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The protein encoded by TRIM3 is a member of the tripartite motif (TRIM) family, also called the 'RING-B-box-coiled-coil' (RBCC) subgroup of RING finger proteins. Additionally we are shipping Tripartite Motif Containing 3 Antibodies (80) and Tripartite Motif Containing 3 Kits (10) and many more products for this protein.
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TRIM3 plays a tumor-suppressing role in the regulation of liver cancer development by reducing cell proliferation through cell cycle arrest at the G0/G1 phase.
The results of quantitative real-time RT-PCR and western blotting showed that the TRIM3 expression was very low in five cervical cancer cell lines. The TRIM3 overexpression weakened cell viability, and promote apoptosis of C-33A and SiHa cells in vitro, and inhibit tumor growth in vivo, which suggested that TRIM3 could reduce proliferation of cervical cancer cells.
TRIM3 exerted an anti-proliferation role in rheumatoid arthritis fibroblast-like synoviocytes via p38 (show CRK Proteins) signaling pathway.
results support a novel role for Brat/TRIM3 in maintaining stem cell equilibrium and suppressing tumor growth by regulating NICD (show NOTCH1 Proteins) nuclear transport
TRIM3 functions as a tumour suppressor in CRC (show CALR Proteins) progression. This tumour-suppressive function is exerted partially through regulation of p53 (show TP53 Proteins) protein.
Studies indicate most-studied TRIpartite Motif (TRIM (show TRAT1 Proteins))-NHL proteins TRIM2 (show TRIM2 Proteins), TRIM3, TRIM32 (show TRIM32 Proteins) and TRIM71 (show TRIM71 Proteins), and their mutations have been linked to diseases.
TRIM3 may play a significant role in hepatocellular carcinoma progression.TRIM3 is downregulated in hepatocellular carcinoma at both the mRNA and protein levels and that low TRIM3 expression is correlated with an unfavorable prognosis.
TRIM3 acts as a tumor suppressor in GBM by restoring asymmetric cell division.
Data indicate TRIM3 and p21 (show CDKN1A Proteins) interact in cells.
TRIM63 (show TRIM63 Proteins) is a candidate for genes mediating the glucocorticoid-induced promotion of osteoblastic differentiation.
Temporal control of gamma-actin (show ACTG1 Proteins) levels by TRIM3 is required to regulate the timing of hippocampal plasticity.
TRIM3, also known as BERP, interacts with KIF21B via its RBCC (show TRIM17 Proteins) domain.
the RING domain is required for TRIM3-induced growth suppression.
Data indicate TRIM3 and p21 interact in cells.
brain-expressed RING finger protein (BERP) is a gene whose expression is up-regulated in a p53 (show TP53 Proteins)-dependent manner
The protein encoded by this gene is a member of the tripartite motif (TRIM) family, also called the 'RING-B-box-coiled-coil' (RBCC) subgroup of RING finger proteins. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to cytoplasmic filaments. It is similar to a rat protein which is a specific partner for the tail domain of myosin V, a class of myosins which are involved in the targeted transport of organelles. The rat protein can also interact with alpha-actinin-4. Thus it is suggested that this human protein may play a role in myosin V-mediated cargo transport. Alternatively spliced transcript variants encoding the same isoform have been identified.
RING finger protein 97
, brain expressed ring finger
, brain-expressed RING finger protein
, ring finger protein 22
, tripartite motif protein TRIM3
, tripartite motif-containing 3
, tripartite motif-containing protein 3
, RING finger protein HAC1
, tripartite motif protein 3
, NHL repeat-containing protein 3