A and SiHa cells in vitro, and inhibit tumor growth in vivo, which suggested that TRIM3 could reduce proliferation of cervical cancer cells.

  3. TRIM3 exerted an anti-proliferation role in rheumatoid arthritis fibroblast-like synoviocytes via p38 signaling pathway.

  4. results support a novel role for Brat/TRIM3 in maintaining stem cell equilibrium and suppressing tumor growth by regulating NICD nuclear transport

  5. TRIM3 functions as a tumour suppressor in CRC progression. This tumour-suppressive function is exerted partially through regulation of p53 protein.

  6. Studies indicate most-studied TRIpartite Motif (TRIM)-NHL proteins TRIM2, TRIM3, TRIM32 and TRIM71, and their mutations have been linked to diseases.

  7. TRIM3 may play a significant role in hepatocellular carcinoma progression.TRIM3 is downregulated in hepatocellular carcinoma at both the mRNA and protein levels and that low TRIM3 expression is correlated with an unfavorable prognosis.

  8. TRIM3 acts as a tumor suppressor in GBM by restoring asymmetric cell division.

  9. Data indicate TRIM3 and p21 interact in cells.

  10. TRIM63 is a candidate for genes mediating the glucocorticoid-induced promotion of osteoblastic differentiation.

  11. brain-expressed RING finger protein (BERP) is a gene whose expression is up-regulated in a p53-dependent manner

  12. the endosome-associated protein hrs is a subunit of a protein complex containing actinin-4, BERP, and myosin V that is necessary for efficient TfR recycling but not for EGFR degradation

  13. Loss of heterozygosity of chromosome segment 11p15.5 in malignant gliomas suggests TRIM3 as a candidate brain tumor suppressor gene.

  14. Using shotgun mass spectrometry, we found this protein differentially expressed in the dorsolateral prefrontal cortex from patients with schizophrenia.

Tripartite Motif Containing 3 (TRIM3) Protein Profile

Protein Summary

The protein encoded by this gene is a member of the tripartite motif (TRIM) family, also called the 'RING-B-box-coiled-coil' (RBCC) subgroup of RING finger proteins. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to cytoplasmic filaments. It is similar to a rat protein which is a specific partner for the tail domain of myosin V, a class of myosins which are involved in the targeted transport of organelles. The rat protein can also interact with alpha-actinin-4. Thus it is suggested that this human protein may play a role in myosin V-mediated cargo transport. Alternatively spliced transcript variants encoding the same isoform have been identified.

Gene names and symbols associated with TRIM3

  • tripartite motif containing 3 (TRIM3)
  • tripartite motif-containing 3 (Trim3)
  • tripartite motif containing 3 S homeolog (trim3.S)
  • tripartite motif containing 3 (Trim3)
  • tripartite motif containing 3b (trim3b)
  • Berp protein
  • BERP1 protein
  • HAC1 protein
  • Rnf22 protein
  • RNF97 protein
  • zgc:153967 protein

Protein level used designations for TRIM3

RING finger protein 97 , brain expressed ring finger , brain-expressed RING finger protein , ring finger protein 22 , tripartite motif protein TRIM3 , tripartite motif-containing 3 , tripartite motif-containing protein 3 , RING finger protein HAC1 , tripartite motif protein 3 , NHL repeat-containing protein 3

10612 Homo sapiens
55992 Mus musculus
83616 Rattus norvegicus
495223 Xenopus laevis
476834 Canis lupus familiaris
534510 Bos taurus
100739484 Sus scrofa
100734787 Cavia porcellus
555391 Danio rerio
100055164 Equus caballus
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