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TRIM38 encodes a member of the tripartite motif (TRIM) family. Additionally we are shipping TRIM38 Antibodies (103) and TRIM38 Kits (2) and many more products for this protein.
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Data suggest that mRNA/protein levels of NLRP6 are down-regulated in synovial tissues and synoviocytes of rheumatoid arthritis (RA) patients compared to osteoarthritis patients; NLRP6 provides docking site to facilitate interaction between TAB2 (show TAB2 Proteins)/3 and TRIM38 in RA synoviocytes in response to TNFalpha (show TNF Proteins). (NLRP6 = ; TAB2 (show TAB2 Proteins)/3 = transforming growth factor-b (show ATP5S Proteins)-activated kinase 1-binding protein 2/3; TRIM38 = tripartite motif 38)
TRIM38 may act as a novel negative regulator for TLR3 (show TLR3 Proteins)-mediated type I interferon (show IFNA Proteins) signaling by targeting TRIF (show TRIM69 Proteins) for degradation
NF-kappaB (show NFKB1 Proteins) is activated in response to TRIM38.
Enterovirus 71 infection induces degradation of TRIM38.
Data show that tripartite motif-containing 38 protein (Trim38) deficiency potentiates toll (show TLR4 Proteins) like receptors TLR3 (show TLR3 Proteins)/4-mediated signaling in primary immune cells.
TRIM38 is a negative regulator for Toll like receptor (TLR) and retinoic acid-inducible gene (RIG)-I-mediated IFN-beta production by targeting Nck-associated protein NAP1 for ubiquitination and subsequent proteasome-mediated degradation.
ur findings defined a novel function for TRIM38 to prevent excessive TLR-induced inflammatory responses through proteasomal degradation of TRAF6 (show TRAF6 Proteins).
This gene encodes a member of the tripartite motif (TRIM) family. The encoded protein contains a RING-type zinc finger, B box-type zinc finger and SPRY domain. The function of this protein has not been identified. A pseudogene of this gene is located on the long arm of chromosome 4.
tripartite motif-containing 38
, tripartite motif-containing protein 38-like
, tripartite motif containing 38
, Ro/SSA ribonucleoprotein homolog
, ring finger protein 15
, tripartite motif-containing protein 38
, zinc finger protein RoRet
, RING finger protein 15