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The protein encoded by TRIM55 contains a RING zinc finger, a motif known to be involved in protein-protein interactions. Additionally we are shipping TRIM55 Antibodies (28) and many more products for this protein.
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The study suggested that the porcine MuRF2 and MuRF3 genes are involved in the muscle growth and development.
MuRF2 regulates PPARgamma1 activity to protect against diabetic cardiomyopathy and enhance weight gain induced by a high fat diet.
MuRF1 and MuRF2 play a redundant role in regulating developmental physiologic hypertrophy, by regulating E2F transcription factors essential for normal cardiac development and by supporting E2F localization to the nucleus, but not through degradation.
results indicate that MURF2A and MURF2B proteins could participate in the molecular switch between the two ubiquitin degradative pathways.
MURF2 isoforms undergo pre- and postnatal switching and overall downregulation in developing skeletal muscle.
MURF2 expression parallels that of the autophagy-associated proteins LC3, p62/SQSTM1 and nbr1
Data suggest that expression of MuRF1 is required for remodeling of type-II fibers under pathophysiological stress states, whereas MuRF1 and MuRF2 together are required for maintenance of type-II fibers, possibly via the regulation of myozenin-1.
Double knockout (dKO) mice obtained by the inactivation of all four MuRF1 and MuRF2 alleles developed extreme cardiac and milder skeletal muscle hypertrophy.
The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This protein associates transiently with microtubules, myosin, and titin during muscle sarcomere assembly. It may act as a transient adaptor and plays a regulatory role in the assembly of sarcomeres. Four alternatively spliced transcript variants encoding distinct isoforms have been described.
muscle specific ring finger 2
, muscle-specific RING finger protein 2
, ring finger protein 29
, tripartite motif-containing 55
, tripartite motif-containing protein 55
, tripartite motif-containing protein 55-like
, uncharacterized protein LOC100036929